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Strain and process engineering toward continuous industrial fermentation

《化学科学与工程前沿（英文）》 2023年 第17卷 第10期   页码 1336-1353 doi: 10.1007/s11705-022-2284-6

摘要： Most current biotechnology industries are based on batch or fed-batch fermentation processes, which often show low productivity and high production costs compared to chemical processes. To increase the economic competitiveness of biological processes, continuous fermentation technologies are being developed that offer significant advantages in comparison with batch/fed-batch fermentation processes, including: (1) removal of potential substrates and product inhibition, (2) prolonging the microbial exponential growth phase and enhancing productivity, and (3) avoiding repeated fermentation preparation and lowering operation and installation costs. However, several key challenges should be addressed for the industrial application of continuous fermentation processes, including (1) contamination of the fermentation system, (2) degeneration of strains, and (3) relatively low product titer. In this study, we reviewed and discussed metabolic engineering and synthetic biology strategies to address these issues.

关键词： continuous fermentation     productivity     contamination     strain degeneration     metabolic engineering    

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Ant colony optimization in continuous problem

YU Ling, LIU Kang, LI Kaishi

《机械工程前沿（英文）》 2007年 第2卷 第4期   页码 459-462 doi: 10.1007/s11465-007-0079-6

摘要： Based on the analysis of the basic ant colony optimization and optimum problem in a continuous space, an ant colony optimization (ACO) for continuous problem is constructed and discussed. The algorithm is efficient and beneficial to the study of the ant colony optimization in a continuous space.

关键词： beneficial     algorithm     efficient     continuous     ACO    

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连续铸钢前沿技术的工程化

干勇

《中国工程科学》 2002年 第4卷 第9期   页码 12-18

摘要：

论述了具有我国自主知识产权的高效连铸和薄板坯连铸工程化关键技术的特点；介绍了连续铸钢领域轻压下、液压非正弦振动、电磁连铸等前沿技术的开发现状；阐述了传统连铸技术超高效率、高品质化及近终形连铸、电磁连铸开发的研发方向。

关键词： 连续铸钢     高效连铸     薄板坯连铸     轻压下     电磁连铸    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

《化学科学与工程前沿（英文）》 2023年 第17卷 第12期   页码 1866-1878 doi: 10.1007/s11705-023-2340-x

摘要： Continuous glucose monitoring (CGM) systems play an increasingly vital role in the glycemic control of patients with diabetes mellitus. However, the immune responses triggered by the implantation of poorly biocompatible sensors have a significant impact on the accuracy and lifetime of CGM systems. In this review, research efforts over the past few years to mitigate the immune responses by enhancing the anti-biofouling ability of sensors are summarized. This review divided these works into active immune engaging strategy and passive immune escape strategy based on their respective mechanisms. In each strategy, the various biocompatible layers on the biosensor surface, such as drug-releasing membranes, hydrogels, hydrophilic membranes, anti-biofouling membranes based on zwitterionic polymers, and bio-mimicking membranes, are described in detail. This review, therefore, provides researchers working on implantable biosensors for CGM systems with vital information, which is likely to aid in the research and development of novel CGM systems with profound anti-biofouling properties.

关键词： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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Bending and rotational behaviour of semi-continuous composite beams

WANG Jingfeng, LI Guoqiang

《结构与土木工程前沿（英文）》 2008年 第2卷 第2期   页码 116-122 doi: 10.1007/s11709-008-0015-9

摘要： Stresses and deflections were measured in various semi-continuous composite beams. The bending and rotational capacities of the composite connections were measured in terms of beam curvatures and deflections by using two full-scale semi-rigid composite frames with monotonic loadings. The effect of semi-rigid connections on the performance of composite beams with various loadings was compared with predictions and codes. The tests show that the semi-continuous composite beams are more economic and effective than the simple or continuous composite beams. The semi-rigid connections affect the bending capacities and beam deflections, so the connection behavior should be considered in the design of composite beams. Yielding analysis of the steel beam bottom flange has some influence on the deflection calculation of composite beams.

关键词： rotational     effective     deflection calculation     semi-continuous composite     full-scale semi-rigid    

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Seismic performance of fabricated continuous girder bridge with grouting sleeve-prestressed tendon composite

《结构与土木工程前沿（英文）》   页码 827-854 doi: 10.1007/s11709-023-0954-1

摘要： The seismic performance of a fully fabricated bridge is a key factor limiting its application. In this study, a fiber element model of a fabricated concrete pier with grouting sleeve-prestressed tendon composite connections was built and verified. A numerical analysis of three types of continuous girder bridges was conducted with different piers: a cast-in-place reinforced concrete pier, a grouting sleeve-fabricated pier, and a grouting sleeve-prestressed tendon composite fabricated pier. Furthermore, the seismic performance of the composite fabricated pier was investigated. The results show that the OpenSees fiber element model can successfully simulate the hysteresis behavior and failure mode of the grouted sleeve-fabricated pier. Under traditional non-near-fault ground motions, the pier top displacements of the grouting sleeve-fabricated pier and the composite fabricated pier were less than those of the cast-in-place reinforced concrete pier. The composite fabricated pier had a good self-centering capability. In addition, the plastic hinge zones of the grouting sleeve-fabricated pier and the composite fabricated pier shifted to the joint seam and upper edge of the grouting sleeve, respectively. The composite fabricated pier with optimal design parameters has good seismic performance and can be applied in high-intensity seismic areas; however, the influence of pile-soil interaction on its seismic performance should not be ignored.

关键词： seismic performance     continuous girder bridge     grouting sleeve-prestressed tendon composite connections     grouted sleeve connection     design parameters    

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Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated

《医学前沿（英文）》 2023年 第17卷 第1期   页码 68-74 doi: 10.1007/s11684-022-0955-9

摘要： Most information used to evaluate diabetic statuses is collected at a special time-point, such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk. As a new parameter for continuously evaluating personal clinical statuses, the newly developed technique “continuous glucose monitoring” (CGM) can characterize glucose dynamics. By calculating the complexity of glucose time series index (CGI) with refined composite multi-scale entropy analysis of the CGM data, the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes (P for trend < 0.01). Furthermore, CGI was significantly associated with various parameters such as insulin sensitivity/secretion (all P < 0.01), and multiple linear stepwise regression showed that the disposition index, which reflects β-cell function after adjusting for insulin sensitivity, was the only independent factor correlated with CGI (P < 0.01). Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis.

关键词： complexity of glucose time series     continuous glucose monitoring     impaired glucose regulation     insulin secretion and sensitivity     refined composite multi-scale entropy    

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Analysis of load transfer stability control strategy in hydraulic synchronized continuous slippage

LIU Yan-bo, WU Jian-zhong, ZHANG Xuan

《机械工程前沿（英文）》 2006年 第1卷 第2期   页码 222-226 doi: 10.1007/s11465-006-0007-1

摘要： Hydraulic synchronized continuous slippage technique, which integrates mechanical, electrical and hydraulic control, is introduced in this paper for the practical requirements of some construction projects. The core of this technique (the stability of the load transfer) is illustrated in detail. Three speed control strategies to transfer the load excessive, lower and same speed are presented to accomplish the smoothness and stability in the process of slippage. An optimization of the speed control strategy (same speed) is deduced from the modeling analysis and its validity and maneuverability are tested by practical application, which provides evidence for similar engineering in theory and practice.

关键词： excessive     slippage technique     optimization     continuous slippage     engineering    

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Non-invasive continuous blood pressure monitoring: a review of current applications

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 91-101 doi: 10.1007/s11684-013-0239-5

摘要：

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

关键词： non-invasive blood pressure monitoring     continuous blood pressure monitoring     invasive blood pressure monitoring     Riva-Rocci technique     oscillometric     Pe?áz technique     arterial tonometry     pulse transit time    

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Removal of dyes from wastewater by growing fungal pellets in a semi-continuous mode

Tao Lu, Qilei Zhang, Shanjing Yao

《化学科学与工程前沿（英文）》 2017年 第11卷 第3期   页码 338-345 doi: 10.1007/s11705-017-1644-0

摘要： To increase the efficiency of dye removal from wastewater using mycelial pellets, a bubble column reactor with a simple structure was designed and efficiently used to remove dyes from solution containing dyes. The mycelial pellets were prepared by marine fungus ZJUBE-1. Eight dyes were tested as dye targets for the adsorption capacity of mycelial pellets and good removal results were obtained. Eriochrome black T was selected as a model dye for characterizing the adsorption processes in detail. The measurement results of Zeta potential and FT-IR analysis indicate that the electrostatic attraction may play a key role in the biosorption process. The bubble column reactor was utilized to study the batch dye-removal efficiency of mycelial pellets. A re-culture process between every two batches, which was under non-sterile condition, successfully enhanced the utilization of mycelium biomass. The dye removal rate is 96.4% after 12 h in the first batch and then decreases slowly in the following batches. This semi-continuous mode, which consists of commutative processes of dye-removal and re-culture, has some outstanding advantages, such as low power consumption, easy operation, high dye removal rate, and efficient biomass utilization.

关键词： dye     mycelial pellets     marine fungus     bubble column reactor     semi-continuous biosorption    

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A continuous/discontinuous deformation analysis (CDDA) method based on deformable blocks for fracture

Yongchang CAI, Hehua ZHU, Xiaoying ZHUANG

《结构与土木工程前沿（英文）》 2013年 第7卷 第4期   页码 369-378 doi: 10.1007/s11709-013-0222-x

摘要： In the framework of finite element meshes, a novel continuous/discontinuous deformation analysis (CDDA) method is proposed in this paper for modeling of crack problems. In the present CDDA, simple polynomial interpolations are defined at the deformable block elements, and a link element is employed to connect the adjacent block elements. The CDDA is particularly suitable for modeling the fracture propagation because the switch from continuous deformation analysis to discontinuous deformation analysis is natural and convenient without additional procedures. The SIFs (stress intensity factors) for various types of cracks, such as kinked cracks or curved cracks, can be easily computed in the CDDA by using the virtual crack extension technique (VCET). Both the formulation and implementation of the VCET in CDDA are simple and straightforward. Numerical examples indicate that the present CDDA can obtain high accuracy in SIF results with simple polynomial interpolations and insensitive to mesh sizes, and can automatically simulate the crack propagation without degrading accuracy.

关键词： fracture     crack     propagation     deformable block     continuous/discontinuous deformation analysis (CDDA)    

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Independent continuous and mapping method of structural topology optimization based on the global stress

Yunkang SUI, Jili FENG, Hongling YE, Xirong PENG,

《机械工程前沿（英文）》 2010年 第5卷 第2期   页码 130-142 doi: 10.1007/s11465-010-0011-3

摘要： There are three difficulties in topology optimization of continuum structures. 1) The topology under multiple load case is more difficult to be optimized than under single load case, because the former becomes a multiple objective based on compliance objective functions. 2) With local constraints, such as an elemental stress limit, the topology is more difficult to be solved than with global constraints, such as the displacement or frequency limits, because the sensitivity analysis of the former has very expensive computation. 3) With the phenomenon of load illness, which is similar with stiffness illness in the structural analysis, it is not easy to get the reasonable final topological structure, because it is difficult to consider different influences between the loads with small forces and big forces, and some topology paths of transferring small forces may disappear during the iteration process. To overcome difficulties above, four measures are adopted. 1) Topology optimization model is established by independent continuous mapping (ICM) method. 2) Based on the von Mises strength theory, all elements’ stress constraints are transformed into a structural energy constraint. 3) The phenomenon of load illness is divided to classify into three cases. 4) A strategy based on strain energy is proposed to adopt ICM method with stress globalization, and the problems of the above mentioned three cases of load illness are solved in terms of different complementary approaches. Several numerical examples show that the topology path of transferring forces can be obtained more easily by substituting global strain energy constraints for local stresses constraints, and the problem of load illness can be solved well by the weighting method that takes the structural energy as a weighting coefficient.

关键词： independent continuous mapping (ICM) method     global stresses constraints     topology optimization     continuum structure     load illness    

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Predicting the response of continuous RC deep beams under varying levels of differential settlement

M. Z. NASER, R. A. HAWILEH

《结构与土木工程前沿（英文）》 2019年 第13卷 第3期   页码 686-700 doi: 10.1007/s11709-018-0506-2

摘要： This paper investigates the effect of differential support settlement on shear strength and behavior of continuous reinforced concrete (RC) deep beams. A total of twenty three-dimensional nonlinear finite element models were developed taking into account various constitutive laws for concrete material in compression (crushing) and tension (cracking), steel plasticity (i.e., yielding and strain hardening), bond-slip at the concrete and steel reinforcement interface as well as unique behavior of spring-like support elements. These models are first validated by comparing numerical predictions in terms of load-deflection response, crack propagation, reaction distribution, and failure mode against that of measured experimental data reported in literature. Once the developed models were successfully validated, a parametric study was designed and performed. This parametric study examined number of critical parameters such as ratio and spacing of the longitudinal and vertical reinforcement, compressive and tensile strength of concrete, as well as degree (stiffness) and location of support stiffness to induce varying levels of differential settlement. This study also aims at presenting a numerical approach using finite element simulation, supplemented with coherent assumptions, such that engineers, practitioners, and researchers can carry out simple, but yet effective and realistic analysis of RC structural members undergoing differential settlements due to variety of load actions.

关键词： concrete     continuous beams     deep beams     finite element modeling     support settlement    

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Automated synthesis of steady-state continuous processes using reinforcement learning

《化学科学与工程前沿（英文）》 2022年 第16卷 第2期   页码 288-302 doi: 10.1007/s11705-021-2055-9

摘要： Automated flowsheet synthesis is an important field in computer-aided process engineering. The present work demonstrates how reinforcement learning can be used for automated flowsheet synthesis without any heuristics or prior knowledge of conceptual design. The environment consists of a steady-state flowsheet simulator that contains all physical knowledge. An agent is trained to take discrete actions and sequentially build up flowsheets that solve a given process problem. A novel method named SynGameZero is developed to ensure good exploration schemes in the complex problem. Therein, flowsheet synthesis is modelled as a game of two competing players. The agent plays this game against itself during training and consists of an artificial neural network and a tree search for forward planning. The method is applied successfully to a reaction-distillation process in a quaternary system.

关键词： automated process synthesis     flowsheet synthesis     artificial intelligence     machine learning     reinforcement learning    

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Microbial community structure and dynamics of starch-fed and glucose-fed chemostats during two years of continuous

Min GOU,Jing ZENG,Huizhong WANG,Yueqin TANG,Toru SHIGEMATSU,Shigeru MORIMURA,Kenji KIDA

《环境科学与工程前沿（英文）》 2016年 第10卷 第2期   页码 368-380 doi: 10.1007/s11783-015-0815-9

摘要： The microbial community structures of two mesophilic anaerobic chemostats, one fed with glucose, the other with starch as sole carbon sources, were studied at various dilution rates (0.05–0.25 d for glucose and 0.025–0.1 d for starch) during two years continuous operation. In the glucose-fed chemostat, the aceticlastic methanogen spp. and hydrogenotrophic methanogen spp. predominated at low dilution rates, whereas spp. and the hydrogenotrophic spp. predominated together when dilution rates were greater than 0.1 d . Bacteria affiliated with the phyla Bacteroidetes, Spirochaetes, and Actinobacteria predominated at dilution rates of 0.05, 0.1, and 0.15 d , respectively, while Firmicutes predominated at higher dilution rates (0.2 and 0.25 d ). In the starch-fed chemostat, the aceticlastic and hydrogenotrophic methanogens coexisted at all dilution rates. Although bacteria belonging to only two phyla were mainly responsible for starch degradation (Spirochaetes at the dilution rate of 0.08 d and Firmicutes at other dilution rates), different bacterial genera were identified at different dilution rates. With the exception of Archaea in the glucose-fed chemostat, the band patterns revealed by denaturing gradient gel electrophoresis (DGGE) of the microbial communities in the two chemostats displayed marked changes during long-term operation at a constant dilution rate. The bacterial community changed with changes in the dilution rate, and was erratic during long-term operation in both glucose-fed and starch-fed chemostats.

关键词： microbial community     glucose degradation     starch degradation     dilution rate     continuous methane fermentation     phylogenetic analysis    

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标题 作者 时间 类型 操作

Strain and process engineering toward continuous industrial fermentation

期刊论文

Ant colony optimization in continuous problem

YU Ling, LIU Kang, LI Kaishi

期刊论文

连续铸钢前沿技术的工程化

干勇

期刊论文

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

期刊论文

Bending and rotational behaviour of semi-continuous composite beams

WANG Jingfeng, LI Guoqiang

期刊论文

Seismic performance of fabricated continuous girder bridge with grouting sleeve-prestressed tendon composite

期刊论文

Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated

期刊论文

Analysis of load transfer stability control strategy in hydraulic synchronized continuous slippage

LIU Yan-bo, WU Jian-zhong, ZHANG Xuan

期刊论文

Non-invasive continuous blood pressure monitoring: a review of current applications

null

期刊论文

Removal of dyes from wastewater by growing fungal pellets in a semi-continuous mode

Tao Lu, Qilei Zhang, Shanjing Yao

期刊论文

A continuous/discontinuous deformation analysis (CDDA) method based on deformable blocks for fracture

Yongchang CAI, Hehua ZHU, Xiaoying ZHUANG

期刊论文

Independent continuous and mapping method of structural topology optimization based on the global stress

Yunkang SUI, Jili FENG, Hongling YE, Xirong PENG,

期刊论文

Predicting the response of continuous RC deep beams under varying levels of differential settlement

M. Z. NASER, R. A. HAWILEH

期刊论文

Automated synthesis of steady-state continuous processes using reinforcement learning

期刊论文

Microbial community structure and dynamics of starch-fed and glucose-fed chemostats during two years of continuous

Min GOU,Jing ZENG,Huizhong WANG,Yueqin TANG,Toru SHIGEMATSU,Shigeru MORIMURA,Kenji KIDA

期刊论文