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Astrocytes in depression and Alzheimer’s disease

《医学前沿(英文)》 2021年 第15卷 第6期   页码 829-841 doi: 10.1007/s11684-021-0875-0

摘要: Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In clinical cases, multiple chronic brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer’s disease (AD). For years, complex pathological conditions driven by depression and AD have been widely perceived to contribute to a high risk of disability, resulting in gradual loss of self-care ability, lower life qualities, and vast burden on human society. Interestingly, correlational research on depression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease. As a kind of multifunctional glial cell in the CNS, astrocytes maintain physiological function via supporting neuronal cells, modulating pathologic niche, and regulating energy metabolism. Mounting evidence has shown that astrocytic dysfunction is involved in the progression of depression and AD. We herein review the current findings on the roles and mechanisms of astrocytes in the development of depression and AD, with an implication of potential therapeutic avenue for these diseases by targeting astrocytes.

关键词: astrocytes     depression     Alzheimer’s disease     roles     mechanisms    

Implications of astrocytes in neurovascular coupling

You ZHOU MD, Chang-Kai SUN MD,

《医学前沿(英文)》 2010年 第4卷 第1期   页码 43-45 doi: 10.1007/s11684-010-0019-4

摘要: Normal brain function requires continuous supply of oxygen and glucose in a strict manner. The close spatial and temporal relationship between neural activity and cerebral blood flow (CBF) is termed as neurovascular coupling, which is dependent or not dependent on astrocytes. The increase in flow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells and act at different levels of the cerebral vasculature. More studies are needed for further understanding the precise mechanisms underlying neurovascular coupling, especially the implications of astrocytes.

关键词: cerebral blood flow     neurovascular coupling     astrocyte    

标题 作者 时间 类型 操作

Astrocytes in depression and Alzheimer’s disease

期刊论文

Implications of astrocytes in neurovascular coupling

You ZHOU MD, Chang-Kai SUN MD,

期刊论文