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Telomeric impact of conventional chemotherapy

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 411-417 doi: 10.1007/s11684-013-0293-z

摘要：

The increased level of chromosome instability in cancer cells, leading to aneuploidy and gross chromosomal rearrangements, is not only a driving force for oncogenesis but also can be the Achille’s heel of the disease since many chemotherapies (CT) kill cells by inducing a non-tolerable rate of DNA damage. A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs. These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres. In agreement with this view, accelerated shortening of telomere length has been described in blood lineage cells following high-dose CT (stem cell transplantation) or non-myeloablative CT. However, almost nothing is known on the consequences of this shortening in terms of telomere stability, senescence and on the development of second cancers or post-treatment aging-like syndromes in cancer survivors (cognitive defect, fertility impairment, etc.). In this article, we propose: (1) telomeres of cancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance; (2) telomere functional parameters can be a surrogate marker of chemotherapy sensitivity and toxicity; (3) the use of anti-telomere molecule could greatly enhance the sensitivity to standards chemotherapies.

关键词： telomere     antineoplasic drugs     conventional chemotherapies    

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Oxygen reduction electrocatalysis: From conventional to single-atomic platinum-based catalysts for proton

《能源前沿（英文）》 doi: 10.1007/s11708-023-0907-3

摘要： Platinum (Pt)-based materials are still the most efficient and practical catalysts to drive the sluggish kinetics of cathodic oxygen reduction reaction (ORR) in proton exchange membrane fuel cells (PEMFCs). However, their catalysis and stability performance still need to be further improved in terms of corrosion of both carbon support and Pt catalyst particles as well as Pt loading reduction. Based on the developed synthetic strategies of alloying/nanostructuring Pt particles and modifying/innovating supports in developing conventional Pt-based catalysts, Pt single-atom catalysts (Pt SACs) as the recently burgeoning hot materials with a potential to achieve the maximum utilization of Pt are comprehensively reviewed in this paper. The design thoughts and synthesis of various isolated, alloyed, and nanoparticle-contained Pt SACs are summarized. The single-atomic Pt coordinating with non-metals and alloying with metals as well as the metal-support interactions of Pt single-atoms with carbon/non-carbon supports are emphasized in terms of the ORR activity and stability of the catalysts. To advance further research and development of Pt SACs for viable implementation in PEMFCs, various technical challenges and several potential research directions are outlined.

关键词： oxygen reduction electrocatalysis     Pt single-atom catalysts     conventional Pt-based catalysts     design thoughts and synthesis     metal-support interactions    

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Esophageal pulse oximetry is more accurate and detects hypoxemia earlier than conventional pulse oximetry

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 406-410 doi: 10.1007/s11684-012-0217-3

摘要：

The esophagus is perfused directly by prominent arteries and may provide a more consistent tissue source for pulse oximetry. The goal of this study was to evaluate the sensitivity and accuracy of an esophageal pulse oximetry probe on patients during controlled hypoxemia in comparison to measurements obtained with conventional pulse oximetry (SpulseO2). Forty-five ASA I–II adult patients were included in this prospective observational study. Nellcor digital oximetric probes were placed on finger tips for SpulseO2 before anesthesia. After tracheal intubation, an esophageal probe was placed in the lower segment of the esophagus for esophageal oximetric monitoring (SoesO2). All patients were disconnected from the breathing circuit to establish a controlled hypoxemia, and were re-connected to the breathing circuit and ventilated with 100% oxygen immediately when SoesO2 dropped to 90%. Matched SoesO2 and SpulseO2 readings were recorded when SoesO2measurements were at 100%, 95%, 90% and the lowest reading. The time for SoesO2 and SpulseO2 to drop from 100% to 95%, 90% and return to 100% was recorded. Oxygen saturation from arterial blood samples (SartO2) was also measured at each time point respectively. The linear correlation coefficient of the regression analysis between SartO2 and SoesO2 was 0.954. The mean±2SD of the difference was 0.3%±4.3% for SoesO2vs. SartO2 and 6.8%±5.6% for SpulseO2vs. SartO2 (P<0.001). The 95% confidence interval for the absolute difference between SoesO2 and SartO2 was 0.3% to 0.7% and 6.2% to 7.4% between SpulseO2 and SartO2. The time to reach 90% saturation measured with SoesO2 was approximately 94 seconds earlier than the SpulseO2 (P<0.001). In conclusion, SoesO2 is more accurate and enables earlier detection of hypoxemia when compared to conventional pulse oximetry during hypoxemia for patients undergoing general anesthesia.

关键词： esophageal pulse oximetry     conventional pulse oximetry     hypoxemia    

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Techno-economic characteristics of wastewater treatment plants retrofitted from the conventional activated

《环境科学与工程前沿（英文）》 doi: 10.1007/s11783-021-1483-6

摘要：

While a growing number of wastewater treatment plants (WWTPs) are being retrofitted from the conventional activated sludge (CAS) process to the membrane bioreactor (MBR) process, the debate on the techno-economy of MBR vs. CAS has continued and calls for a thorough assessment based on techno-economic valuation.

关键词： Membrane bioreactor (MBR)     Conventional activated sludge (CAS)     Cost-benefit analysis     Data envelopment analysis     Net profit    

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Nonlinear experimental response of non-conventional composite steel and concrete connection

Tobia ZORDAN, Bruno BRISEGHELLA

《结构与土木工程前沿（英文）》 2009年 第3卷 第1期   页码 42-49 doi: 10.1007/s11709-008-0058-y

摘要： An experiment was carried out on a set of full-scale specimens of a non-conventional connection between a concrete column and a composite steel and concrete beam defined on the basis of a number of requirements. The proposed connection, conceived in the ambit of semi-rigid joints, is aimed at combining general ease of construction with a highly simplified assembly procedure with a satisfying transmission of hogging moment at supports in continuous beams. For this purpose, the traditional shear studs used at the interface between the steel beam and the upper concrete slab, are also employed at the ends of the steel profiles welded horizontally to the end plates. The test is aimed at investigating the hogging moment response of the connection under incremental loads until failure.

关键词： composite connections     nonlinear behaviour     hogging moment     monotonic tests    

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Innovative hybrid reinforcement constituting conventional longitudinal steel and FRP stirrups for improved

Mostafa FAKHARIFAR,Ahmad DALVAND,Mohammad K. SHARBATDAR,Genda CHEN,Lesley SNEED

《结构与土木工程前沿（英文）》 2016年 第10卷 第1期   页码 44-62 doi: 10.1007/s11709-015-0295-9

摘要： The use of fiber reinforced polymer (FRP) reinforcement is becoming increasingly attractive in construction of new structures. However, the inherent linear elastic behavior of FRP materials up to rupture is considered as a major drawback under seismic attacks when significant material inelasticity is required to dissipate the input energy through hysteretic cycles. Besides, cost considerations, including FRP material and construction of pre-fabricated FRP configurations, especially for stirrups, and probable damage to epoxy coated fibers when transported to the field are noticeable issues. The current research has proposed a novel economical hybrid reinforcement scheme for the next generation of infrastructures implementing on-site fabricated FRP stirrups comprised of FRP sheets. The hybrid reinforcement consists of conventional longitudinal steel reinforcement and FRP stirrups. The key feature of the proposed hybrid reinforcement is the enhanced strength and ductility owing to the considerable confining pressure provided by the FRP stirrups to the longitudinal steel reinforcement and core concrete. Reinforced concrete beam specimens and beam-column joint specimens were tested implementing the proposed hybrid reinforcement. The proposed hybrid reinforcement, when compared with conventional steel stirrups, is found to have higher strength, stiffness, and energy dissipation. Design methods, structural behavior, and applicability of the proposed hybrid reinforcement are discussed in detail in this paper.

关键词： FRP     ductility     confinement     seismic     shear    

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AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS

《农业科学与工程前沿（英文）》 2022年 第9卷 第2期   页码 284-294 doi: 10.15302/J-FASE-2021435

摘要：

Bioenergy, currently the largest renewable energy source in the EU (64% of the total renewable energy consumption), has sparked great interest to meet the 32% renewable resources for the 2030 bioeconomy goal. The design of innovative cropping systems informed by bioeconomy imperatives requires the evaluate of the effects of introducing crops for bioenergy into conventional crop rotations. This study aimed to assess the impacts of changes in conventional cropping systems in mixed dairy cattle farms redesigned to introduce bioenergy crops either by increasing the biomass production through an increase of cover crops, while keeping main feed/food crops, or by substituting food crops with an increase of the crop rotation length. The assessment is based on the comparison between conventional and innovative systems oriented to feed and biogas production, with and without tillage, to evaluate their agri-environmental performances (biomass production, nitrogen fertilization autonomy, greenhouse gas emissions and biogas production). The result showed higher values in the biogas cropping system than in the conventional and feed ones for all indicators, biomass productivity (27% and 20% higher, respectively), nitrogen fertilization autonomy (26% and 73% higher, respectively), methanogenic potential (77% and 41% higher, respectively) and greenhouse gas emissions (15% and 3% higher, respectively). There were no negative impacts of no-till compared to the tillage practice, for all tested variables. The biogas cropping system showed a better potential in terms of agri-environmental performance, although its greenhouse gas emissions were higher. Consequently, it would be appropriate to undertake a multicriteria assessment integrating agri-environmental, economic and social performances.

关键词： alternative cropping systems / bioeconomy / biogas / biomass production / fertilization autonomy / greenhouse gas assessment    

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Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 356-360 doi: 10.1007/s11684-015-0404-0

摘要：

Robotic system has been increasingly used in pancreatectomy. However, the effectiveness of this method remains uncertain. This study compared the surgical outcomes between robot-assisted laparoscopic distal pancreatectomy and conventional laparoscopic distal pancreatectomy. During a 15-year period, 35 patients underwent minimally invasive approach of distal pancreatectomy in our center. Seventeen of these patients had robot-assisted laparoscopic approach, and the remaining 18 had conventional laparoscopic approach. Their operative parameters and perioperative outcomes were analyzed retrospectively in a prospective database. The mean operating time in the robotic group (221.4 min) was significantly longer than that in the laparoscopic group (173.6 min) (P = 0.026). Both robotic and conventional laparoscopic groups presented no significant difference in spleen-preservation rate (52.9% vs. 38.9%) (P = 0.505), operative blood loss (100.3 ml vs. 268.3 ml) (P = 0.29), overall morbidity rate (47.1% vs. 38.9%) (P = 0.73), and post-operative hospital stay (11.4 days vs. 14.2 days) (P = 0.46). Both groups also showed no perioperative mortality. Similar outcomes were observed in robotic distal pancreatectomy and conventional laparoscopic approach. However, robotic approach tended to have the advantages of less blood loss and shorter hospital stay. Further studies are necessary to determine the clinical position of robotic distal pancreatectomy.

关键词： distal pancreatectomy     pancreatic neoplasm     robotic surgery    

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Liquefaction assessment using microtremor measurement, conventional method and artificial neural network

Sadegh REZAEI,Asskar Janalizadeh CHOOBBASTI

《结构与土木工程前沿（英文）》 2014年 第8卷 第3期   页码 292-307 doi: 10.1007/s11709-014-0256-8

摘要： Recent researchers have discovered microtremor applications for evaluating the liquefaction potential. Microtremor measurement is a fast, applicable and cost-effective method with extensive applications. In the present research the liquefaction potential has been reviewed by utilization of microtremor measurement results in Babol city. For this purpose microtremor measurements were performed at 60 measurement stations and the data were analyzed by suing Nakmaura’s method. By using the fundamental frequency and amplification factor, the value of vulnerability index ( ) was calculated and the liquefaction potential has been evaluated. To control the accuracy of this method, its output has been compared with the results of Seed and Idriss [ ] method in 30 excavated boreholes within the study area. Also, the results obtained by the artificial neural network (ANN) were compared with microtremor measurement. Regarding the results of these three methods, it was concluded that the threshold value of liquefaction potential is . On the basis of the analysis performed in this research it is concluded that microtremors have the capability of assessing the liquefaction potential with desirable accuracy.

关键词： liquefaction     microtremor     vulnerability index     artificial neural networks (ANN)     microzonation    

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Developing effective tumor vaccines: basis, challenges and perspectives

XU Qingwen, CHEN Weifeng

《医学前沿（英文）》 2007年 第1卷 第1期   页码 11-19 doi: 10.1007/s11684-007-0003-9

摘要： A remarkable advance in tumor immunology during the last decade is the elucidation of the antigenic basis of tumor recognition and destruction. A variety of tumor antigens have been identified using several strategies including conventional experiments and newly developed bioinformatics. Among these antigens, cancer/testis antigen (CT antigen) is considered to be the most promising target for immunotherapy by vaccination. Successful immunotherapy of tumors requires understanding of the natural relationship between the immune system and tumor in the status of differentiation, invasion and maturation. Continued progress in development of effective cancer vaccines depends on the identification of appropriate target antigens, the establishment of optimal immunization strategies without harmful autoimmune responses and the ability of manipulating tumor microenvironment to circumvent immune suppression and to augment the anti-tumor immune response.

关键词： development     conventional     identification     elucidation     Successful immunotherapy    

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Energy budget and economic analysis in conventional and organic rice production systems and organic scenarios

Hamed MANSOORI, Parviz Rezvani MOGHADDAM, Rooholla MORADI

《能源前沿（英文）》 2012年 第6卷 第4期   页码 341-350 doi: 10.1007/s11708-012-0206-x

摘要： Compared to conventional agriculture, organic agriculture is reported to be more efficient and effective in reducing water and soil pollution, greenhouse gases (GHGs) emission and risk of human health. In additional, field management under organic condition can be useful for increasing energy efficiency. Rice is one of the important crops which are cultivated in two forms, organic and conventional, in Iran. In order to compare the energy efficiency and economic analysis of rice production in organic and conventional systems in Iran, needed information was collected by face-to-face questionnaire in 2011 and three scenarios were designed to predict the changes of energy budget and economic analysis in the transition period that included: 25%, 50% and 75% organic management in rice production. The results showed that all energy indexes were improved in organic rice production compared to conventional condition. Higher values of benefit to cost ratio, gross and net return and lower value of total cost of production were obtained from organic rice production which indicated that the organic management of farm improved economically in comparison with the conventional rice production system. The shares of direct and renewable energies were increased by approach to organic management. Increase in energy efficiency and productivity was predicted for the transition period but decrease trend in economic indexes was projected for this period in all scenarios. The main reason for decreasing economic indexes in organic scenarios was that the market price of organic rice was the same as that of conventional rice in the transition period.

关键词： energy efficiency     specific energy     net return     Cobb-Douglas function    

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Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR

Xiaoyan Song,Rui Liu,Lujun Chen,Tomoki Kawagishi

《环境科学与工程前沿（英文）》 2017年 第11卷 第2期 doi: 10.1007/s11783-017-0919-5

摘要： The BF-MBR displayed higher removal rates of nitrogen, phosphorous and antibiotics. The BF-MBR saved alkali consumption. The removal of antibiotics was influenced significantly by HRT. Membrane filtration greatly contributed to antibiotics removal. A biofilm membrane bioreactor (BF-MBR) and a conventional membrane bioreactor (MBR) were parallelly operated for treating digested piggery wastewater. The removal performance of COD, TN, NH -N, TP as well as antibiotics were simultaneously studied when the hydraulic retention time (HRT) was gradually shortened from 9 d to 1 d and when the ratio of influent COD to TN was changed. The results showed that the effluent quality in both reactors was poor and unstable at an influent COD/TN ratio of 1.0±0.2. The effluent quality was significantly improved as the influent COD/TN ratio was increased to 2.3±0.5. The averaged removal rates of COD, NH -N, TN and TP were 92.1%, 97.1%, 35.6% and 54.2%, respectively, in the BF-MBR, significantly higher than the corresponding values of 91.7%, 90.9%, 17.4% and 31.9% in the MBR. Analysis of 11 typical veterinary antibiotics (from the tetracycline, sulfonamide, quinolone, and macrolide families) revealed that the BF-MBR removed more antibiotics than the MBR. Although the antibiotics removal decreased with a shortened HRT, high antibiotics removals of 86.8%, 80.2% and 45.3% were observed in the BF-MBR at HRT of 5–4 d, 3–2 d and 1 d, respectively, while the corresponding values were only 83.8%, 57.0% and 25.5% in the MBR. Moreover, the BF-MBR showed a 15% higher retention rate of antibiotics and consumed 40% less alkalinity than the MBR. Results above suggest that the BF-MBR was more suitable for digested piggery wastewater treatment.

关键词： Alkalinity     Antibiotics     Biofilm     Digested piggery wastewater (DPW)     Membrane bioreactor    

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Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional

Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA

《环境科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 43-48 doi: 10.1007/s11783-012-0397-8

摘要： The effects of hydraulic retention time (HRT) on the nitrification activities and population dynamics of a conventional activated sludge system fed with synthetic inorganic wastewater were investigated over a period of 260 days. When the HRT was gradually decreased from 30 to 5 h, the specific ammonium-oxidizing rates (SAOR) varied between 0.32 and 0.45 kg (kg mixed liquor suspended solids (MLSS)·d) , and the specific nitrate-forming rates (SNFR) increased from 0.11 to 0.50 kg (kg MLSS·d) , showing that the decrease in HRT led to a significant increase in the nitrite oxidation activity. According to fluorescence in situ hybridization (FISH) analysis results, the proportion of ammonia-oxidizing bacteria (AOBs) among the total bacteria decreased from 33% to 15% with the decrease in HRT, whereas the fraction of nitrite-oxidizing bacteria (NOBs), particularly the fast-growing sp., increased significantly (from 4% to 15% for NOBs and from 1.5% to 10.6% for sp.) with the decrease in HRT, which was in accordance with the changes in SNFR. A short HRT favored the relative growth of NOBs, particularly the fast-growing sp., in the conventional activated sludge system.

关键词： ammonia-oxidizing bacteria     hydraulic retention time     nitrification activity     nitrite-oxidizing bacteria     population dynamics    

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Advantages of intermittently aerated SBR over conventional SBR on nitrogen removal for the treatment

Xiaoyan Song, Rui Liu, Lujun Chen, Baogang Dong, Tomoki Kawagishi

《环境科学与工程前沿（英文）》 2017年 第11卷 第3期 doi: 10.1007/s11783-017-0941-7

摘要： An intermittently aerated sequencing batch reactor (IASBR) and a traditional sequencing batch reactor (SBR) were parallelly constructed to treat digested piggery wastewater, which was in high NH -N concentration but in a low COD/TN ratio. Their pollutant removal performance was compared under COD/TN ratios of 1.6–3.4 d and hydraulic retention times of 5–3 d. The results showed that the IASBR removed TN, NH -N and TOC more efficiently than the SBR. The average removal rates of TN, NH -N and TOC were 83.1%, 96.5%, and 89.0%, respectively, in the IASBR, significantly higher than the corresponding values of 74.8%, 82.0%, and 86.2% in the SBR. Mass balance of organic carbon revealed that the higher TN removal in the IASBR might be attributed to its efficient utilization of the organic carbon for denitrification, since that 48.7%–52.2% of COD was used for denitrification in the IASBR, higher than the corresponding proportion of 43.1%–47.4% in the SBR. A pre-anoxic process in the IASBR would enhance the ammonium oxidation while restrict the nitrite oxidation. Anoxic duration of 40–80 min should be beneficial for achieving stable nitritation.

关键词： Anoxic stress     Carbon source     Digested piggery wastewater     Intermittently aerated SBR (IASBR)     Total nitrogen    

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Cultivation of aerobic granular sludge in a conventional, continuous flow, completely mixed activated

Xi CHEN,Linjiang YUAN,Wenjuan LU,Yuyou LI,Pei LIU,Kun NIE

《环境科学与工程前沿（英文）》 2015年 第9卷 第2期   页码 324-333 doi: 10.1007/s11783-014-0627-3

摘要： Aerobic granules were formed in a conventional, continuous flow, completely mixed activated sludge system (CMAS). The reactor was inoculated with seed sludge containing few filaments and fed with synthetic municipal wastewater. The settling time of the sludge and the average dissolved oxygen (DO) of the reactor were 2 h and 4.2 mg·L , respectively. The reactor was agitated by a stirrer, with a speed of 250 r·min , to ensure good mixing．The granular sludge had good settleability, and the sludge volume index (SVI) was between 50 and 90 mL·g . The laser particle analyzer showed the diameter of the granules to be between 0.18 and 1.25 mm. A scanning electron microscope (SEM) investigation revealed the predominance of sphere-like and rod-like bacteria, and only few filaments grew in the granules. The microbial community structure of the granules was also analyzed by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE). Sequencing analysis indicated the dominant species were α, β, and γ- , , and . The data from the study suggested that aerobic granules could form, if provided with sufficient number of filaments and high shear force. It was also observed that a high height-to-diameter ratio of the reactor and short settling time were not essential for the formation of aerobic granular sludge.

关键词： aerobic granular sludge     completely mixed activated sludge system (CMAS)     continuous flow     shear force     filamentous bacteria     polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE)    

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标题 作者 时间 类型 操作

Telomeric impact of conventional chemotherapy

null

期刊论文

Oxygen reduction electrocatalysis: From conventional to single-atomic platinum-based catalysts for proton

期刊论文

Esophageal pulse oximetry is more accurate and detects hypoxemia earlier than conventional pulse oximetry

null

期刊论文

Techno-economic characteristics of wastewater treatment plants retrofitted from the conventional activated

期刊论文

Nonlinear experimental response of non-conventional composite steel and concrete connection

Tobia ZORDAN, Bruno BRISEGHELLA

期刊论文

Innovative hybrid reinforcement constituting conventional longitudinal steel and FRP stirrups for improved

Mostafa FAKHARIFAR,Ahmad DALVAND,Mohammad K. SHARBATDAR,Genda CHEN,Lesley SNEED

期刊论文

AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS

期刊论文

Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study

null

期刊论文

Liquefaction assessment using microtremor measurement, conventional method and artificial neural network

Sadegh REZAEI,Asskar Janalizadeh CHOOBBASTI

期刊论文

Developing effective tumor vaccines: basis, challenges and perspectives

XU Qingwen, CHEN Weifeng

期刊论文

Energy budget and economic analysis in conventional and organic rice production systems and organic scenarios

Hamed MANSOORI, Parviz Rezvani MOGHADDAM, Rooholla MORADI

期刊论文

Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR

Xiaoyan Song,Rui Liu,Lujun Chen,Tomoki Kawagishi

期刊论文

Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional

Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA

期刊论文

Advantages of intermittently aerated SBR over conventional SBR on nitrogen removal for the treatment

Xiaoyan Song, Rui Liu, Lujun Chen, Baogang Dong, Tomoki Kawagishi

期刊论文

Cultivation of aerobic granular sludge in a conventional, continuous flow, completely mixed activated

Xi CHEN,Linjiang YUAN,Wenjuan LU,Yuyou LI,Pei LIU,Kun NIE

期刊论文