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Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI
《结构与土木工程前沿(英文)》 2014年 第8卷 第4期 页码 448-455 doi: 10.1007/s11709-014-0262-x
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 229-235 doi: 10.1007/s11684-017-0581-0
On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.
关键词: molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H
An approach for mechanical fault classification based on generalized discriminant analysis
LI Wei-hua, SHI Tie-lin, YANG Shu-zi
《机械工程前沿(英文)》 2006年 第1卷 第3期 页码 292-298 doi: 10.1007/s11465-006-0022-2
关键词: generalized discriminant non-separable abnormality classification multi-faults classification
EAI-oriented information classification code system in manufacturing enterprises
WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing
《机械工程前沿(英文)》 2008年 第3卷 第1期 页码 81-85 doi: 10.1007/s11465-008-0011-8
K. Sathish KUMAR, T. JAYABARATHI
《能源前沿(英文)》 2012年 第6卷 第4期 页码 394-402 doi: 10.1007/s11708-012-0211-0
关键词: support vector machines (SVM) structural risk minimization (SRM) equivalent capacity margin (ECM) restoration fault classification
Progress on molecular biomarkers and classification of malignant gliomas
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 150-156 doi: 10.1007/s11684-013-0267-1
Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
关键词: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Multiclass classification based on a deep convolutional
Ying CAI,Meng-long YANG,Jun LI
《信息与电子工程前沿(英文)》 2015年 第16卷 第11期 页码 930-939 doi: 10.1631/FITEE.1500125
关键词: Head pose estimation Deep convolutional neural network Multiclass classification
Xinjun LIU, Xiang CHEN, Zhidong LI
《机械工程前沿(英文)》 2012年 第7卷 第2期 页码 199-209 doi: 10.1007/s11465-012-0315-6
Due to the demand of reconfigurable system in parallel kinematic machines (PKMs), modular design technology is significant and necessary. However, in earlier research, the core joint modules have been concerned about rather than the customized link modules. The modular design to the typical customized links from the point of seeking optimal structures with best mechanical performances is analyzed and processed in two steps: classification and optimization. Firstly, a brief introduction to the current research status and the aims of this paper are outlined. And then, how the typical customized links classified is proposed. Next, the technology method and the iterative formula derivation process of topology optimization are described in detail. Finally, calculation models for each group of classified ones are set up and their optimal structures are achieved through topology optimization technique. The results provide useful references for reconfigurable and modular design in engineering cases.
关键词: parallel kinematic machines (PKMs) modular design classification topology optimization and improved Guide-Weight method
Arthrogryposis multiplex congenita: classification, diagnosis, perioperative care, and anesthesia
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 48-52 doi: 10.1007/s11684-017-0500-4
Arthrogryposis multiplex congenita (AMC) is a rare disorder characterized by non-progressive, multiple contractures. In addition to affected extremities, patients may also present microstomia, decreased temporomandibular joint mobility. Although the etiology of AMC is unclear, any factor that decreases fetal movement is responsible for AMC. Thus, accurate diagnosis and classification are crucial to the appropriate treatment of AMC. The development of ultrasound technology has enabled prenatal diagnosis. Very early treatment is favorable, and multidisciplinary treatment is necessary to improve the function of AMC patients. Most patients require surgery to release contracture and reconstruct joints. However, perioperative care is challenging, and difficult airway is the first concern of anesthesiologists. Postoperative pulmonary complications are common and regional anesthesia is recommended for postoperative analgesia. This review on AMC is intended for anesthesiologists. Thus, we discuss the treatment and perioperative management of patients undergoing surgery, as well as the diagnosis and classification of AMC.
关键词: arthrogryposis amyoplasia distal arthrogryposis anesthesia
Molecular classification and molecular targeted therapy of cancer
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 147-149 doi: 10.1007/s11684-013-0274-2
Fine-grained P2P traffic classification by simply counting flows
Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG
《信息与电子工程前沿(英文)》 2015年 第16卷 第5期 页码 391-403 doi: 10.1631/FITEE.1400267
关键词: Traffic classification Peer-to-peer (P2P) Fine-grained Host-based
Terrain classification and adaptive locomotion for a hexapod robot Qingzhui
Yue ZHAO, Feng GAO, Qiao SUN, Yunpeng YIN
《机械工程前沿(英文)》 2021年 第16卷 第2期 页码 271-284 doi: 10.1007/s11465-020-0623-1
关键词: terrain classification hexapod robot legged robot adaptive locomotion gait control
《结构与土木工程前沿(英文)》 2022年 第16卷 第2期 页码 202-213 doi: 10.1007/s11709-021-0795-8
关键词: excavated soil construction sludge geotechnical and underground engineering production classification
Present situation and classification of piezoelectric pump
Fang YE, Shouyin WANG, Wei CHENG, Qixiao XIA, Jianhui ZHANG,
《机械工程前沿(英文)》 2009年 第4卷 第4期 页码 420-429 doi: 10.1007/s11465-009-0052-7
关键词: piezoelectric pump development and present situation new classification method valveless piezoelectric pump new forms of piezoelectric pump
Jiaquan ZHANG, Shihua QI, Xinli XING, Lingzhi TAN, Wei CHEN, Ying HU, Dan YANG, Chenxi WU
《环境科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 177-183 doi: 10.1007/s11783-011-0354-y
关键词: Jiulong River hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethan (DDT) classification Hierarchical Cluster Analysis (HCA) Pearson’s bivariate Correlations Analysis (PCA)
标题 作者 时间 类型 操作
Development of a new method for RMR and Q classification method to optimize support system in tunneling
Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI
期刊论文
An approach for mechanical fault classification based on generalized discriminant analysis
LI Wei-hua, SHI Tie-lin, YANG Shu-zi
期刊论文
EAI-oriented information classification code system in manufacturing enterprises
WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing
期刊论文
Fault classification and reconfiguration of distribution systems using equivalent capacity margin method
K. Sathish KUMAR, T. JAYABARATHI
期刊论文
Modular design of typical rigid links in parallel kinematic machines: Classification and topology optimization
Xinjun LIU, Xiang CHEN, Zhidong LI
期刊论文
Arthrogryposis multiplex congenita: classification, diagnosis, perioperative care, and anesthesia
null
期刊论文
Fine-grained P2P traffic classification by simply counting flows
Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG
期刊论文
Terrain classification and adaptive locomotion for a hexapod robot Qingzhui
Yue ZHAO, Feng GAO, Qiao SUN, Yunpeng YIN
期刊论文
Classification and quantification of excavated soil and construction sludge: A case study in Wenzhou,
期刊论文
Present situation and classification of piezoelectric pump
Fang YE, Shouyin WANG, Wei CHENG, Qixiao XIA, Jianhui ZHANG,
期刊论文