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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

《医学前沿(英文)》 2022年 第16卷 第5期   页码 773-783 doi: 10.1007/s11684-021-0902-1

摘要: The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitors (ICIs) in China has not been quantified. This cross-sectional study was conducted to estimate the number of Chinese cancer patients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immune checkpoint inhibitor clinical practice guideline of the Chinese Society of Clinical Oncology. A total of 11 ICIs were recommended for 17 cancer types. The estimated number of eligible patients annually was 1 290 156 (55.18%), which included 888 738 males (60.05%) and 400 468 females (46.67%). The estimated number of responders annually was 448 972 (19.20%), which included 309 023 males (20.88%) and 139 764 females (16.29%). Gastric cancer (n=291 000, 12.45%), non-small-cell lung cancer (n=289 629, 12.39%), and hepatocellular carcinoma (n=277 100, 11.85%) were the top three cancer types with the highest number of eligible patients. Non-small-cell lung cancer (n=180 022, 7.70%), hepatocellular carcinoma (n=75 648, 3.24%), and small-cell lung cancer (n=64 362, 2.75%) were the top three cancer types with the highest number of responders. In conclusion, ICIs provide considerable benefit in Chinese cancer patients under optimal estimation.

关键词: benefit     China     eligibility     immune checkpoint inhibitor     public health    

泰州大桥施工营地太阳能利用综合效益分析

丁志群,徐俊,李明

《中国工程科学》 2010年 第12卷 第4期   页码 100-103

摘要:

以泰州大桥北塔,北锚施工营地为对象,从粉尘、SO2排放以及能源消耗等方面,分析了太阳能利用对比于普通燃煤锅炉对环境的影响,发现太阳能利用能明显地改善营地的环境。

关键词: 泰州大桥施工营地     太阳能     综合效益(环境效益、经济效益)    

Cost-benefit analysis of China’s national air pollution control plan

Jing ZHANG, Hongqiang JIANG, Wei ZHANG, Guoxia MA, Yanchao WANG, Yaling LU, Xi HU, Jia ZHOU, Fei PENG, Jun BI, Jinnan WANG

《工程管理前沿(英文)》 2019年 第6卷 第4期   页码 524-537 doi: 10.1007/s42524-019-0074-8

摘要: China’s rapid economic growth has caused severe air pollution and public health problems. Therefore, the Chinese government launched the National Air Pollution Control Plan (hereinafter referred to as the “Air Plan”) in 2013–2017 to improve air quality and safeguard public health. In this study, an analytical framework for a cost-benefit analysis applicable to China was constructed, and the costs and benefits of the implementation of the “Air Plan” in 30 cities and provinces in China from 2013 to 2017 were evaluated. Results show that the total cost of implementation of the “Air Plan” is 1.6511 trillion RMB. The benefits of air quality improvement were determined to be 2.4691 trillion RMB through the willingness-to-pay method to calculate the economic loss of premature deaths. The net benefit related to the implementation of the “Air Plan” was 818 billion RMB. The public health benefit of air quality improvement was 1.5 times the cost of the nationwide implementation of the “Air Plan”. At the provincial level, net benefits that reach 279.3 billion RMB were the highest in Guangdong, whereas the benefit-cost ratio, where the benefit was 5.5 times the cost, was the highest in Fujian. Estimations in this study can serve as a reference for China in formulating similar environmental policies and implementing the “3-year Plan to Defend the Blue Sky”. In addition, these estimations have practical significance for advancing the long-term effective mechanisms of the cost-benefit analysis of China’s environmental policies.

关键词: Air Plan     cost-benefit analysis     health benefits     environmental policy    

Collaborative control of fine particles and ozone required in China for health benefit

《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1692-2

摘要:

● Increased DAAO offsets 3/4 of the decrease of DAAP in 2013–2020.

关键词: Excess deaths     Long-term exposure     Fine particle     Ozone    

Reactive power deployment and cost benefit analysis in DNO operated distribution electricity markets

Atma Ram GUPTA,Ashwani KUMAR

《能源前沿(英文)》 2019年 第13卷 第1期   页码 86-98 doi: 10.1007/s11708-017-0456-8

摘要: The aim of this paper is to analyze unbalanced radial distribution systems (UBRDS) with the distribution static compensator (D-STATCOM). The main objectives of this paper are D-STATCOM allocation in UBRDS with an objective of providing reactive power support to enhance voltage profile and reduce line losses of the distribution network, determination of optimal D-STATCOM rating subjected to minimization of total cost, and impact of D-STATCOM placement on improving power factor and savings in cost of energy loss. The analysis is conducted on a large industrial load model with light, medium and high loading scenarios. Further, the impact of load growth is also considered for better planning of the power distribution system. The results are obtained on standard 25-bus UBRDS to check the feasibility of the proposed methodology.

关键词: unbalanced distribution system     D-STATCOM     voltage sensitivity index     load models     load growth     distribution network operator (DNO)    

Determination of 27 pharmaceuticals and personal care products (PPCPs) in water: The benefit of isotope

Xueqi Fan, Jie Gao, Wenchao Li, Jun Huang, Gang Yu

《环境科学与工程前沿(英文)》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1187-3

摘要: • Isotope dilution method was developed for the determination of 27 PPCPs in water. • The established method was successfully applied to different types of water samples. • The correction effect of corresponding 27 ILSs over 70 d was investigated. • Benefit of isotopic dilution method was illustrated for three examples. Pharmaceuticals and personal care products (PPCPs) are a unique group of emerging and non-persistent contaminants. In this study, 27 PPCPs in various water samples were extracted by solid phase extraction (SPE), and determined by isotope dilution method using liquid chromatography coupled to tandem triple quadruple mass spectrometer (LC-MS/MS). A total of 27 isotopically labeled standards (ILSs) were applied to correct the concentration of PPCPs in spiked ultrapure water, drinking water, river, effluent and influent sewage. The corrected recoveries were 73%–122% with the relative standard deviation (RSD)<16%, except for acetaminophen. The matrix effect for all kinds of water samples was<22% and the method quantitation limits (MQLs) were 0.45–8.6 ng/L. The developed method was successfully applied on environmental water samples. The SPE extracts of spiked ultrapure water, drinking water, river and wastewater effluent were stored for 70 days, and the ILSs-corrected recoveries of 27 PPCPs were obtained to evaluate the correction ability of ILSs in the presence of variety interferences. The recoveries of 27 PPCPs over 70 days were within the scope of 72%–140% with the recovery variation<37% in all cases. The isotope dilution method seems to be of benefit when the extract has to be stored for long time before the instrument analysis.

关键词: Pharmaceuticals and personal care products (PPCPs)     Isotopically labeled standard (ILSs)     Water     Solid-phase extraction (SPE)     LC-MS/MS    

高速公路项目社会经济效益的产生机制及其评价研究

王宇宁,运迎霞,范志清

《中国工程科学》 2012年 第14卷 第10期   页码 97-102

摘要:

基于系统工程的思想,通过分析高速公路社会经济效益产生的机制,建立了区域经济—公路交通发展系统动力学模型,以天津市津蓟高速公路为例,通过系统仿真误差检验,证实了该系统动力学模型的仿真效果较好、性能稳定。通过已建—未建高速公路系统仿真结果的有无对比,计算并预测出了津蓟高速公路2003—2013年各年的社会经济效益,从而实现了高速公路项目社会经济效益评价的定量化目标,为今后类似项目的开展提供了理论指导。

关键词: 高速公路项目     社会经济效益     评价     系统动力学    

Reducing CO emissions from the rebalancing operation of the bike-sharing system in Beijing

《工程管理前沿(英文)》 2023年 第10卷 第2期   页码 262-284 doi: 10.1007/s42524-021-0168-y

摘要: With the development of the bike-sharing system (BSS) and the introduction of green and low carbon development, the environmental impacts of BSS had received increasing attention in recent years. However, the emissions from the rebalancing of BSS, where fossil-fueled vehicles are commonly used, are usually neglected, which goes against the idea of green travel in a sharing economy. Previous studies on the bike-sharing rebalancing problem (BRP), which is considered NP-hard, have mainly focused on algorithm innovation instead of improving the solution model, thereby hindering the application of many existing models in large-scale BRP. This study then proposes a method for optimizing the CO2 emissions from BRP and takes the BSS of Beijing as a demonstration. We initially analyze the spatial and temporal characteristics of BSS, especially the flow between districts, and find that each district can be independently rebalanced. Afterward, we develop a rebalancing optimization model based on a partitioning strategy to avoid deciding the number of bikes being loaded or unloaded at each parking node. We then employ the tabu search algorithm to solve the model. Results show that (i) due to over launch and lack of planning in rebalancing, the BSS in Beijing shows great potential for optimization, such as by reducing the number of vehicle routes, CO2 emissions, and unmet demands; (ii) the CO2 emissions of BSS in Beijing can be reduced by 57.5% by forming balanced parking nodes at the end of the day and decreasing the repetition of vehicle routes and the loads of vehicles; and (iii) the launch amounts of bikes in specific districts, such as Shijingshan and Mentougou, should be increased.

关键词: bike-sharing     CO2 emissions     environmental benefit     partitioning strategy     rebalancing problem    

Mass and heat balance calculations and economic evaluation of an innovative biomass pyrolysis project

Quanyuan WEI, Yongshui QU, Tianwei TAN

《化学科学与工程前沿(英文)》 2011年 第5卷 第3期   页码 355-361 doi: 10.1007/s11705-010-0567-9

摘要: Biomass can be converted into flammable gas, charcoal, wood vinegar, wood tar oil and noncombustible materials with thermo-chemical pyrolysis reactions. Many factors influence these processes, such as the properties of the raw materials, and temperature control and these will affect the products that are produced. Based on the data from a straw pyrolysis demonstration project, the mass and heat balance of the biomass pyrolysis process were analyzed. The statistical product and service solutions (SPSS) statistical method was used to analyze the data which were monitored on-site. A cost-benefit analysis was then used to study the viability of commercializing the project. The analysis included net present value, internal rate of return and investment payback period. These results showed that the straw pyrolysis project has little risk, and will produce remarkable economic benefits.

关键词: mass balance     heat balance     biomass pyrolysis     economic benefit    

基于成本收益分析的集成测试序列生成优化方法 Research Article

孟繁祎1,王莹1,2,于海1,朱志良1

《信息与电子工程前沿(英文)》 2022年 第23卷 第5期   页码 692-714 doi: 10.1631/FITEE.2100466

摘要: 集成测试是面向对象软件测试的重要组成部分。传统的类级集成测试顺序研究策略大多围绕如何降低测试成本开展工作,并未考虑赋予可靠性风险较大的节点较高测试优先级,从而影响软件测试效率。本文提出一种兼顾测试成本与测试效率的方法生成集成测试序列。根据软件在不同场景下的运行状态,将其映射成多层动态执行网络(multi-layer dynamic execution network,MDEN)。借助该网络模型与概率风险评估方法为软件中每一个类赋予风险权重。利用成本收益分析方法,在生成测试用例的过程中保证两条原则:为高风险的类赋予较高权重,同时最小化测试桩复杂度。在此基础上,分析测试序列对软件系统总体运行风险的影响,从而提出评估测试序列优劣的度量方案。通过与现有算法的实验对比分析,证明所提算法生成的类级集成测试序列能有效降低测试代价。最后,将所提算法实现为自动生成集成测试序列的开源工具ITOsolution。

关键词: 集成测试序列;成本收益分析;概率风险分析;复杂网络    

ENTREPRENEURIAL OPPORTUNITY, VALUE EVOLUTION, AND ORGANIZATIONAL INTEGRATION OF PROFESSIONAL FARMER ENTREPRENEURSHIP: A MULTI-CASE COMPARISON IN CHINA

《农业科学与工程前沿(英文)》 2023年 第10卷 第1期   页码 135-148 doi: 10.15302/J-FASE-2022464

摘要:

● The choice of a modern agriculture project was found to be rational for professional farmers to reduce interference from non-market factors. The success of this project is due to its capacity to successfully fill the structural hole in the market transaction network.

关键词: Benefit-linked mechanism     featured agriculture     organizational integration     professional farmers     rural cooperative     structural hole theory    

雅鲁藏布江水能开发

徐大懋,陈传友,梁维燕

《中国工程科学》 2002年 第4卷 第12期   页码 47-52

摘要:

阐述了雅鲁藏布江(以下简称雅江)“大拐弯”处水能开发方案。工程分3期,一期送电东南亚,逐步积累资金;二、三期实现西电东送。雅江工程无需考虑防洪、航运和移民,单位千瓦投资将少于三峡水利工程。雅江工程可实现4个世界之最,不仅对促进西藏和我国的经济可持续发展有巨大战略意义,在国际上也将受到广泛的支持,并产生巨大的影响。主张对工程中存在的困难和问题进行认真的分析和论证,以作出科学的结论。

关键词: 雅鲁藏布江     水力资源     开发     投资     效益    

Development of an integrated policy making tool for assessing air quality and human health benefits of air pollution control

Xuezhen QIU,Yun ZHU,Carey JANG,Che-Jen LIN,Shuxiao WANG,Joshua FU,Junping XIE,Jiandong WANG,Dian DING,Shicheng LONG

《环境科学与工程前沿(英文)》 2015年 第9卷 第6期   页码 1056-1065 doi: 10.1007/s11783-015-0796-8

摘要: Efficient air quality management is critical to protect public health from the adverse impacts of air pollution. To evaluate the effectiveness of air pollution control strategies, the US Environmental Protection Agency (US EPA) has developed the Software for Model Attainment Test-Community Edition (SMAT-CE) to assess the air quality attainment of emission reductions, and the Environmental Benefits Mapping and Analysis Program-Community Edition (BenMAP-CE) to evaluate the health and economic benefits of air quality improvement respectively. Since scientific decision-making requires timely and coherent information, developing the linkage between SMAT-CE and BenMAP-CE into an integrated assessment platform is desirable. To address this need, a new module linking SMAT-CE to BenMAP-CE has been developed and tested. The new module streamlines the assessment of air quality and human health benefits for a proposed air pollution control strategy. It also implements an optimized data gridding algorithm which significantly enhances the computational efficiency without compromising accuracy. The performance of the integrated software package is demonstrated through a case study that evaluates the air quality and associated economic benefits of a national-level control strategy of PM . The results of the case study show that the proposed emission reduction reduces the number of nonattainment sites from 379 to 25 based on the US National Ambient Air Quality Standards, leading to more than US$334 billion of economic benefits annually from improved public health. The integration of the science-based software tools in this study enhances the efficiency of developing effective and optimized emission control strategies for policy makers.

关键词: air quality assessment     human health benefit     economic benefit     air quality attainment assessment     air pollution control strategy     decision support system    

Techno-economic characteristics of wastewater treatment plants retrofitted from the conventional activated sludge process to the membrane bioreactor process

《环境科学与工程前沿(英文)》 doi: 10.1007/s11783-021-1483-6

摘要:

While a growing number of wastewater treatment plants (WWTPs) are being retrofitted from the conventional activated sludge (CAS) process to the membrane bioreactor (MBR) process, the debate on the techno-economy of MBR vs. CAS has continued and calls for a thorough assessment based on techno-economic valuation.

关键词: Membrane bioreactor (MBR)     Conventional activated sludge (CAS)     Cost-benefit analysis     Data envelopment analysis     Net profit    

An assessment of the potential health benefits of realizing the goals for PM

Guoxia MA,Jinnan WANG,Fang YU,Yanshen ZHANG,Dong CAO

《环境科学与工程前沿(英文)》 2016年 第10卷 第2期   页码 288-298 doi: 10.1007/s11783-014-0738-x

摘要: As a response to the severe air quality problems in China, the Chinese Ministry of Environmental Protection in 2012 issued an updated (GB3095-2012), which set a stricter grade II PM standard. A successful implementation of this standard will have an impact on human health through reduction of exposure to air pollution in the population. Using the methods of adjusted human capital and value of statistical life, the authors in this article estimate the economic impact of a successful implementation of the updated on human health in China. The key results are: 1) The human health benefits from reaching the updated standard for PM would equal CNY 51.1 billion using adjusted human capital, accounting for 18.5% of total human health costs in China, and CNY 83.5 billion using the value of a statistical life; 2) the benefit of reaching the updated standard for PM is highest in the east coastal areas and gradually declines for more Western provinces; and 3) the marginal benefit of public health increases as the environmental quality standard PM improves. If the annual concentration of PM were to be reduced from the target number in the original grade II standard to that in the updated standard, the mortality rate of long-term exposure would be reduced by 6.5% due to reduced chronic exposure. In addition, if the annual concentration were to be reduced further from updated grade II to grade I standard, the mortality rate for long-term exposure would be lowered by 32.8%.

关键词: air quality     health benefit     Ambient Air Quality Standard     PM10     China    

标题 作者 时间 类型 操作

Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

期刊论文

泰州大桥施工营地太阳能利用综合效益分析

丁志群,徐俊,李明

期刊论文

Cost-benefit analysis of China’s national air pollution control plan

Jing ZHANG, Hongqiang JIANG, Wei ZHANG, Guoxia MA, Yanchao WANG, Yaling LU, Xi HU, Jia ZHOU, Fei PENG, Jun BI, Jinnan WANG

期刊论文

Collaborative control of fine particles and ozone required in China for health benefit

期刊论文

Reactive power deployment and cost benefit analysis in DNO operated distribution electricity markets

Atma Ram GUPTA,Ashwani KUMAR

期刊论文

Determination of 27 pharmaceuticals and personal care products (PPCPs) in water: The benefit of isotope

Xueqi Fan, Jie Gao, Wenchao Li, Jun Huang, Gang Yu

期刊论文

高速公路项目社会经济效益的产生机制及其评价研究

王宇宁,运迎霞,范志清

期刊论文

Reducing CO emissions from the rebalancing operation of the bike-sharing system in Beijing

期刊论文

Mass and heat balance calculations and economic evaluation of an innovative biomass pyrolysis project

Quanyuan WEI, Yongshui QU, Tianwei TAN

期刊论文

基于成本收益分析的集成测试序列生成优化方法

孟繁祎1,王莹1,2,于海1,朱志良1

期刊论文

ENTREPRENEURIAL OPPORTUNITY, VALUE EVOLUTION, AND ORGANIZATIONAL INTEGRATION OF PROFESSIONAL FARMER ENTREPRENEURSHIP: A MULTI-CASE COMPARISON IN CHINA

期刊论文

雅鲁藏布江水能开发

徐大懋,陈传友,梁维燕

期刊论文

Development of an integrated policy making tool for assessing air quality and human health benefits of air pollution control

Xuezhen QIU,Yun ZHU,Carey JANG,Che-Jen LIN,Shuxiao WANG,Joshua FU,Junping XIE,Jiandong WANG,Dian DING,Shicheng LONG

期刊论文

Techno-economic characteristics of wastewater treatment plants retrofitted from the conventional activated sludge process to the membrane bioreactor process

期刊论文

An assessment of the potential health benefits of realizing the goals for PM

Guoxia MA,Jinnan WANG,Fang YU,Yanshen ZHANG,Dong CAO

期刊论文