检索范围:
排序: 展示方式:
Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels
Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA
《农业科学与工程前沿(英文)》 2019年 第6卷 第2期 页码 197-205 doi: 10.15302/J-FASE-2018245
The present study was designed to investigate the protective effects of leonurine, a compound purified from that is active on ischemic rat behavior and cortical neurons, and explore the underlying mechanism. The general rat activity, cortical neuron morphology, superoxide dismutase (SOD), malondialdehyde (MDA), -aminobutyric acid (GABA) and glutamate decarboxylase 67 (GAD67) levels were measured. We found leonurine significantly improve the general activity of rats in an open-field test, which was associated with attenuated neuronal damage induced by ischemia. Moreover, serum SOD activity was significantly greater, MDA level lower in the leonurine group as compared with ischemia group. In addition, GABA content in the cerebral cortex was significantly greater in high-dose leonurine group. Correspondingly, GAD67 protein level coincided with the GABA level. Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative and anti-excitotoxicity effects by targeting GABA and leonurine might become a useful adjuvant neuroprotective agent.
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 645-658 doi: 10.15302/J-FASE -2020350
Superoxide dismutase (SOD) is an important enzyme in the antioxidant system of plants and plays a vital role in stress responses by maintaining the dynamic balance of reactive oxygen species (ROS) concentrations. Genome-wide analysis of the SOD gene family in various plant species has been conducted but little is known about this gene family in watermelon (Citrullus lanatus). Here, eight SOD genes were identified in the watermelon genome and are designated ClCSD1-5, ClFSD1-2 and ClMSD according to their metal cofactors. Phylogenetic analysis shows that SOD proteins from various plant species can be classified into five groups and members in the same group possess the same metal cofactor and similar subcellular localizations. Expression analysis of the ClSOD genes indicates that they had tissue-specific expression patterns with high expression in different tissues including the leaves, flowers and fruit. In addition, the expression of ClSOD genes differed appreciably under salinity, drought and abscisic acid (ABA) treatments, indicating that they may be involved in ROS scavenging under different abiotic stresses via an ABA-dependent signaling pathway. These results lay the foundation for elucidating the function of ClSOD genes in stress tolerance and fruit development in watermelon.
关键词: abiotic stress / expression analysis / phylogeny / SOD / superoxide dismutase / watermelon
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
Yong ZHOU, Linjuan OUYANG, Dahu ZHOU, Yicong CAI, Haohua HE
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 645-658 doi: 10.15302/J-FASE-2020350
关键词: abiotic stress expression analysis phylogeny SOD superoxide dismutase watermelon
标题 作者 时间 类型 操作
Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels
Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA
期刊论文
SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES
期刊论文