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spp., foodborne pathogens threatening neonates and infants
Qiming CHEN, Yang ZHU, Zhen QIN, Yongjun QIU, Liming ZHAO
《农业科学与工程前沿（英文）》 2018年 第5卷 第3期 页码 330-339 doi: 10.15302/J-FASE-2018208
Cronobacter spp. (formerly Enterobacter sakazakii) are special foodborne pathogens. Cronobacter infection can cause necrotizing enterocolitis, sepsis and meningitis in all age groups, especially neonates and infants, with a high fatality of up to 80%, although the infection is rare. Outbreaks of Cronobacter infection are epidemiologically proven to be associated with contaminated powdered infant formula (PIF). Cronobacter spp. can resist dry environments and survive for a long period in food with low water activity. Therefore, Cronobacter spp. have become serious pathogens of neonates and infants, as well as in the dairy industry. In this review, we present the taxonomy, pathogenesis, resistance, detection and control of Cronobacter spp.
关键词： Cronobacter spp. desiccation resistance pathogen control pathogen detection powdered infant formula
Surface modification of cellulose nanocrystals
WANG Neng, DING Enyong, CHENG Rongshi
《化学科学与工程前沿（英文）》 2007年 第1卷 第3期 页码 228-232 doi: 10.1007/s11705-007-0041-5
关键词： acetylation degradation transform microscopy desiccation
Prevalence of antifolate drug resistance markers in in China
《医学前沿（英文）》 2022年 第16卷 第1期 页码 83-92 doi: 10.1007/s11684-021-0894-x
关键词： drug resistance antifolates molecular markers Plasmodium vivax China
Metagenomic analysis on resistance genes in water and microplastics from a mariculture system
《环境科学与工程前沿（英文）》 2022年 第16卷 第1期 页码 4-4 doi: 10.1007/s11783-021-1438-y
Microplastics existing widely in different matrices have been regarded as a reservoir for emerging contaminants. Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs). However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system at the presence of microplastics is needed.
关键词： Antibiotic resistance genes Metal resistance genes Metagenomic analysis Microplastics Mariculture
Taking advantage of drug resistance, a new approach in the war on cancer
null
《医学前沿（英文）》 2018年 第12卷 第4期 页码 490-495 doi: 10.1007/s11684-018-0647-7
Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
关键词： cancer drug resistance genetic screens senescence targeted therapy
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
《医学前沿（英文）》 2022年 第16卷 第5期 页码 701-713 doi: 10.1007/s11684-022-0951-0
关键词： acquired resistance EGFR inhibitor apoptosis lung cancer
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
《农业科学与工程前沿（英文）》 2020年 第7卷 第3期 页码 329-332 doi: 10.15302/J-FASE-2020333
The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.
关键词： agroecosystem antibiotic resistance public health soil-plant system
《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1342-x
• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.
关键词： Pig manure Antibiotics Anaerobic digestion Resistance genes Microbial community
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
关键词： Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
Insulin resistance and the metabolism of branched-chain amino acids
null
《医学前沿（英文）》 2013年 第7卷 第1期 页码 53-59 doi: 10.1007/s11684-013-0255-5
Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders. IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network. Branched-chain amino acids (BCAAs), namely valine, leucine and isoleucine, are among the nine essential amino acids, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency. Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight, it is only recently that BCAAs are found to be closely associated with IR. This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies.
关键词： branched-chain amino acids leucine isoleucine valine insulin resistance
Correlation between tension softening relation and crack extension resistance in concrete
Xiufang ZHANG , Shilang XU ,
《结构与土木工程前沿（英文）》 2009年 第3卷 第3期 页码 323-329 doi: 10.1007/s11709-009-0041-2
关键词： concrete fracture process zone crack extension GR resistance tension softening curve
《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1415-5
• ARGs were detected in livestock manure, sludge, food waste and fermentation dregs.
关键词： Antibiotic resistance genes Organic solid waste Aerobic composting Livestock manure Sludge
Characteristics of two transferable aminoglycoside resistance plasmids in
Chengjun Pu, Xiaoyan Gong, Ying Sun
《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1119-2
pRKZ3 is a non-conjugative IncQ plasmid, while pKANJ7 is a conjugative IncX plasmid. The optimal mating time of pKANJ7 varied under different conditions. Both of the two transferable ARPs had little impact on the growth of their hosts. A relatively high level of fitness cost was observed for pKANJ7. The fitness cost of ARPs depended on their hosts.
关键词： Escherichia coli Characteristics Aminoglycoside resistance plasmids Transfer Persistence
Mengli Wang, Ruying Li, Qing Zhao
《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1127-2
Sludge digestion is critical to control the spread of ARGs from wastewater to soil. Fate of ARGs in three pretreatment-AD processes was investigated. UP was more efficient for ARGs removal than AP and THP in pretreatment-AD process. The total ARGs concentration showed significant correlation with 16S rRNA gene. The bacteria carrying ARGs could be mainly affiliated with Proteobacteria.
关键词： Tetracycline resistance genes Sulfonamide resistance genes 16S rRNA gene Sludge pretreatment Anaerobic sludge digestion
《环境科学与工程前沿（英文）》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1521-z
• UV/chlorine can effectively remove VBNC pathogens, ARGs and MGEs in reclaimed water.
关键词： UV/chlorine process Pathogen Antibiotic resistance genes High-throughput qPCR Reclaimed water
标题 作者 时间 类型 操作
spp., foodborne pathogens threatening neonates and infants
Qiming CHEN, Yang ZHU, Zhen QIN, Yongjun QIU, Liming ZHAO
期刊论文
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
期刊论文
swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance
期刊论文
Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
期刊论文
Correlation between tension softening relation and crack extension resistance in concrete
Xiufang ZHANG , Shilang XU ,
期刊论文
Environmental effects and risk control of antibiotic resistance genes in the organic solid waste aerobic
期刊论文
Characteristics of two transferable aminoglycoside resistance plasmids in
Chengjun Pu, Xiaoyan Gong, Ying Sun
期刊论文
Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline
Mengli Wang, Ruying Li, Qing Zhao
期刊论文
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