检索范围:
排序: 展示方式:
Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU
《农业科学与工程前沿(英文)》 2014年 第1卷 第4期 页码 314-320 doi: 10.15302/J-FASE-2014038
关键词: TLR4 transgenic ewe safety assessment reproductive trait oocyte DNA methylation
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
《医学前沿(英文)》 2021年 第15卷 第2期 页码 292-301 doi: 10.1007/s11684-020-0806-5
关键词: bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 288-303 doi: 10.1007/s11684-015-0412-0
Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self-renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.
关键词: TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic
《化学科学与工程前沿(英文)》 2023年 第17卷 第11期 页码 1728-1740 doi: 10.1007/s11705-023-2322-z
关键词: ZnFe2O4/BiVO4 Z-scheme heterojunction photocatalytic degradation ciprofloxacin
Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance
Shifeng YANG, Wenfeng REN, Jian CHEN
《能源前沿(英文)》 2017年 第11卷 第3期 页码 374-382 doi: 10.1007/s11708-017-0494-2
关键词: lithium-ion batteries cathode material LiNi0.5Mn1.5O4 lithium-ion conductor coating
Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan
《环境科学与工程前沿(英文)》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1224-2
关键词: 2 2′ 4 4′-tetrabromodiphenyl ether (BDE-47) Ascorbic acid Reductive debromination Zero-valent zinc
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and
《医学前沿(英文)》 2023年 第17卷 第1期 页码 132-142 doi: 10.1007/s11684-022-0938-x
4D打印定律 Article
Farhang Momeni, Jun Ni
《工程(英文)》 2020年 第6卷 第9期 页码 1035-1055 doi: 10.1016/j.eng.2020.01.015
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1090-1100 doi: 10.1007/s11705-021-2091-5
关键词: synthesis pyrimidin-4-amine derivatives 1 2 4-oxadiazole insecticidal activity structure-activity relationship
Veronika BOLSHAKOVA, Annie GUERRIERO, Gilles HALIN
《工程管理前沿(英文)》 2020年 第7卷 第1期 页码 104-118 doi: 10.1007/s42524-019-0041-4
关键词: BIM 4D BIM 4D BIM use AEC project management collaboration decision making
4Pi荧光超分辨显微术综述 Review
郝翔, 李依明, 傅爽, 李旸晖, 许迎科, 匡翠方, 刘旭
《工程(英文)》 2022年 第11卷 第4期 页码 146-153 doi: 10.1016/j.eng.2020.07.028
对双层组件4D打印可逆性的初步研究 Article
Amelia Yilin Lee, Jia An, Chee Kai Chu, Yi Zhang
《工程(英文)》 2019年 第5卷 第6期 页码 1159-1170 doi: 10.1016/j.eng.2019.09.007
增材制造的快速发展和形状记忆聚合物材料的进步推动了四维(4D)打印技术的进展。随着设计方面的不断改进,逐渐证明有可能实现可逆4D打印或双向4D打印。这项技术将完全消除对人为干预的需要,因为编程完全由外部刺激驱动,这使得4D打印部件可以在多个周期内启动。本研究提出了一种新的可逆4D打印驱动方法,其中弹性体的溶胀和热量用于编程阶段,以及热量用于恢复阶段。本研究的主要重点在于自驱动设计这一步骤。采用这种方式理解曲率可以提供对可逆4D打印结构的高度控制。
Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine
CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping
《化学科学与工程前沿(英文)》 2008年 第2卷 第2期 页码 220-223 doi: 10.1007/s11705-008-0041-0
关键词: L-4-Fluorophenylalanine Asp-AT aspartate aminotransferase 4-fluorophenylpyruvate FPPA
BRD4 interacts with PML/RARα in acute promyelocytic leukemia
Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang
《医学前沿(英文)》 2018年 第12卷 第6期 页码 726-734 doi: 10.1007/s11684-017-0604-x
关键词: BRD4 PML/RARα APL interaction
ECRG4: a new potential target in precision medicine
Xin Qin, Ping Zhang
《医学前沿(英文)》 2019年 第13卷 第5期 页码 540-546 doi: 10.1007/s11684-018-0637-9
关键词: ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis
标题 作者 时间 类型 操作
Effects of the
Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU
期刊论文
acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like receptor 4
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
期刊论文
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
null
期刊论文
Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic
Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan
期刊论文
Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4
期刊论文
Identifying stakeholders’ roles and relevant project documents for 4D-based collaborative decision making
Veronika BOLSHAKOVA, Annie GUERRIERO, Gilles HALIN
期刊论文
Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine
CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping
期刊论文
BRD4 interacts with PML/RARα in acute promyelocytic leukemia
Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang
期刊论文