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期刊论文 5

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2019 1

2018 1

2017 2

2007 1

关键词

智能感知;主动视觉;听觉感知;言语感知;自主学习 1

鸡尾酒会问题;计算听觉场景分析;非负矩阵分解;排列不变性训练;多说话人语音处理 1

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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

《医学前沿(英文)》 2007年 第1卷 第4期   页码 429-432 doi: 10.1007/s11684-007-0084-5

摘要: The aim of this research was to investigate the variations of P50 auditory sensory gating (P50) in normal healthy adults and the first onset schizophrenics. By using the American Nicolet Bravo electromyography/evoked potential (EMG/EP) system, P50 was measured with conditioning-testing paradigm (paired-click stimuli S1 and S2 were used) in 58 first onset schizophrenics and 108 healthy adults, and the Positive and Negative Syndrome Scale (PANSS) was applied. The following three conclusions have been reached. (1) In normal control (NC) group, measured from central, anterior and posterior zone (Cz, Fz and Pz respectively), there were no statistical differences (>0.05) between S1 and S2 evoked P50 peak latencies (S1-P50 and S2-P50); the amplitudes of S2-P50 [(2.2±1.4), (2.3±1.5) and (2.1±1.4) μV respectively] reduced significantly as compared with S1-P50 [(5.6±3.3), (5.6±3.9) and (4.9±2.8) μV respectively] (<0.01); the S2/S1 ration, S1-S2 difference, and 100 (1-S2/S1) had no statistical differences (>0.05). (2) Compared with NC, the schizophrenic group significantly showed lower S1-P50 amplitudes (<0.01, except at Pz in which = 2.030, = 0.042), higher S2-P50 amplitudes, higher S2/S1 ratio, lower S1-S2 difference, and more decreased 100 (1-S2/S1) (<0.01) at Cz, Fz and Pz. (3) No significant correlations were found among S2/S1 ratio, S1-S2, 100 (1-S2/S1) of sensory gating and PANSS (>0.05) in schizophrenic group. The first onset schizophrenics had sensory gating deficits, which could be quantified by P50.

关键词: anterior     Positive     S2-P50     schizophrenic     EMG/EP    

Behavioral methods for the functional assessment of hair cells in zebrafish

null

《医学前沿(英文)》 2017年 第11卷 第2期   页码 178-190 doi: 10.1007/s11684-017-0507-x

摘要:

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.

关键词: zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

《医学前沿(英文)》 2019年 第13卷 第6期   页码 705-712 doi: 10.1007/s11684-019-0703-y

摘要: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the two signaling pathways in the mouse cochlea remains largely unknown. Here, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear development stages. We found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can drive the quiescent Lgr5 cells to re-enter the cell cycle and differentiate into extra HCs, whereas the upregulation of Notch1 expression did not affect the proliferation or differentiation of otic progenitor cells. No effect was observed on the upregulation or downregulation of Notch1 in Lgr5 cells from E10.5 to E14.5. We concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent and Notch1 serves as a negative regulator for Lgr5 progenitor activation during cochlear differentiation. Our findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear development.

关键词: inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

鸡尾酒会问题的技术回顾、当前进展及未来挑战 Review

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

《信息与电子工程前沿(英文)》 2018年 第19卷 第1期   页码 40-63 doi: 10.1631/FITEE.1700814

摘要: 介绍了以下内容:传统的单通道情况下的技术,如计算听觉场景分析(computational auditory scene analysis, CASA)、非负矩阵分解(non-negative matrix

关键词: 鸡尾酒会问题;计算听觉场景分析;非负矩阵分解;排列不变性训练;多说话人语音处理    

AI2.0时代的类人与超人感知:研究综述与趋势展望 Review

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

《信息与电子工程前沿(英文)》 2017年 第18卷 第1期   页码 58-67 doi: 10.1631/FITEE.1601804

摘要: 感知是智能系统与现实世界的交互界面。如果没有复杂而灵活的感知能力,就不可能创造出高级的人工智能(AI)系统。最近,潘云鹤院士提出了AI 2.0的概念,其最重要的特征就是未来的AI系统应拥有类人甚至超人的智能感知能力。本文简要回顾了不同智能感知领域的研究现状,包括视觉感知、听觉感知、言语感知、感知信息处理与学习引擎等方面。在此基础上,论文对即将到来的AI 2.0时代智能感知领域需要大力研究发展的重点方向进行了展望,包括:(1)类人和超人的主动视觉;(2)自然声学场景的听知觉感知;(3)自然交互环境的言语感知及计算;(4)面向媒体感知的自主学习;(5)大规模感知信息处理与学习引擎;(6)城市全维度智能感知推理引擎。这些研究方向应在未来AI 2.0的研究规划中进行重点布局。

关键词: 智能感知;主动视觉;听觉感知;言语感知;自主学习    

标题 作者 时间 类型 操作

P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

期刊论文

Behavioral methods for the functional assessment of hair cells in zebrafish

null

期刊论文

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

期刊论文

鸡尾酒会问题的技术回顾、当前进展及未来挑战

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

期刊论文

AI2.0时代的类人与超人感知:研究综述与趋势展望

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

期刊论文