检索范围:
排序: 展示方式:
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and
《医学前沿(英文)》 2023年 第17卷 第1期 页码 132-142 doi: 10.1007/s11684-022-0938-x
The impact of hypoxia in hepatocellular carcinoma metastasis
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 33-41 doi: 10.1007/s11684-013-0301-3
Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondar y growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.
关键词: hypoxia hepatocellular carcinoma (HCC) metastasis hypoxia-inducible factor (HIF)
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.
关键词: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic polymorphism
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 509-521 doi: 10.1007/s11684-017-0546-3
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell-based therapies could dominate important roles in the future immunotherapeutic market of HCC.
关键词: natural killer cell hepatocellular carcinoma immunotherapy
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 191-202 doi: 10.1007/s11684-017-0512-0
Primary hepatic carcinoma (PHC) is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine (TCM). TCM has been widely used to improve the quality of life, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials (RCTs) involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.
关键词: traditional Chinese medicine primary hepatic carcinoma meta-analysis
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 183-190 doi: 10.1007/s11684-016-0440-4
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.
关键词: hepatocellular carcinoma coexpression module microarray prognosis
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
《医学前沿(英文)》 2020年 第14卷 第3期 页码 273-283 doi: 10.1007/s11684-019-0728-2
关键词: hepatocellular carcinoma tyrosine kinase inhibitor check point inhibitor anti-angiogenesis
A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 112-116 doi: 10.1007/s11684-014-0345-z
Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response based on RECIST criteria) and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.d literature were discussed.
Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder
Bin HAO, Changwei LIU, Huixiang LI
《医学前沿(英文)》 2009年 第3卷 第2期 页码 197-203 doi: 10.1007/s11684-009-0036-3
关键词: transitional cell carcinoma of bladder phosphatase of regenerating liver 1 phosphatase of regenerating liver 3 reverse transcription polymerase chain reaction immunohistochemistry
Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells
XIONG Ying, GUO Wen, LI Ting, LI Ke
《医学前沿(英文)》 2007年 第1卷 第3期 页码 304-307 doi: 10.1007/s11684-007-0058-7
关键词: control therapy influence Survivin-1 colorectal carcinoma
Jianpeng Liu, Xinhua Chen, Shusen Zheng
《医学前沿(英文)》 2021年 第15卷 第2期 页码 170-177 doi: 10.1007/s11684-020-0747-z
关键词: nanosecond pulsed electric fields (nsPEF) hepatocellular carcinoma (HCC) immune response recurrence metastasis
Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 113-117 doi: 10.1007/s11684-014-0310-x
Papillary thyroid carcinoma (PTC) is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained (C vs. T, P=0.027, OR=1.264, 95% CI=1.026-1.557; and C/C-C/T vs. T/T, P=0.034, OR=1.474, 95% CI=1.028-2.112). Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 (adjusted P=0.062) between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction (P=0.029; OR=2.578, 95% CI=1.104-6.023) between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.
关键词:
Small cell carcinoma of the urinary bladder without gross hematuria: a case report
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 384-387 doi: 10.1007/s11684-015-0405-z
Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.
关键词: carcinoma small cell urinary bladder neoplasms diagnosis
《医学前沿(英文)》 2023年 第17卷 第4期 页码 729-746 doi: 10.1007/s11684-022-0978-2
关键词: hepatocellular carcinoma YAP1 Akkermansia muciniphila anti-PD-1 dihydroartemisinin bile acid
Junfang JI, Kun WU, Min WU, Qimin ZHAN,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 412-418 doi: 10.1007/s11684-010-0260-x
标题 作者 时间 类型 操作
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
期刊论文
Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic
null
期刊论文
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
null
期刊论文
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
期刊论文
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
期刊论文
A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy
null
期刊论文
Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder
Bin HAO, Changwei LIU, Huixiang LI
期刊论文
Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells
XIONG Ying, GUO Wen, LI Ting, LI Ke
期刊论文
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric
Jianpeng Liu, Xinhua Chen, Shusen Zheng
期刊论文
Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern
null
期刊论文
Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma
期刊论文