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Selective oxidation of o -nitrotoluene to o -nitrobenzaldehyde with metalloporphyrins as biomimetic catalysts

Xinling WANG, Yuanbin SHE,

《化学科学与工程前沿（英文）》 2009年 第3卷 第4期   页码 453-456 doi: 10.1007/s11705-009-0167-8

摘要： Selective oxidation of -nitrotoluene to -nitrobenzaldehyde with metalloporphyrins as biomimetic catalysts was studied. The peripheral substituent around porphyrin rings and various process parameters of NaOH concentration, reaction temperature, reaction time and oxygen pressure all affect the selectivity of -nitrobenzaldehyde. Further, 82.0% selectivity of -nitrobenzaldehyde was achieved under the optimum conditions: 1.0×10mol•L of T(-NO)PPFeCl catalyst, 2.5mol•L of NaOH, 0.2mol•L of -nitrotoluene, 45°C and 2.0MPa for 6h.

关键词： -nitrobenzaldehyde     temperature     biomimetic     selectivity     pressure    

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Bioinspired and biomimetic membranes for water purification and chemical separation: A review

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1412-8

摘要：

•The history of biological and artificial water channels is reviewed.

关键词： Aquaporins     Artificial water channels     Biomimetic membranes     Chemical separation and water purification    

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Preparation, with graphene, of novel biomimetic self-healing microcapsules with high thermal stability

《结构与土木工程前沿（英文）》   页码 1188-1198 doi: 10.1007/s11709-023-0027-5

摘要： This paper reports a comparative study of microcapsules with enhanced thermal stability and electrical conductivity inspired by the bionic thermal insulation of birds’ feathers for self-healing aged asphalt. The work is based on an in situ polymerization with composite shell components of graphene and hexamethoxymethylmelamine resin. By using graphene, microcapsules with rough surfaces are achieved, improving the interface between microcapsules and asphalt. In addition, the microcapsules’ initial thermal decomposition temperature is appropriately high, so that the stability of the microcapsule in the asphalt highway system is protected. The proportion of graphene in the microcapsule shell can regulate the microcapsule’s heat resistance because graphene modifies the shell’s structural makeup. Additionally, the microcapsules’ electrical conductivity is relatively high. The self-healing capability of bitumen sharply increases, providing benefit to the effect of microcapsules on the properties of aged asphalt.

关键词： graphene     microcapsule     bitumen     heat insulation     conductivity    

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Biomimetic mineralization and cytocompatibility of nanorod hydroxyapatite/graphene oxide composites

Peizhen Duan, Juan Shen, Guohong Zou, Xu Xia, Bo Jin

《化学科学与工程前沿（英文）》 2018年 第12卷 第4期   页码 798-805 doi: 10.1007/s11705-018-1708-9

摘要： Nanorod hydroxyapatite (NRHA)/graphene oxide (GO) composites with weight ratios of 0.4, 1.5, and 5 have been fabricated by a facile ultrasonic-assisted method at room temperature and atmospheric pressure. The chemical structure properties and morphology of the composites were characterized by field emission source scanning electron microscope, X-ray diffraction, transmission electron microscopy, and high-resolution transmission electron microscopy. The results indicate that the NNRHA/GO composites have an irregular surface with different degree wrinkles and are stable, and NRHA are well combined with GO. In addition, the biomimetic mineralization mechanism of hydroxyapatite on the NNRHA/GO composites in simulated body fluid (SBF) is presented. The presence of a bone-like apatite layer on the composite surface indicate that the NNRHA/GO composites facilitate the nucleation and growth of hydroxyapatite crystals in SBF for biomimetic mineralization. Moreover, the NNRHA-1.5/GO composite and pure GO were cultured with MC3T3-E1 cells to investigate the proliferation and adhesion of cells. In vitro cytocompatibility evaluation demonstrated that the NNRHA/GO composite can act as a good template for the growth and adhesion of cells. Therefore, the NNRHA/GO composite could be applied as a GO-based, free-template, non-toxic, and bioactive composite to substitute for a damaged or defect bone.

关键词： hydroxyapatite     graphene oxide     biomimetic mineralization     cytocompatibility    

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生物材料的仿生构思

姚康德,沈峰

《中国工程科学》 2000年 第2卷 第6期   页码 16-20

摘要：

过去30年里，生物材料的研究取得了显著成就，但从临床效果看，其与宿主相互作用亟待改善；哪怕是有些应用于长期埋植体内的替代物，常被机体视为异物，从而启迪人们不要仅着眼于从材料的物化性能方面构思生物材料。文章从蛋白质、糖类和脱氧核糖核酸与材料的关系出发，以细胞作为仿生生物材料的蓝本，从分子和细胞水平讨论了生物特异性材料设计，人工细胞外基质的仿生化途径以及通过材料对细胞编程凋亡的调控等方面的研究思路；试图从生命科学的广度和柔性出发，提出在不同层次和水平上进行仿生，从事生物材料设计，解决生物材料与生物体复杂接口问题，使生物材料向智能化和环境友好化发展。

关键词： 生物材料     仿生     人工细胞外基质    

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Roles of glutathione and L-cysteine in the biomimetic green synthesis of CdSe quantum dots

Ling-Li Li, Yin-Hua Cui, Jie-Jie Chen, Han-Qing Yu

《环境科学与工程前沿（英文）》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0948-0

摘要： Biological synthesis of quantum dots (QDs) as an environmental-friendly and facile preparation method has attracted increasing interests. However, it is difficult to distinguish the roles of bio-thiols in QDs synthesis process because of the complex nature in organisms. In this work, the CdSe QDs synthesis conditions in organisms were reconstructed by using a simplified in vitro approach to uncover the roles of two small bio-thiols in the QDs formation. CdSe QDs were synthesized with glutathione (GSH) and L-cysteine (Cys) respectively. Compared with Cys at the same molar concentration, the CdSe QDs synthesized by GSH had a larger and broader particle size distribution with improved optical properties and crystal structure. Furthermore, quantum chemical calculations indicate that the stronger Cd2+ binding capacity of GSH contributed a lot to the CdSe QDs formation despite of the greater capability Cys for selenite reduction. This work clearly demonstrates the different roles of small thiols in the Cd2+ stabilization in the environment and biomimetic QDs synthesis process.

关键词： CdSe     Quantum dots (QDs)     Biomimetic synthesis     Bio-thiols     Glutathione (GSH)     Cysteine (Cys)    

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水处理仿生膜研究进展

曾艳军,张林,陈欢林

《中国工程科学》 2014年 第16卷 第7期   页码 10-16

摘要：

本文首先介绍了细胞膜中磷脂双分子层与膜蛋白的结构以及水快速传输的机理。在此基础上分别对以膜蛋白、碳纳米管和人造有机纳米孔道为水通道的仿生膜研究进展进行了综述，着重阐述了以膜蛋白为水通道的仿生膜中两性嵌段共聚物基质的优点、规模化制备面临的问题；以碳纳米管为水通道的仿生膜中水快速传输的机理与膜的制备方法；以及人造有机纳米孔道的设计方法。最后提出了水处理仿生膜所面临的挑战，展望了仿生膜发展的前景。

关键词： 细胞膜     水通道蛋白     仿生膜     碳纳米管     人造水通道    

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微小型机器鼠仿鼠行为学习与生成

高子航, 贾广禄, 谢宏钊, 黄强, 福田敏男, 石青

《工程（英文）》 2022年 第17卷 第10期   页码 232-243 doi: 10.1016/j.eng.2022.05.012

摘要：

现有的仿生机器鼠仅可以执行一些基本的仿鼠运动基元（MP），并通过这些基元的刚性组合来形成简单的行为。为了模拟具有高相似性的典型实验鼠行为，本文提出使用概率模型和运动特征对实验鼠的行为进行参数化。首先，对15 个10 min 的实验鼠运动视频片段的分析表明，一只实验鼠在野外通常有6 种典型的行为，且每种行为都包含8 个运动基元的不同组合。本文首先使用softmax 分类器来获得实验鼠的行为-运动分层概率模型。其次，使用静态和动态的运动参数对运动基元组合进行特征化。本文分别使用分层聚类和模糊C均值（FCM）聚类获得静态和动态运动参数的优势值。这些优势值通过二阶傅里叶级数对实验鼠的脊柱关节轨迹进行拟合，并且通过具有两个隐藏层的反向传播（BP）神经网络对关节轨迹进行泛化。最后，将分层概率模型和泛化的关节轨迹分别作为控制策略和指令映射到机器鼠。本文在机器鼠上实现了6 种典型的仿鼠行为，其结果与实验鼠的行为相比显示出高度相似性。

关键词： 仿生学     微小型机器鼠     神经网络学习     行为生成    

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Learning from biological attachment devices: applications of bioinspired reversible adhesive methods in robotics

《机械工程前沿（英文）》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0699-x

摘要： Many organisms have attachment organs with excellent functions, such as adhesion, clinging, and grasping, as a result of biological evolution to adapt to complex living environments. From nanoscale to macroscale, each type of adhesive organ has its own underlying mechanisms. Many biological adhesive mechanisms have been studied and can be incorporated into robot designs. This paper presents a systematic review of reversible biological adhesive methods and the bioinspired attachment devices that can be used in robotics. The study discussed how biological adhesive methods, such as dry adhesion, wet adhesion, mechanical adhesion, and sub-ambient pressure adhesion, progress in research. The morphology of typical adhesive organs, as well as the corresponding attachment models, is highlighted. The current state of bioinspired attachment device design and fabrication is discussed. Then, the design principles of attachment devices are summarized in this article. The following section provides a systematic overview of climbing robots with bioinspired attachment devices. Finally, the current challenges and opportunities in bioinspired attachment research in robotics are discussed.

关键词： adhesion     bioinspired attachment     biomimetic gripper     climbing robot    

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Immobilization of

Xiaokai SONG,Zhongyi JIANG,Lin LI,Hong WU

《化学科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 353-361 doi: 10.1007/s11705-014-1421-2

摘要： Mesoporous silica particles were prepared for efficient immobilization of the -glucuronidase (GUS) through a biomimetic mineralization process, in which the solution containing lysozyme and GUS were added into the prehydrolyzed tetraethoxysilane (TEOS) solution. The silica particles were formed in a way of biomineralization under the catalysis of lysozyme and GUS was immobilized into the silica particles simultaneously during the precipitation process. The average diameter of the silica particles is about 200 nm with a pore size of about 4 nm. All the enzyme molecules are tightly entrapped inside the biosilica nanoparticles without any leaching even under a high ionic strength condition. The immobilized GUS exhibits significantly higher thermal and pH stability as well as the storage and recycling stability compared with GUS in free form. No loss in the enzyme activity of the immobilized GUS was found after 30-day’s storage, and the initial activity could be well retained after 12 repeated cycles.

关键词： storage and recycling stability     silica nanoparticles     biocatalysis     biomimetic synthesis     β-glucuronidase encapsulation    

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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

《化学科学与工程前沿（英文）》 2017年 第11卷 第4期   页码 624-632 doi: 10.1007/s11705-017-1614-6

摘要： Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

关键词： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

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Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,

《工程（英文）》 doi: 10.1016/j.eng.2023.05.022

摘要： Infections with multidrug-resistant (MRD) Gram-negative bacteria, such as MRD Escherichia coli (E. coli), remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies. This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages, consisting of an intelligent controlling center (a living macrophage, MΦ) and a Fenton reaction catalyst (Fe3O4@poly(lactic-co-glycolic acid) (PLGA) nanoparticles) for killing MDR E. coli without harming normal cells. The MΦ–Fe3O4@PLGA particles (i.e., the intelligent catalysis particles) exhibit selective biocatalysis activity toward MDR E. coli by producing H2O2 and lipid droplets (LDs). This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis. The H2O2 further reacts with Fe3O4@PLGA to form highly toxic hydroxyl radicals (•OH), while the LDs contain antimicrobial peptides and can target MDR E. coli. The highly toxic •OH and antimicrobial peptides are shown to combat with MDR E. coli, such that the antibacterial efficiency of the MΦ–Fe3O4@PLGA particles against MDR E. coli is 99.29% ± 0.31% in vitro. More importantly, after several passages, the intelligent catalysis function of the MΦ–Fe3O4@PLGA particles is well maintained. Hence, the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.

关键词： Multidrug-resistant Escherichia coli     Macrophage–Fe3O4@PLGA particles     Biomimetic intelligent catalysis    

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仿生与生物启发膜的研究进展

彭冬冬,贺明睿,杨 昊,张 蓓,高博鑫,范 琳,丁 鹤,南延虎,潘福生,苏延磊,吴 洪,姜忠义

《中国工程科学》 2014年 第16卷 第12期   页码 102-112

摘要：

仿生与生物启发的思想和策略在众多基础与工程科学领域取得了重要进展。研究者们通过借鉴和模仿自然界中生物材料多样的组成、精巧的结构、温和的形成过程以及强大的功能，设计制备了多种高性能膜材料，并将其应用于水处理、气体分离、有机小分子液体混合物分离等领域，显示出良好的应用前景。仿生和生物启发膜主要是以细胞膜、荷叶和贻贝等为仿生原型，以生物矿化、生物黏合和自组装等为工具，以绿色、高效、节能为目标，在资源、能源高效利用和可持续发展等方面会发挥越来越大的作用，并逐步发展成为膜和膜过程领域的重要分支。本文将对仿生和生物启发膜的研究进展进行简要总结，重点介绍抗污染膜、杂化膜和复合膜的制备与应用。

关键词： 仿生与生物启发膜     膜和膜过程     表面偏析     仿生矿化     仿生黏合    

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Design and simulation of a cable-pulley-based transmission for artificial ankle joints

Huaxin LIU,Marco CECCARELLI,Qiang HUANG

《机械工程前沿（英文）》 2016年 第11卷 第2期   页码 170-183 doi: 10.1007/s11465-016-0383-0

摘要：

In this paper, a mechanical transmission based on cable pulley is proposed for human-like actuation in the artificial ankle joints of human-scale. The anatomy articular characteristics of the human ankle is discussed for proper biomimetic inspiration in designing an accurate, efficient, and robust motion control of artificial ankle joint devices. The design procedure is presented through the inclusion of conceptual considerations and design details for an interactive solution of the transmission system. A mechanical design is elaborated for the ankle joint angular with pitch motion. A multi-body dynamic simulation model is elaborated accordingly and evaluated numerically in the ADAMS environment. Results of the numerical simulations are discussed to evaluate the dynamic performance of the proposed design solution and to investigate the feasibility of the proposed design in future applications for humanoid robots.

关键词： biomimetic designs     ankle joints     cable-pulley transmissions     multi-body dynamic simulation     numerical characterization    

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Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

Yakai FENG, Haiyang ZHAO, Li ZHANG, Jintang GUO,

《化学科学与工程前沿（英文）》 2010年 第4卷 第3期   页码 372-381 doi: 10.1007/s11705-010-0005-z

摘要： Thrombus formation and blood coagulation are serious problems associated with blood contacting products, such as catheters, vascular grafts, artificial hearts, and heart valves. Recent progresses and strategies to improve the hemocompatibility of biomaterials by surface modification using photochemical immobilization and photograft polymerization are reviewed in this paper. Three approaches to modify biomaterial surfaces for improving the hemocompatibility, i.e., bioinert surfaces, immobilization of anticoagulative substances and biomimetic surfaces, are introduced. The biomimetic amphiphilic phosphorylcholine and Arg-Gly-Asp (RGD) sequence are the most effective and most often employed biomolecules and peptide sequence for improving hemocompatibility of material surfaces. The RGD sequence can enhance adhesion and growth of endothelial cells (ECs) on material surfaces and increase the retention of ECs under flow shear stress conditions. This surface modification is a promising strategy for biomaterials especially for cardiovascular grafts and functional tissue engineered blood vessels.

关键词： biomimetic amphiphilic     amphiphilic phosphorylcholine     endothelial     functional     biomaterial    

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标题 作者 时间 类型 操作

Selective oxidation of o -nitrotoluene to o -nitrobenzaldehyde with metalloporphyrins as biomimetic catalysts

Xinling WANG, Yuanbin SHE,

期刊论文

Bioinspired and biomimetic membranes for water purification and chemical separation: A review

期刊论文

Preparation, with graphene, of novel biomimetic self-healing microcapsules with high thermal stability

期刊论文

Biomimetic mineralization and cytocompatibility of nanorod hydroxyapatite/graphene oxide composites

Peizhen Duan, Juan Shen, Guohong Zou, Xu Xia, Bo Jin

期刊论文

生物材料的仿生构思

姚康德,沈峰

期刊论文

Roles of glutathione and L-cysteine in the biomimetic green synthesis of CdSe quantum dots

Ling-Li Li, Yin-Hua Cui, Jie-Jie Chen, Han-Qing Yu

期刊论文

水处理仿生膜研究进展

曾艳军,张林,陈欢林

期刊论文

微小型机器鼠仿鼠行为学习与生成

高子航, 贾广禄, 谢宏钊, 黄强, 福田敏男, 石青

期刊论文

Learning from biological attachment devices: applications of bioinspired reversible adhesive methods in robotics

期刊论文

Immobilization of

Xiaokai SONG,Zhongyi JIANG,Lin LI,Hong WU

期刊论文

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

期刊论文

Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,

期刊论文

仿生与生物启发膜的研究进展

彭冬冬,贺明睿,杨 昊,张 蓓,高博鑫,范 琳,丁 鹤,南延虎,潘福生,苏延磊,吴 洪,姜忠义

期刊论文

Design and simulation of a cable-pulley-based transmission for artificial ankle joints

Huaxin LIU,Marco CECCARELLI,Qiang HUANG

期刊论文

Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

Yakai FENG, Haiyang ZHAO, Li ZHANG, Jintang GUO,

期刊论文