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SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2
Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 81-92 doi: 10.15302/J-FASE-2017180
Sall4 as one of the spalt family members contains several alternative splicing variants, which are differentially expressed and has a key role in maintaining pluripotent stem cells. However, the molecular features and function of SALL4 have not been well elucidated in porcine induced pluripotent stem cells (piPSCs). In this study, we identified splice variants and found two splicing variants through analysis of the porcine transcriptome data derived from piPSCs. SALL4A was only detected in piPSCs but SALL4B was globally expressed in porcine tissues and piPSCs. The level of SALL4B was significantly reduced when piPSCs differentiation occurred, however, the expression of SALL4A was not affected, indicating that SALL4B may be essential for the maintenance of piPSCs self-renewal. Overexpression of SALL4A and SALL4B in PEF cells could significantly stimulated expression of endogenous pluripotent genes, when SALL4B significantly promoted OCT4 expression. Conversely, SALL4A significantly promoted KLF4 expression. Additionally, both SALL4A and SALL4B could repress promoter activity in a dose-dependent manner. Conversely, OTX2 also negatively regulated SALL4 expression. These observations indicate that a negative feedback regulatory mechanism may exist between SALL4 and OTX2, which is useful for the maintenance of the self-renewal of piPSCs.
ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic
《化学科学与工程前沿(英文)》 2023年 第17卷 第11期 页码 1728-1740 doi: 10.1007/s11705-023-2322-z
关键词: ZnFe2O4/BiVO4 Z-scheme heterojunction photocatalytic degradation ciprofloxacin
Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance
Shifeng YANG, Wenfeng REN, Jian CHEN
《能源前沿(英文)》 2017年 第11卷 第3期 页码 374-382 doi: 10.1007/s11708-017-0494-2
关键词: lithium-ion batteries cathode material LiNi0.5Mn1.5O4 lithium-ion conductor coating
Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan
《环境科学与工程前沿(英文)》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1224-2
关键词: 2 2′ 4 4′-tetrabromodiphenyl ether (BDE-47) Ascorbic acid Reductive debromination Zero-valent zinc
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and
《医学前沿(英文)》 2023年 第17卷 第1期 页码 132-142 doi: 10.1007/s11684-022-0938-x
4D打印定律 Article
Farhang Momeni, Jun Ni
《工程(英文)》 2020年 第6卷 第9期 页码 1035-1055 doi: 10.1016/j.eng.2020.01.015
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1090-1100 doi: 10.1007/s11705-021-2091-5
关键词: synthesis pyrimidin-4-amine derivatives 1 2 4-oxadiazole insecticidal activity structure-activity relationship
Veronika BOLSHAKOVA, Annie GUERRIERO, Gilles HALIN
《工程管理前沿(英文)》 2020年 第7卷 第1期 页码 104-118 doi: 10.1007/s42524-019-0041-4
关键词: BIM 4D BIM 4D BIM use AEC project management collaboration decision making
4Pi荧光超分辨显微术综述 Review
郝翔, 李依明, 傅爽, 李旸晖, 许迎科, 匡翠方, 刘旭
《工程(英文)》 2022年 第11卷 第4期 页码 146-153 doi: 10.1016/j.eng.2020.07.028
对双层组件4D打印可逆性的初步研究 Article
Amelia Yilin Lee, Jia An, Chee Kai Chu, Yi Zhang
《工程(英文)》 2019年 第5卷 第6期 页码 1159-1170 doi: 10.1016/j.eng.2019.09.007
增材制造的快速发展和形状记忆聚合物材料的进步推动了四维(4D)打印技术的进展。随着设计方面的不断改进,逐渐证明有可能实现可逆4D打印或双向4D打印。这项技术将完全消除对人为干预的需要,因为编程完全由外部刺激驱动,这使得4D打印部件可以在多个周期内启动。本研究提出了一种新的可逆4D打印驱动方法,其中弹性体的溶胀和热量用于编程阶段,以及热量用于恢复阶段。本研究的主要重点在于自驱动设计这一步骤。采用这种方式理解曲率可以提供对可逆4D打印结构的高度控制。
Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine
CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping
《化学科学与工程前沿(英文)》 2008年 第2卷 第2期 页码 220-223 doi: 10.1007/s11705-008-0041-0
关键词: L-4-Fluorophenylalanine Asp-AT aspartate aminotransferase 4-fluorophenylpyruvate FPPA
BRD4 interacts with PML/RARα in acute promyelocytic leukemia
Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang
《医学前沿(英文)》 2018年 第12卷 第6期 页码 726-734 doi: 10.1007/s11684-017-0604-x
关键词: BRD4 PML/RARα APL interaction
ECRG4: a new potential target in precision medicine
Xin Qin, Ping Zhang
《医学前沿(英文)》 2019年 第13卷 第5期 页码 540-546 doi: 10.1007/s11684-018-0637-9
关键词: ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis
李成名
《中国工程科学》 2013年 第15卷 第5期 页码 37-41
标题 作者 时间 类型 操作
SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2
Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG
期刊论文
Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic
Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan
期刊论文
Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4
期刊论文
Identifying stakeholders’ roles and relevant project documents for 4D-based collaborative decision making
Veronika BOLSHAKOVA, Annie GUERRIERO, Gilles HALIN
期刊论文
Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine
CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping
期刊论文
BRD4 interacts with PML/RARα in acute promyelocytic leukemia
Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang
期刊论文