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New method for efficient control of hydrogen sulfide and methane in gravity sewers: Combination of NaOH

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1509-0

摘要：

• The combination of NaOH and nitrite was used to control harmful gas in sewers.

关键词： Sewer corrosion     Sulfide control     Combination treatment     NaOH     Nitrite    

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Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

《医学前沿（英文）》 2019年 第13卷 第1期   页码 12-23 doi: 10.1007/s11684-019-0685-9

摘要：

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients’ outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.

关键词： gastrointestinal cancer     immune checkpoint inhibitor     combination therapy    

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Removal of virus aerosols by the combination of filtration and UV-C irradiation

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1627-y

摘要：

● The removal of virus aerosols by filtration and UV-C irradiation was proposed.

关键词： Filtration system     UV-C irradiation     Virus aerosol     Public health     COVID-19    

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基于评价方法属性层次的组合评价研究

陈衍泰,陈国宏,李美娟

《中国工程科学》 2005年 第7卷 第8期   页码 56-59

摘要：

针对现存的多种单一综合评价方法机理、属性层次相异引起的对同一个对象评价结论不相容的问题，提出一种新的组合评价方法。定义了“具有相容性”与“特殊属性”的两类综合评价方法；建立了两个组合评价模型，分别将这两个属性层次方法所得的不一致的评价值与排序结论进行组合；在此基础上提出“复组合”的概念。并应用此模型对我国欠发达地区15个城市的综合实力进行评价，使得系统评价更具有科学性和实用性，为欠发达地区开发战略制订宏观经济政策提供实证基础。

关键词： 评价方法的属性层次     组合模型     复组合    

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Adsorption in combination with ozonation for the treatment of textile waste water: a critical review

Shraddha Khamparia,Dipika Kaur Jaspal

《环境科学与工程前沿（英文）》 2017年 第11卷 第1期 doi: 10.1007/s11783-017-0899-5

摘要： A combination of adsorption with ozonation proved best for dye removal. Toxicity of the textile effluents can be remarkably reduced by combined method. Wide scope for choice of natural materials for treatment of textile dyes. Intrusion of synthetic textile dyes in the ecosystem has been recognized as a serious issue worldwide. The effluents generated from textiles contain large amount of recalcitrant unfixed dyes which are regarded as emerging contaminants in the field of waste water study. Removal of various toxic dyes often includes diverse and complex set of physico-chemical, biological and advanced oxidation processes adopted for treatment. Adsorption in itself is a well-known technique utilized for treatment of textile effluents using a variety of adsorbents. In addition, ozonation deals with effective removal of dyes using high oxidising power of ozone. The review summarizes dye removal study by a combination of ozonation and adsorption methods. Also, to acquire an effective interpretation of this combined approach of treating wastewater, a thorough study has been made which is deliberated here. Results asserts that, with the combined ability of ozone and a catalyst/adsorbent, there is high possibility of total elimination of dyes from waste water. Several synthetically prepared materials have been used along with few natural materials during the combined treatment. However, considering practical applicability, some areas were identified during the study where work needs to be done for effective implementation of the combined treatment.

关键词： Adsorption     Ozonation     Catalytic Ozonation     Textile dyes     Mineralization    

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Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions

《化学科学与工程前沿（英文）》 2023年 第17卷 第12期   页码 2144-2155 doi: 10.1007/s11705-023-2362-4

摘要： This study introduces multifunctional silica nanoparticles that exhibit both high photothermal and chemodynamic therapeutic activities, in addition to luminescence. The activity of the silica nanoparticles is derived from their plasmonic properties, which are a result of infusing the silica nanoparticles with multiple Cu2–xS cores. This infusion process is facilitated by a recoating of the silica nanoparticles with a cationic surfactant. The key factors that enable the internal incorporation of the Cu2–xS cores and the external deposition of red-emitting carbon dots are identified. The Cu2–xS cores within the silica nanoparticles exhibit both self-boosting generation of reactive oxygen species and high photothermal conversion efficacy, which are essential for photothermal and chemodynamic activities. The silica nanoparticles’ small size (no more than 70 nm) and high colloidal stability are prerequisites for their cell internalization. The internalization of the red-emitting silica nanoparticles within cells is visualized using fluorescence microscopy techniques. The chemodynamic activity of the silica nanoparticles is associated with their dark cytotoxicity, and the mechanisms of cell death are evaluated using an apoptotic assay. The photothermal activity of the silica nanoparticles is demonstrated by significant cell death under near-infrared (1064 nm) irradiation.

关键词： copper sulfide nanoparticles     chemodynamic therapy     photothermal therapy     carbon dots     silica nanoparticles    

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Enhanced bioethanol production from sugarcane bagasse: combination of liquid hot water and deep eutectic

《化学科学与工程前沿（英文）》 2024年 第18卷 第8期 doi: 10.1007/s11705-024-2438-9

摘要： In the present study, a sustainable pretreatment methodology combining liquid hot water and deep eutectic solvent is proposed for the efficient fractionation of hemicellulose, cellulose, and lignin from sugarcane bagasse, thereby facilitating the comprehensive utilization of both C5 and C6 sugars. The application of this combined pretreatment strategy to sugarcane bagasse led to notable enhancements in enzymatic saccharification and subsequent fermentation. Experiment results demonstrate that liquid hot water-deep eutectic solvent pretreatment yielded 85.05 ± 0.66 g·L–1 of total fermentable sugar (glucose: 60.96 ± 0.21 g·L–1, xylose: 24.09 ± 0.87 g·L–1) through enzymatic saccharification of sugarcane bagasse. Furthermore, fermentation of the pretreated sugarcane bagasse hydrolysate yielded 34.33 ± 3.15 g·L–1 of bioethanol. These findings confirm the effectiveness of liquid hot water-deep eutectic solvent pretreatment in separating lignocellulosic components, thus presenting a sustainable and promising pretreatment method for maximizing the valuable utilization of biomass resources.

关键词： sugar cane bagasse     synergistic pretreatment     enzymatic saccharification     ethanol    

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Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

《医学前沿（英文）》 2009年 第3卷 第1期   页码 108-112 doi: 10.1007/s11684-009-0015-8

摘要： This study aimed to investigate the effects of celecoxib, synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437) and the combination of the two on cell proliferation, apoptosis, and cycle arrest of human malignant melanoma A375 cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyltetrazoliumbromide assay (MTT assay) was applied to determine the anti-proliferative effects of the drugs on human malignant melanoma A375 cells. Flow cytometry was performed to investigate the influence of the drugs on cell cycle and cell apoptosis. Both celecoxib and CD437 could inhibit the growth of human malignant melanoma A375 cells in a dose-dependent manner. Celecoxib at 80 μmol/L inhibited proliferation, induced apoptosis and G /M cell cycle arrest of human malignant melanoma A375 cells after treatment for 24 h [proliferation inhibiting rate: (50.2±2.51)%, apoptosis rate: (35.91±1.80)%]. CD437 at 10 μmol/L inhibited proliferation, induced apoptosis and G /G cell cycle arrest of human malignant melanoma A375 cells after treatment for 24 h [proliferation inhibiting rate: (58.6±2.38)%, apoptosis rate: (28.03±0.77)%]. Celecoxib in combination with CD437 could significantly enhance the effects of inhibiting proliferation and inducing apoptosis of human malignant melanoma A375 cells 24 h after treatment compared with the drug alone [proliferation inhibiting rate: (68.92±1.72)%, apoptosis rate: (42.09±1.05)%, both <0.05] and could decrease the proportion of the S phase in the cell cycle. Celecoxib could inhibit the growth of human malignant melanoma A375 cells by inducing apoptosis and G /M cycle arrest. CD437 could inhibit the growth of human malignant melanoma A375 cells by inducing apoptosis and G /G cycle arrest. Celecoxib exhibited additive effects with CD437 on retarding the growth and inducing apoptosis of human malignant melanoma A375 cells. Celecoxib in combination with CD437 may become an effective method for prevention and treatment of human melanoma.

关键词： celecoxib     CD437     melanoma A375 cell     apoptosis     cycle arrest    

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approach of low carbon and efficient utilization of coal resources: The polygeneration system of a combination

Kechang XIE, Fan LI

《化学科学与工程前沿（英文）》 2010年 第4卷 第4期   页码 383-384 doi: 10.1007/s11705-010-0526-5

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Combination form analysis and experimental study of mechanical properties on steel sheet glass fiber

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 834-850 doi: 10.1007/s11709-021-0743-7

摘要： The concept of steel sheet glass fiber reinforced polymer (GFRP) composite bar (SSGCB) was put forward. An optimization plan was proposed in the combined form of SSGCB. The composite principle, material selection, and SSGCB preparation technology have been described in detail. Three-dimensional finite element analysis was adopted to perform the combination form optimization of different steel core structures and different steel core contents based on the mechanical properties. Mechanical tests such as uniaxial tensile, shear, and compressive tests were carried out on SSGCB. Parametric analysis was conducted to investigate the influence of steel content on the mechanical properties of SSGCB. The results revealed that the elastic modulus of SSGCB had improvements and increased with the rise of steel content. Shear strength was also increased with the addition of steel content. Furthermore, the yield state of SSGCB was similar to the steel bar, both of which indicated a multi-stage yield phenomenon. The compressive strength of SSGCB was lower than that of GFRP bars and increased with the increase of the steel core content. Stress-strain curves of SSGCB demonstrated that the nonlinear-stage characteristics of SSGCB-8 were much more obvious than other bars.

关键词： steel sheet GFRP composite bar     combination form     numerical modeling     mechanical properties test     strength    

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The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from

Sheng-Xuan LIU, Zhi-Hua HUANG

《医学前沿（英文）》 2010年 第4卷 第3期   页码 342-345 doi: 10.1007/s11684-010-0099-1

摘要： The aim of this study was to investigate the value of technetium etifenin injection ( Tc-EHIDA) hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia. Tc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile jaundice. For diagnosing biliary atresia, the sensitivity and specificity of scintigraphy were 100% and 74.5%, respectively; the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%, respectively. In conclusion, hepatobiliary scintigraphy, which is a noninvasive, safe, valuable examination method, in combination with examination of duodenal fluid, is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.

关键词： jaundice     radionuclide hepatobiliary scintigraphy     duodenal drainage    

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Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous

《医学前沿（英文）》 2022年 第16卷 第4期   页码 610-617 doi: 10.1007/s11684-021-0827-8

摘要： Bevacizumab, an anti-VEGF monoclonal antibody, has significantly improved the clinical outcomes of patients with advanced non-squamous NSCLC (ns-NSCLC). However, the safety and efficacy of bevacizumab for elderly patients with advanced NSCLC require further investigation. Thus, 59 patients were included in the present retrospective study, 22 patients in the bevacizumab plus pemetrexed and platinum (B+PP) group, and 37 patients in the pemetrexed and platinum (PP) group. For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survival rates were 88.5% and 67.8%, respectively. The median OS and 1-year and 2-year OS rates were 20.5 months, 70.3% and 0%, respectively, in the B+PP group and 33.4 months, 97.0% and 89.4%, respectively, in the PP group (P <0.001). The incidence of grade≥3 adverse events was higher in the B+PP group than in the PP group (27.3% vs. 10.8%, respectively; P=0.204). Univariate and multivariate analyses suggested that the receipt of≥5 cycles of first-line chemotherapy was an independent favorable prognostic factor for OS, whereas the addition of bevacizumab was an unfavorable prognostic factor. With increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of elderly patients with advanced ns-NSCLC.

关键词： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

《医学前沿（英文）》 2023年 第17卷 第2期   页码 275-289 doi: 10.1007/s11684-022-0945-y

摘要： The abnormal activation of HER family kinase activity is closely related to the development of human malignancies. In this study, we used HER kinases as targets for the treatment of nasopharyngeal carcinoma (NPC) and explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B, alone or in combination with cisplatin. We found that HER family proteins were positively expressed in tumor tissues of some NPC patients, and the high levels of those proteins were significantly related to poor prognosis. HM781-36B inhibited NPC in vitro and in vivo. HM781-36B exerted synergistic effects with cisplatin on inhibiting proliferation and promoting apoptosis of NPC cells. In NPC xenograft models in nude mice, HM781-36B and cisplatin synergistically inhibited tumor growth. Downregulating the activity of HER family proteins and their downstream signaling pathways and regulating tumor microenvironment may explain the synergistic anti-tumor effects of HM781-36B and cisplatin. In conclusion, our study provides evidence for HER family proteins as prognostic biomarkers and potential therapeutic targets for NPC. The pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic effects for the treatment of NPC patients, which provides a new idea for the comprehensive treatment of NPC.

关键词： epidermal growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted therapy     cisplatin    

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Level set band method: A combination of density-based and level set methods for the topology optimization

Peng WEI, Wenwen WANG, Yang YANG, Michael Yu WANG

《机械工程前沿（英文）》 2020年 第15卷 第3期   页码 390-405 doi: 10.1007/s11465-020-0588-0

摘要： The level set method (LSM), which is transplanted from the computer graphics field, has been successfully introduced into the structural topology optimization field for about two decades, but it still has not been widely applied to practical engineering problems as density-based methods do. One of the reasons is that it acts as a boundary evolution algorithm, which is not as flexible as density-based methods at controlling topology changes. In this study, a level set band method is proposed to overcome this drawback in handling topology changes in the level set framework. This scheme is proposed to improve the continuity of objective and constraint functions by incorporating one parameter, namely, level set band, to seamlessly combine LSM and density-based method to utilize their advantages. The proposed method demonstrates a flexible topology change by applying a certain size of the level set band and can converge to a clear boundary representation methodology. The method is easy to implement for improving existing LSMs and does not require the introduction of penalization or filtering factors that are prone to numerical issues. Several 2D and 3D numerical examples of compliance minimization problems are studied to illustrate the effects of the proposed method.

关键词： level set method     topology optimization     density-based method     level set band    

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基于BP-AGA的非线性组合预测方法研究

王硕,张有富,金菊良

《中国工程科学》 2005年 第7卷 第4期   页码 83-87

摘要：

运用神经网络和加速遗传算法建立非线性组合预测模型，在BP算法训练网络出现收敛速度缓慢时启用加速遗传算法（AGA）来优化网络参数，把AGA的优化结果作为BP算法的初始值，再用BP算法训练网络，如此交替运行BP算法和AGA以加快网络的收敛速度，同时改善局部最小问题。最后给出实例研究，结果表明，该方法能明显提高预测精度。

关键词： 神经网络     加速遗传算法     非线性组合预测     预测精度    

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标题 作者 时间 类型 操作

New method for efficient control of hydrogen sulfide and methane in gravity sewers: Combination of NaOH

期刊论文

Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

期刊论文

Removal of virus aerosols by the combination of filtration and UV-C irradiation

期刊论文

基于评价方法属性层次的组合评价研究

陈衍泰,陈国宏,李美娟

期刊论文

Adsorption in combination with ozonation for the treatment of textile waste water: a critical review

Shraddha Khamparia,Dipika Kaur Jaspal

期刊论文

Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions

期刊论文

Enhanced bioethanol production from sugarcane bagasse: combination of liquid hot water and deep eutectic

期刊论文

Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

期刊论文

approach of low carbon and efficient utilization of coal resources: The polygeneration system of a combination

Kechang XIE, Fan LI

期刊论文

Combination form analysis and experimental study of mechanical properties on steel sheet glass fiber

期刊论文

The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from

Sheng-Xuan LIU, Zhi-Hua HUANG

期刊论文

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous

期刊论文

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

期刊论文

Level set band method: A combination of density-based and level set methods for the topology optimization

Peng WEI, Wenwen WANG, Yang YANG, Michael Yu WANG

期刊论文

基于BP-AGA的非线性组合预测方法研究

王硕,张有富,金菊良

期刊论文