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抗生素 2

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食品安全；环境新污染物；抗生素；全氟化合物；内分泌干扰物；微塑料 1

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Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by

WEI Yimei,ZHANG Yuan,XU Jian,GUO Changsheng,LI Lei,FAN Wenhong

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 357-371 doi: 10.1007/s11783-013-0580-6

摘要： Precise and sensitive methods for the simultaneous determination of different classes of antibiotics, including sulphonamides, fluoroquinolones, macrolides, tetracyclines, and trimethoprim in surface water, sediments, and fish muscles were developed. In water samples, drugs were extracted with solid-phase extraction (SPE) by passing 1000 mL of water through hydrophilic lipophilic balanced (HLB) SPE cartridges. Sediment samples were solvent-extracted, followed by tandem SPE (strong anion exchange (SAX) + HLB) clean-ups. Fish muscles were extracted by a mixture of acetonitrile and citric buffer (80:20, v/v) solution, and cleaned by SPE. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) with multiple reaction monitoring (MRM) detection was employed to quantify all compounds. The recoveries for the antibiotics in the spiked water, sediment, and fish samples were 60.2%–95.8%, 48.1%–105.3%, and 59.8%–103.4%, respectively. The methods were applied to samples taken from Dianchi Lake, China. It showed that concentrations of the detected antibiotics ranged from limits of quantification (LOQ) to 713.6 ng·L (ofloxacin) in surface water and from less than LOQ to 344.8 μg·kg (sulphamethoxazole) in sediments. The number of detected antibiotics and the overall antibiotic concentrations were higher in the urban area than the rural area, indicating the probable role of livestock and human activities as important sources of antibiotic contamination. In fish muscles, the concentration of norfloxacin was the highest (up to 38.5 μg·kg ), but tetracyclines and macrolides were relatively low. Results showed that the methods were rapid and sensitive, and capable of determining several classes of antibiotics from each of the water, sediment, and fish matrices in a single run.

关键词： antibiotics     liquid chromatography–tandem mass spectrometry (LC-MS/MS)     water     sediment     fish muscle    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

《医学前沿（英文）》 2022年 第16卷 第3期   页码 307-321 doi: 10.1007/s11684-022-0927-0

摘要： The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an important role in the development of cancer immunotherapy. However, immune-related adverse events often occur because of the enhanced immune response enabled by these agents. Antibiotics are widely applied in clinical treatment, and they are inevitably used in combination with immune checkpoint inhibitors. Clinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitors. Studies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitors and antibiotics, although the exact mechanisms remain unclear. This review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an in-depth discussion about the mechanisms and therapeutic potential of modulating gut microbiota, as well as other new combination strategies.

关键词： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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Decoding and quantitative detection of antibiotics by a luminescent mixed-lanthanide-organic framework

《环境科学与工程前沿（英文）》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1589-5

摘要：

● A series of mixed-LOFs and portable LOF-fibers were synthesized.

关键词： Antibiotics     Sensor     Luminescence     Lanthanide-organic frameworks    

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cellulose and κ-carrageenan composite aerogel with efficient performance in removal of fluoroquinolone antibiotics

《环境科学与工程前沿（英文）》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1568-x

摘要：

● A composite aerogel was simply obtained to remove various fluoroquinolones (FQs).

关键词： Composite aerogel of carboxymethyl cellulose and κ-carrageenan     Fluoroquinolone antibiotics     Adsorption performance     Coexisting substances     Adsorption mechanism     Reusability    

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Occurrence and fate of typical antibiotics in wastewater treatment plants in Harbin, North-east China

Weihua Wang, Wanfeng Zhang, Hong Liang, Dawen Gao

《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1118-3

摘要：

• The concentration distributions and removals of 12 antibiotics were investigated.

• Macrolides and fluoroquinolones presented relatively higher concentrations.

• The removal of antibiotics did not differ among the different treatment processes.

关键词： Antibiotics     WWTPs     Occurrence     Removal efficiency    

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Occurrence and fate of antibiotics in advanced wastewater treatment facilities and receiving rivers in

Xinwei LI,Hanchang SHI,Kuixiao LI,Liang ZHANG,Yiping GAN

《环境科学与工程前沿（英文）》 2014年 第8卷 第6期   页码 888-894 doi: 10.1007/s11783-014-0735-0

摘要： The occurrence and removal of 13 antibiotics were investigated in five wastewater treatment plants (WWTPs) with advanced wastewater treatment processes in Beijing, China. Most of the target antibiotics were detected in the secondary and tertiary effluents, with the concentrations of 4.8–1106.0 and 0.3–505.0 ng·L . Fluoroquinolone antibiotics showed relatively high concentrations in all samples (782–1814 ng·L ). Different tertiary treatment processes showed discrepant antibiotics removal performances. Ozonation process was found more effective in removing target antibiotics compared to the coagulation-flocculation-sedimentation process and sand filtration process. Investigation of the target antibiotics in three typical urban rivers in Beijing was carried out to understand antibiotics occurrence in surface water environment. Eight antibiotics were detected in the studied rivers, with highest concentration of antibiotics in the river which was mainly replenished by reclaimed water. This study showed the necessity of employing more effective advanced treatment facilities to further reduce the discharge amount of antibiotics.

关键词： antibiotics     advanced treatment     urban river     reclaimed water    

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gradients in thin films using molecularly imprinted polymer binding gels for in situ measurements of antibiotics

Ying Cui, Feng Tan, Yan Wang, Suyu Ren, Jingwen Chen

《环境科学与工程前沿（英文）》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1290-5

摘要： Abstract • Selective molecularly imprinted polymer (MIP) binding gel was prepared. • MIP-DGT showed excellent uptake performance for antibiotics. • In situ measurement of antibiotics in wastewaters via MIP-DGT was developed. • The MIP-DGT method was robust, reliable, and highly sensitive. Urban wastewater is one of main sources for the introduction of antibiotics into the environment. Monitoring the concentrations of antibiotics in wastewater is necessary for estimating the amount of antibiotics discharged into the environment through urban wastewater treatment systems. In this study, we report a novel diffusive gradient in thin films (DGT) method based on molecularly imprinted polymers (MIPs) for in situ measurement of two typical antibiotics, fluoroquinolones (FQs) and sulfonamides (SAs) in urban wastewater. MIPs show specific adsorption toward their templates and their structural analogs, resulting in the selective uptake of the two target antibiotics during MIP-DGT deployment. The uptake performance of the MIP-DGTs was evaluated in the laboratory and was relatively independent of solution pH (4.0–9.0), ionic strength (1–750 mmol/L), and dissolved organic matter (DOM, 0–20 mg/L). MIP-DGT samplers were tested in the effluent of an urban wastewater treatment plant for field trials, where three SA (sulfamethoxazole, sulfapyridine, and trimethoprim) and one FQ (ofloxacin) antibiotics were detected, with concentrations ranging from 25.50 to 117.58 ng/L, which are consistent with the results measured by grab sampling. The total removal efficiency of the antibiotics was 80.1% by the treatment plant. This study demonstrates that MIP-DGT is an effective tool for in situ monitoring of trace antibiotics in complex urban wastewaters.

关键词： Diffusive gradients in thin films     Molecularly imprinted polymers     Selective uptake     Antibiotics     Passive sampling    

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Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions

Xin Yu, Virender K. Sharma, Hui Li

《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1137-0

摘要：
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Occurrence of veterinary antibiotics in struvite recovery from swine wastewater by using a fluidized

Zhi-Long Ye, Yujun Deng, Yaoyin Lou, Xin Ye, Shaohua Chen

《环境科学与工程前沿（英文）》 2018年 第12卷 第3期 doi: 10.1007/s11783-018-1015-1

摘要： Recovering phosphorus from livestock wastewater has gained extensive attention. The residue of veterinary antibiotics in the wastewater may be present in the recovered products, thereby posing pharmacological threats to the agricultural planting and human health. This study investigated antibiotic occurrence in the struvite particles recovered from swine wastewater by using a fluidized bed. Results revealed that tetracyclines possessed significant residues in the struvite granules, with the values ranging from 195.2 mg·kg to 1995.0 mg·kg . As for fluoroquinolones, their concentrations varied from 0.4 mg·kg to 1104.0 mg·kg . Struvite particles were of various sizes and shapes and displayed different antibiotic adsorption capacities. The data also showed that the smaller granules contained much more antibiotics than the larger ones, indicating that the fluidized granulation process of struvite crystals plays an important role on the accumulation of antibiotics. For tetracyclines, organic matters and struvite adsorption exerted significant impacts on tetracyclines migration. The outcomes underscore the need to consider the residues of antibiotics in resource recovery from wastewater because they exert pharmacological impacts on the utilization of recovered products.

关键词： Antibiotic     Struvite     Phosphorus recovery     Swine wastewater     Fluidized bed    

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农田土壤抗生素污染管控建议

王娜,郭欣妍,单正军,蔡道基

《中国工程科学》 2021年 第23卷 第1期   页码 167-173 doi: 10.15302/J-SSCAE-2021.01.023

摘要：

抗生素在畜禽养殖业中发挥了重要保障作用，但畜禽粪便农用后伴生的抗生素耐药性传播风险日益显现，农田土壤抗生素及其耐药基因的风险管控工作亟待开展。本文总结了农田土壤中抗生素的污染现状，梳理了农田土壤中新兴污染物抗生素管控存在的问题，提出了农田土壤抗生素及其耐药基因的风险管控建议。研究发现，农田土壤抗生素及其耐药基因的污染风险不可忽视，但抗生素类新兴污染物尚未纳入土壤风险管控范围内。应设立严格的兽药应用监管机制，从养殖源头扼制风险的发生概率；制定有机肥中反映耐药性的控制标准，出台技术指南以规范含抗生素粪便的处置与施用，减少抗生素耐药基因进入环境的总量。同时加紧开展环境抗生素耐药性产生和转移的人类健康风险评估研究，实施农田土壤环境抗生素耐药常规监测，发挥风险评估在该类污染物风险管控工作中的作用。

关键词： 抗生素     耐药基因     农田土壤     传播风险     管控对策    

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Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

《医学前沿（英文）》 2019年 第13卷 第4期   页码 471-481 doi: 10.1007/s11684-019-0686-8

摘要： Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus . Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients.

关键词： antibiotics     tacrolimus     glucose disorders     microbiome    

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Adsorption behavior of antibiotic in soil environment: a critical review

Shiliang WANG,Hui WANG

《环境科学与工程前沿（英文）》 2015年 第9卷 第4期   页码 565-574 doi: 10.1007/s11783-015-0801-2

摘要： Antibiotics are used widely in human and veterinary medicine, and are ubiquitous in environment matrices worldwide. Due to their consumption, excretion, and persistence, antibiotics are disseminated mostly via direct and indirect emissions such as excrements, sewage irrigation, and sludge compost and enter the soil and impact negatively the natural ecosystem of soil. Most antibiotics are amphiphilic or amphoteric and ionize. A non-polar core combined with polar functional moieties makes up numerous antibiotic molecules. Because of various molecule structures, physicochemical properties vary widely among antibiotic compounds. Sorption is an important process for the environment behaviors and fate of antibiotics in soil environment. The adsorption process has decisive role for the environmental behaviors and the ultimate fates of antibiotics in soil. Multiply physicochemical properties of antibiotics induce the large variations of their adsorption behaviors. In addition, factors of soil environment such as the pH, ionic strength, metal ions, and organic matter content also strongly impact the adsorption processes of antibiotics. Review about adsorption of antibiotics on soil can provide a fresh insight into understanding the antibiotic-soil interactions. Therefore, literatures about the adsorption mechanisms of antibiotics in soil environment and the effects of environment factors on adsorption behaviors of antibiotics in soil are reviewed and discussed systematically in this review.

关键词： adsorption     antibiotics     environment factors     soil    

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Influence of hydraulic retention time on behavior of antibiotics and antibiotic resistance genes in aerobic

Jie Liao, Chaoxiang Liu, Lin Liu, Jie Li, Hongyong Fan, Jiaqi Ye, Zhichao Zeng

《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1115-6

摘要：

Longer HRT can enhance degradation rate of sulfamethoxazole in granular reactor.

Longer HRT can reduce accumulated concentrations of TCs and QNs in sludge.

Longer HRT may have increased relative abundances of ARGs in aerobic granules.

关键词： Aerobic granules     Swine wastewater     Tetracyclines     Fluoroquinolones     Sulfonamides    

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Antibiotic resistance genes in manure-amended paddy soils across eastern China: Occurrence and influencing factors

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1499-y

摘要：

• Manure fertilization resulted in antibiotic residues and increased metal contents.

关键词： Pig manure     Antibiotics     Metals     Antibiotic resistance genes     Paddy fields    

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Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China

Wentao Zhao, Ying Guo, Shuguang Lu, Pingping Yan, Qian Sui

《环境科学与工程前沿（英文）》 2016年 第10卷 第6期 doi: 10.1007/s11783-016-0868-4

摘要： Recent publications on PPCPs in surface water environment in China were reviewed. Antibiotics received more attention than other PPCPs in surface water environment. Uneven attention has been focused across different study areas in China. Sulfamethoxazole showed the most significant environmental risk in surface water. Higher risks were posed by PPCPs in sediments than in surface water. Pharmaceuticals and personal care products (PPCPs) have been regarded as an emerging problem in the surface water environment in the past few decades. In China, although related studies were initiated several years ago, an increasing number of studies on this topic have been conducted in recent years. These studies have expanded knowledge of their occurrence, behavior and associated risk in the surface water environment in China. This review compiles the most recent literature related to the studies of PPCPs in the surface water environment in China. It includes PPCP occurrence in surface water and sediments, their geographical distribution, and outcomes of the associated risk assessment. It shows that antibiotics have received much more attention in both surface water and sediments than other PPCPs. Compared to other countries; most antibiotics in the collected sediments in China showed higher contamination levels. Many more study areas have been covered in recent years; however, attention has been given to only specific areas. Environmental risk assessment based on risk quotients indicated that sulfamethoxazole presents the most significant environmental risk to relevant aquatic organisms; followed by ofloxacin, ciprofloxacin, enrofloxacin, 17α-ethynylestradiol, ibuprofen and diclofenac. Despite limited research on the environmental risk assessment of PPCPs in sediments, higher risks posed by PPCPs in the sediments rather than surface water were identified highlighting the need for further risk assessment of PPCPs in sediment samples.

关键词： Surface water     Sediment     Antibiotics     Geographical distribution     Risk assessment    

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标题 作者 时间 类型 操作

Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by

WEI Yimei,ZHANG Yuan,XU Jian,GUO Changsheng,LI Lei,FAN Wenhong

期刊论文

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

期刊论文

Decoding and quantitative detection of antibiotics by a luminescent mixed-lanthanide-organic framework

期刊论文

cellulose and κ-carrageenan composite aerogel with efficient performance in removal of fluoroquinolone antibiotics

期刊论文

Occurrence and fate of typical antibiotics in wastewater treatment plants in Harbin, North-east China

Weihua Wang, Wanfeng Zhang, Hong Liang, Dawen Gao

期刊论文

Occurrence and fate of antibiotics in advanced wastewater treatment facilities and receiving rivers in

Xinwei LI,Hanchang SHI,Kuixiao LI,Liang ZHANG,Yiping GAN

期刊论文

gradients in thin films using molecularly imprinted polymer binding gels for in situ measurements of antibiotics

Ying Cui, Feng Tan, Yan Wang, Suyu Ren, Jingwen Chen

期刊论文

Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions

Xin Yu, Virender K. Sharma, Hui Li

期刊论文

Occurrence of veterinary antibiotics in struvite recovery from swine wastewater by using a fluidized

Zhi-Long Ye, Yujun Deng, Yaoyin Lou, Xin Ye, Shaohua Chen

期刊论文

农田土壤抗生素污染管控建议

王娜,郭欣妍,单正军,蔡道基

期刊论文

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

期刊论文

Adsorption behavior of antibiotic in soil environment: a critical review

Shiliang WANG,Hui WANG

期刊论文

Influence of hydraulic retention time on behavior of antibiotics and antibiotic resistance genes in aerobic

Jie Liao, Chaoxiang Liu, Lin Liu, Jie Li, Hongyong Fan, Jiaqi Ye, Zhichao Zeng

期刊论文

Antibiotic resistance genes in manure-amended paddy soils across eastern China: Occurrence and influencing factors

期刊论文

Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China

Wentao Zhao, Ying Guo, Shuguang Lu, Pingping Yan, Qian Sui

期刊论文