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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

null

《医学前沿（英文）》 2016年第10卷第1期页码 41-51 doi: 10.1007/s11684-016-0429-z

摘要：

Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue (P<0.001). Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage (P<0.001). High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging (all P<0.05). Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort (93.73 vs. 172.1 months; P<0.001, log-rank test) and in subgroups with stages Tis+ I+ II and III+ IV. Furthermore, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P<0.05). This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.

关键词： breast cancer MID2 proliferation overall survival xenograft

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Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

《医学前沿（英文）》 2016年第10卷第2期页码 137-142 doi: 10.1007/s11684-016-0449-8

摘要：

Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided into syndromic hearing loss (associated with other anomalies) and non-syndromic hearing loss (not associated with other anomalies). Approximately 80% of genetic deafness is non-syndromic. On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided into high-, mid-, low-, and total-frequency hearing loss. An audiometric finding of mid-frequency sensorineural hearing loss, or a “bowl-shaped” audiogram, is uncommon. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness genes.

关键词： hereditary non-syndromic hearing loss mid-frequency hearing loss deafness genes

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Experimental study on seismic behavior of mid-rise RC shear wall with concealed truss

Wanlin CAO, Jianwei ZHANG, Jingna ZHANG, Min WANG,

《结构与土木工程前沿（英文）》 2009年第3卷第4期页码 370-377 doi: 10.1007/s11709-009-0062-x

摘要： In this paper, mid-rise shear wall with concealed truss was proposed. This new composite shear wall includes two kinds of composition: one is the composition of two bearing systems, including truss and shear wall, and the other is the composition of two materials, including steel and concrete. Therefore, it is a double composite shear wall. The experimental study on the seismic behavior of six 1/3 scale mid-rise shear walls, including an ordinary mid-rise shear wall, a mid-rise shear wall with steel frame, and four mid-rise shear wall with concealed truss made of different materials, was studied. Based on the experimental study, the stiffness and its attenuation, bearing capacity, ductility, hysteretic property, energy dissipation, and failure phenomena of each shear wall were contrastively analyzed. The formulas of bearing capacity and stiffness were established. The results obtained from the formulas and those from experiment are in good agreement. Some suggestions for seismic design of shear wall are given in this paper. The experimental results show that the seismic behavior of the mid-rise shear wall with steel frame and that of every truss with different materials is obviously improved.

关键词： reinforced concrete profile steel concealed truss mid-rise shear wall seismic behavior

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Synthesis of mid-dicarboxy polystyrene by ATRP and formation of ionic-bonded supramolecules

YU Tao, WANG Yun, LU Dairen, BAI Ruke, LU Weiqi

《化学科学与工程前沿（英文）》 2007年第1卷第2期页码 140-145 doi: 10.1007/s11705-007-0026-4

摘要： Dimethyl 4, 6-bis (bromomethyl) isophthalate was synthesized by bromomethylation, oxidation, esterification and bromination of 1, 3-dimethylbenzene. This was used to initiate the atom transfer radical polymerization of styrene successfully. Results showed that the process had some of the good characteristics of controlled/living free radical polymerization. The molecular weight of the obtained polymer increased linearly with monomer conversion, its molecular weight distribution was very narrow, and a linear relationship between ln([]/[]) and polymerization time was found. A well-defined novel structural polystyrene containing two ester groups in the mid-main chain was prepared with controlled molecular weight and narrow polydispersity. The structure of the polymer was confirmed by H-NMR spectra. After being hydrolyzed, dicarboxy polystyrene was obtained and used to form ionic-bonded supramolecules with 1-dodecanamine as a model of the star-shaped supramolecules. The supramolecules formed were characterized by Fourier transform infrared (FTIR) spectrum.

关键词： controlled molecular conversion bromination relationship isophthalate

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A survey of decorative materials on the energy consumption of mid-rise residential buildings in Mashad

Masoud Taheri SHAHRAEIN, Lihua ZHAO, Qinglin MENG

《结构与土木工程前沿（英文）》 2010年第4卷第4期页码 490-497 doi: 10.1007/s11709-010-0068-4

摘要： Polyvinylchloride (PVC) panel is one of the most favorite decorative materials that has been popularly applied as finishing of ceiling in residential buildings. It is about five years that the people incline to redecorate the ceiling of old buildings with PVC panel in big cities of Iran, such as Mashad. In this study, the influence of ceiling PVC panel on the cooling and heating loads of studied apartment were determined by software DeST-h. In addition, the summer natural ventilation of the mentioned apartment is investigated by determining the wind speed into the apartment through the computational fluid dynamics (CFD) software. The evaluation of environment indoor wind velocity showed that most of the apartment space is a comfortable zone. The results of studied building analyses demonstrated that using PVC panel on the ceiling can decline the energy consumption of the penthouse (fifth level) of the investigated building, which is about 3.7% and 7% for studied methods of without and with air layer, respectively. In addition, although the existence of air layer can decline the cooling and heating loads, the increase in air layer thickness did not show significant decrease on building energy consumption. However, the PVC panel is expensive and is not suitable to be used for ceiling thermal insulation, but adding a thin layer of air between ceiling and PVC panel can be a good step toward sustainable building, when the people are inclined to utilize it as a decorative ceiling.

关键词： residential apartments natural ventilation energy consumption decorative materials Mashad

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我国中长期发电供应能力研究

白建华, 辛颂旭

《中国工程科学》 2011年第13卷第6期页码 65-74

摘要：

结合我国能源资源储量、禀赋特点和能源发展相关政策，对我国中长期发电供应能力进行了全面的分析，包括燃煤发电、水电、核能发电、风力发电、太阳能发电、生物质能发电和天然气发电的供应能力。在此基础上，以社会总体成本最小为原则，对我国中长期电源结构调整进行了研究，同时研判了我国中长期电源发展布局。

关键词：发电供应能力中长期电源结构电源布局

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智能预报模式与水文中长期智能预报方法

陈守煜,郭瑜,王大刚

《中国工程科学》 2006年第8卷第7期页码 30-35

摘要：

建立了以模糊优选、BP神经网络及遗传算法有机结合的智能预报模式与方法。在应用该方法进行中长期水文智能预报时，首先选取训练样本的数量，根据预报因子与预报对象的相关关系得到相对隶属度矩阵;再将其作为BP神经网络输入值以训练连接权重；最后将得到的连接权重值用于预报检验。计算结果表明，智能预报模式与方法的运行速度、精度及稳定性都达到了实际应用的要求。

关键词：模糊优选 BP神经网络遗传算法智能预报模式中长期水文智能预报

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我国电力中长期发展战略研究

杨奇逊,蒋宜国,丛琳,姚愉芳,白建华

《中国工程科学》 2011年第13卷第6期页码 57-64

摘要：

在预测中长期我国用电量需求的基础上，通过分析燃煤发电、水电、核电、非水可再生能源发电、天然气发电的供应能力，阐明了中长期我国电源发展的原则和目标，提出了中长期我国电网发展模式，并指出要以智能配用电、智能调度、大规模储能、超导电力、分布式供电等新型电力技术为支撑实现我国中长期电力发展战略。

关键词：能源发展战略电力发展战略中长期

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我国可再生能源中长期（2030、2050）发展战略目标与途径

黄其励,高虎,赵勇强

《中国工程科学》 2011年第13卷第6期页码 88-94

摘要：

基于我国调整能源结构的战略方针和以煤为主要一次能源的国情，根据可再生能源在技术、产业等方面的发展形势，从可持续发展的战略高度和大能源体系的视野，分析了2030年、2050年我国可再生能源发展的战略目标、技术路线、发展重点和保障政策，指出通过重点发展可再生能源发电、大力发展可再生能源热利用和燃气技术、积极努力发展生物质交通燃料技术，使可再生能源从目前的补充能源，逐步提升到2020年的替代能源、2030年的主流能源和2050年的主导能源的战略地位。

关键词：可再生能源中长期战略目标途径

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Seismic fragility assessment of revised MRT buildings considering typical construction changes

Rakesh DUMARU, Hugo RODRIGUES, Humberto VARUM

《结构与土木工程前沿（英文）》 2020年第14卷第1期页码 241-266 doi: 10.1007/s11709-019-0560-4

摘要： The present study investigates the vulnerability assessment of the prototype revised Mandatory Rule of Thumb (MRT) buildings initially designed and detailed for three storeys bare frame building; later modified through variable number of storeys (three, four, and five) and different arrangement of infill walls (bare frame, soft-storey, irregular infilled, and fully infilled). The application of infill walls increases the fundamental frequencies, stiffness, and maximum strength capacity, but reduces the deformation capability than the bare frame building. The vulnerability was also reduced through infill walls, where the probability of exceeding partial-collapse and collapse damage reduced by 80% and 50%, respectively. Furthermore, the increased in storeys (three to five) also increases the failure probability, such that partial-collapse and collapse for fully infilled increases by almost 55% and 80%, respectively. All obtained results and discussions concluded that the structural sections and details assigned for MRT building is not sufficient if considered as bare frame and soft-storey. And increase in number of storeys causes building highly vulnerable although the infill walls were considered.

关键词： mid-rise buildings revised NBC 205: 2012 masonry infill walls configurations of infill walls vulnerability assessment and inter-storey drift

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复杂机械结构中高频动响应能量有限元方法研究

祝丹晖,解妙霞,孔祥杰,张文博,陈花玲

《中国工程科学》 2013年第15卷第1期页码 106-112

摘要：

从理论研究和应用研究两个方面追踪了国内外关于能量有限元的发展现状，并指出能量有限元已趋向于预示越来越复杂的结构动响应；接下来介绍本课题组近年来利用能量有限元方法针对实际复杂结构及复杂载荷环境中的高频动响应问题所做的研究工作，主要包括3个部分：一是在考虑多种传递波功率流耦合的情况下，发展了圆柱壳、截锥壳等复杂结构的高频响应能量有限元方法，从而得到了此类结构的中高频局部动响应特性；二是考虑在脉动载荷、混响室等复杂环境中，利用能量有限元方法并结合能量边界元方法预示了结构的高频振动特性和声振耦合特性；三是开发了能量有限元的计算软件，为其大规模应用奠定了基础。最后指出了能量有限元方法目前存在的问题和进一步研究的方向。

关键词：中高频响应能量有限元方法声振响应预示机械结构动力学

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水电中长期（2030、2050）发展战略研究

晏志勇,钱钢粮

《中国工程科学》 2011年第13卷第6期页码 108-112

摘要：

以我国水力资源蕴藏量及分布特点为基础，分析我国水力资源的地位和作用，回顾水力资源开发的历程与现状，对比分析我国与国外部分国家水电开发的差异，提出我国水电开发的战略思路、目标及重点，并提出未来水电开发有关措施和建议。

关键词：水力资源水电发展目标重点保障措施

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第三届环境、工业和能源工程国际会议(EI2E 2019)

会议日期： 2019年09月19日

会议地点：宁夏银川

主办单位： APISE

石油替代战略与生物质能源中长期发展目标

李十中

《中国工程科学》 2011年第13卷第6期页码 101-107

摘要：

以我国发展生物质能源的资源保障为基础，包括土地资源、林地资源、秸秆资源、农林剩余物，以及有机废弃物资源等，分析了我国生物质资源的地位作用和发展前景，综述了燃料乙醇、生物柴油、沼气等主要生物能源产品及其转化技术，介绍了我国对各种生物质能源产品从目前到2050年分阶段的发展目标，并且从政策、技术、环保等多个角度，提出了一些发展生物质能源的建议。

关键词：生物质能源资源保障生物质产品发展目标

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中国的科学、绿色、低碳能源战略

杜祥琬,周大地

《中国工程科学》 2011年第13卷第6期页码 4-10

摘要：

首先分析了国际能源发展的战略态势和我国能源的形势、存在的主要问题和面临的挑战。接着提出我国能源中长期发展战略的指导思想和原则，强调中国特色的新型能源战略必须体现科学发展观，以科学的供给保障合理的需求。给出了21世纪上半叶我国能源发展阶段的战略定位，阐述了我国“科学、绿色、低碳能源战略”的基本内涵，包括它的6个子战略：a.强化“节能优先，总量控制”战略，提出了煤炭石油消耗“天花板”的概念；b.煤炭的科学开采、洁净高效利用和战略地位的调整，提出了“煤炭科学产能”的概念和“洁净化度”的概念；c.确保油气的战略支柱地位，把天然气作为能源结构调整的重点之一；d.积极发展水电和非水可再生能源，使之成为我国的绿色能源支柱之一；e.积极发展核电是我国能源可持续发展的重大战略选择；f.发展中国特色的适应电源多元化的高效安全智能电力系统，发展非上网等用电方式和储能技术。“科学、绿色、低碳能源战略”是经济与环境双赢的战略，也是应对气候变化国家战略的重要组成部分。“科学、绿色、低碳能源战略”的实施需要强有力的科技支撑，提出了科技支撑的3个层次，给出了21世纪上半叶我国能源发展的展望，最后提出了为实施“科学、绿色、低碳能源战略”的若干重大建议。

关键词：中国能源中长期发展战略绿色低碳