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化工 1

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支架 1

机械力转导 1

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Co anchored on porphyrinic triazine-based frameworks with excellent biocompatibility for conversion of

《化学科学与工程前沿(英文)》 2022年 第16卷 第12期   页码 1761-1771 doi: 10.1007/s11705-022-2195-6

摘要: Microbial electrosynthesis is a promising alternative to directly convert CO2 into long-chain compounds by coupling inorganic electrocatalysis with biosynthetic systems. However, problems arose that the conventional electrocatalysts for hydrogen evolution may produce extensive by-products of reactive oxygen species and cause severe metal leaching, both of which induce strong toxicity toward microorganisms. Moreover, poor stability of electrocatalysts cannot be qualified for long-term operation. These problems may result in poor biocompatibility between electrocatalysts and microorganisms. To solve the bottleneck problem, Co anchored on porphyrinic triazine-based frameworks was synthesized as the electrocatalyst for hydrogen evolution and further coupled with Cupriavidus necator H16. It showed high selectivity for a four-electron pathway of oxygen reduction reaction and low production of reactive oxygen species, owing to the synergistic effect of Co–Nx modulating the charge distribution and adsorption energy of intermediates. Additionally, low metal leaching and excellent stability were observed, which may be attributed to low content of Co and the stabilizing effect of metalloporphyrins. Hence, the electrocatalyst exhibited excellent biocompatibility. Finally, the microbial electrosynthesis system equipped with the electrocatalyst successfully converted CO2 to poly-β-hydroxybutyrate. This work drew up a novel strategy for enhancing the biocompatibility of electrocatalysts in microbial electrosynthesis system.

关键词: microbial electrosynthesis     hydrogen evolution reaction     metalloporphyrins     biocompatibility     CO2 conversion    

Anodization of titanium alloys for orthopedic applications

Merve İzmir, Batur Ercan

《化学科学与工程前沿(英文)》 2019年 第13卷 第1期   页码 28-45 doi: 10.1007/s11705-018-1759-y

摘要:

In recent years, nanostructured oxide films on titanium alloy surfaces have gained significant interest due to their electrical, catalytic and biological properties. In literature, there is variety of different approaches to fabricate nanostructured oxide films. Among these methods, anodization technique, which allows fine-tuning of oxide film thickness, feature size, topography and chemistry, is one of the most popular approaches to fabricate nanostructured oxide films on titanium alloys, and it has been widely investigated for orthopedic applications. Briefly, anodization is the growth of a controlled oxide film on a metallic component attached to the anode of an electrochemical cell. This review provides an overview of the anodization technique to grow nanostructured oxide films on titanium and titanium alloys and summarizes the interactions between anodized titanium alloy surfaces with cells in terms of cellular adhesion, proliferation and differentiation. It will start with summarizing the mechanism of nanofeatured oxide fabrication on titanium alloys and then switch its focus on the latest findings for anodization of titanium alloys, including the use of fluoride free electrolytes and anodization of 3D titanium foams. The review will also highlight areas requiring further research to successfully translate anodized titanium alloys to clinics for orthopedic applications.

关键词: titanium alloys     anodization     biocompatibility     orthopedics    

组织工程模板中的生物相容性途径 Perspective

David F. Williams

《工程(英文)》 2018年 第4卷 第2期   页码 286-290 doi: 10.1016/j.eng.2018.03.007

摘要:

组织工程通过系统结合分子信号和力学信号对特定靶细胞进行有意可控刺激以组建新的组织,通常需要借助由生物材料构建的结构传递这些信号,并对生成的组织块塑形。这些结构之前被称为支架,如今被更准确地命名为模板,其规范却难以定义,主要因为该规范必须涉及为细胞组建新组织提供适宜的微环境,以及细胞与模板材料的相互作用符合构建新型可存活组织的需求。这些特点统称为生物相容性。然而,传统生物相容性的理论和公认机制(大多通过可移植的医学装置进行实验得出)不足以解释在组织工程过程中的现象。本文作者近期在特定的基于材料、生物学的途径方面重新定义了生物相容性。本文以上述途径为前提讨论了组织工程生物相容性的机制。

关键词: 生物材料     支架     机械力转导     炎症     拓扑    

A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

《化学科学与工程前沿(英文)》 2017年 第11卷 第2期   页码 143-153 doi: 10.1007/s11705-017-1632-4

摘要: Shape memory polymers (SMPs) are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applications are highlighted.

关键词: shape memory polymer     biodegradability     biocompatibility     biomedical application     bile acids    

Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

Ana Mora-Boza, Francisco J. Aparicio, María Alcaire, Carmen López-Santos, Juan P. Espinós, Daniel Torres-Lagares, Ana Borrás, Angel Barranco

《化学科学与工程前沿(英文)》 2019年 第13卷 第2期   页码 330-339 doi: 10.1007/s11705-019-1803-6

摘要: Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.

关键词: plasma polymers     conformal plasma deposition     chlorhexidine     bactericide     PDMS     biocompatibility    

张雷:亲水生物相容性新材料(2020年1月10日)

张雷(高级职称)

2020年03月13日

关键词: 化工    

标题 作者 时间 类型 操作

Co anchored on porphyrinic triazine-based frameworks with excellent biocompatibility for conversion of

期刊论文

Anodization of titanium alloys for orthopedic applications

Merve İzmir, Batur Ercan

期刊论文

组织工程模板中的生物相容性途径

David F. Williams

期刊论文

A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

期刊论文

Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

Ana Mora-Boza, Francisco J. Aparicio, María Alcaire, Carmen López-Santos, Juan P. Espinós, Daniel Torres-Lagares, Ana Borrás, Angel Barranco

期刊论文

张雷:亲水生物相容性新材料(2020年1月10日)

张雷(高级职称)

2020年03月13日

会议视频