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CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO
《农业科学与工程前沿（英文）》 2021年 第8卷 第2期
Electrical signals commonly occur in plants in response to various environmental changes and have a dominant function in plant acclimation. The transduction of wound-elicited electrical signals in the model plant species Arabidopsis has been characterized but the characteristics of electrical signal transduction in response to herbivory or wounding in crop species remain unknown. Here, the features of electrical signals elicited by insect herbivory and wounding in tomato were investigated. Unlike those in Arabidopsis, wounding tomato leaves did not cause leaf-to-leaf electrical signal transduction. In contrast, electrical signals elicited in response to petiole wounding were stronger and more strongly transduced. Leaflet wounding also activated electrical signal transduction and jasmonic acid (JA) signaling within the whole compound leaf. It was also demonstrated that tomato glutamate receptor-like 3.3 (GLR3.3) and GLR3.5 mediated leaflet-to-leaflet electrical signal transduction. Herbivory-induced JA accumulation and Helicoverpa armigera resistance were reduced in glr3.3/3.5 plants. This work reveals the nature of electrical signal transduction in tomato and emphasizes the key roles of GLR3.3 and GLR3.5 in electrical signal transduction and JA signaling activation.
关键词： electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
《医学前沿（英文）》 2021年 第15卷 第2期 页码 292-301 doi: 10.1007/s11684-020-0806-5
关键词： bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
null
《医学前沿（英文）》 2015年 第9卷 第3期 页码 288-303 doi: 10.1007/s11684-015-0412-0
Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self-renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.
关键词： TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
《医学前沿（英文）》 2020年 第14卷 第1期 页码 81-90 doi: 10.1007/s11684-019-0692-x
关键词： soluble C-type lectin-like receptor-2 coronary artery disease risk factor
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
《医学前沿（英文）》 2010年 第4卷 第2期 页码 225-228 doi: 10.1007/s11684-010-0003-z
关键词： bradykinin vascular smooth muscle cells signal transduction pathways
Group III metabotropic glutamate receptors and drug addiction
null
《医学前沿（英文）》 2013年 第7卷 第4期 页码 445-451 doi: 10.1007/s11684-013-0291-1
Neuroadaptations of glutamatergic transmission in the limbic reward circuitry are linked to persistent drug addiction. Accumulating data have demonstrated roles of ionotropic glutamate receptors and group I and II metabotropic glutamate receptors (mGluRs) in this event. Emerging evidence also identifies Gαi/o-coupled group III mGluRs (mGluR4/7/8 subtypes enriched in the limbic system) as direct substrates of drugs of abuse and active regulators of drug action. Auto- and heteroreceptors of mGluR4/7/8 reside predominantly on nerve terminals of glutamatergic corticostriatal and GABAergic striatopallidal pathways, respectively. These presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain basal ganglia homeostasis. In response to operant administration of common addictive drugs, such as psychostimulants (cocaine and amphetamine), alcohol and opiates, limbic group III mGluRs undergo drastic adaptations to contribute to the enduring remodeling of excitatory synapses and to usually suppress drug seeking behavior. As a result, a loss-of-function mutation (knockout) of individual group III receptor subtypes often promotes drug seeking. This review summarizes the data from recent studies on three group III receptor subtypes (mGluR4/7/8) expressed in the basal ganglia and analyzes their roles in the regulation of dopamine and glutamate signaling in the striatum and their participation in the addictive properties of three major classes of drugs (psychostimulants, alcohol, and opiates).
关键词： group III metabotropic glutamate receptors cocaine amphetamine alcohol opiate
《农业科学与工程前沿（英文）》 2021年 第8卷 第2期
D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plants that operate under adverse conditions. Here, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1 protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and high light conditions (HH, 35°C, 1000 µmol·m-2·s-1). SM and DTT treatments significantly reduced the net photosynthetic rate, apparent quantum efficiency, maximum photochemical efficiency, and potential activity of photosystem II, leading to photoinhibition and a decline in plant biomass under HH. The increase in reactive oxygen species levels resulted in thylakoid membrane lipid peroxidation. In addition, there were increased non-photochemical quenching and decreased chlorophyll pigments in SM and DTT application, causing an inhibition of D1 protein production at both transcriptional and translational levels. Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition. Additionally, the recovery levels of most photosynthesis indicators in DTT-treated plants were higher than in SM-treated plants. These findings support the view that D1 turnover has a more important role than XC in photoprotection in tomato under HH conditions.
关键词： D1 turnover / photoinhibition / photoprotection / photosynthesis / tomato / xanthophyll cycle
LIU Rui, ZHOU Qixing, ZHANG Lanying, GUO Hao
《环境科学与工程前沿（英文）》 2007年 第1卷 第1期 页码 114-119 doi: 10.1007/s11783-007-0021-5
关键词： monosodium glutamate different inhibitory pollution exposure half-effect
PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (
Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI
《农业科学与工程前沿（英文）》 页码 262-279 doi: 10.15302/J-FASE-2021383
关键词： D1 turnover photoinhibition photoprotection photosynthesis tomato xanthophyll cycle
《农业科学与工程前沿（英文）》 2021年 第8卷 第2期
Fruit cracking is a major disorder that affects the integrity of fruit and reduces the commercial value of tomato and other fleshy fruit. Here, we have found a novel fruit ‘netted-cracking’ (FNC) phenotype in tomato introgression line IL4-4 which is present in neither the donor parent (LA0716) nor the receptor parent (M82). An F2 population was generated by crossing IL4-4 with M82 to genetically characterize the FNC gene and this showed that a single dominant gene determined fruit netted-cracking. Further map-based cloning narrowed down the FNC locus to a 230 kb region on chromosome 4. Sequencing and annotation analysis show that FNC(Solyc04 g082540) was the most likely candidate gene. Functional characterization of FNC by overexpressing FNCAC and FNCIL4-4resulted in the fruit netted-cracking phenotype, suggesting that the FNC transcript level results in the functional gain of fruit netted-cracking. These findings were further confirmed by FNC ortholog in netted-cracking pepper and melon, indicating a common regulatory mechanism in different plant species. Furthermore, cytoplasm and nucleus-localized FNC indicates increased expression of genes involved in suberin, lignin, lipid transport and cell wall metabolism. These findings provide novel genetic insights into fruit netted-cracking and offer a way to promote molecular improvement toward cracking resistant cultivars.
关键词： fine mapping / fruit netted-cracking / introgression line / transcript level
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
《医学前沿（英文）》 2012年 第6卷 第1期 页码 35-40 doi: 10.1007/s11684-012-0171-0
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
关键词： α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
Recycling Materials from Waste Electrical and Electronic Equipment
Jinhui Li
《环境科学与工程前沿（英文）》 2017年 第11卷 第5期 doi: 10.1007/s11783-017-1001-z
Engineering Fronts in fields of Energy and Electrical Science and Technologies in the report of
《能源前沿（英文）》 doi: 10.1007/s11708-023-0868-6
《医学前沿（英文）》 2021年 第15卷 第5期 页码 740-749 doi: 10.1007/s11684-020-0794-5
关键词： brain–computer interface functional electrical stimulation electroencephalogram laterality coefficient chronic stroke
单萜类化合物芳樟醇、甲基丁香酚、草蒿脑和香茅醛对配体门控离子通道的作用模式 Article
Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen
《工程（英文）》 2020年 第6卷 第5期 页码 541-545 doi: 10.1016/j.eng.2019.07.027
在传统的医学治疗中，精油被用作镇静剂、抗惊厥剂以及局部麻醉剂，还可以用作储藏食品、水果、蔬菜和谷物等的防腐剂，同时，它还能用作食品生产的生物农药。芳樟醇（LL）以及其他一些主要组分，如甲基丁香酚（ME）、草蒿脑（EG）和香茅醛是许多精油（如罗勒精油）中的活性化学成分。罗勒精油以及上述单萜类化合物在驱除害虫等方面有明显的功效。然而，这些化学成分的作用机制尚不明确。众所周知，γ-氨基丁酸A型受体（GABAAR）和烟碱型乙酰胆碱受体（nAChR）是目前市场上使用的合成杀虫剂的主要分子靶标。此外，GABAAR靶向治疗也已经有了数十年的临床应用实践，如巴比妥类药物和苯二氮类药物。在本研究中，我们研究了LL、ME、EG和香茅醛对GABAAR和nAChR的电生理作用，以进一步了解它们作为传统药物治疗剂和杀虫剂的多功能性。研究结果表明，LL对GABAAR和nAChR均有抑制作用，这或许可以解释LL的杀虫活性。LL是GABAAR的一种浓度依赖性、非竞争性抑制剂，因为在实验中我们发现，小鼠α1β3γ2L GABAAR的γ-氨基丁酸（GABA）半最大效应浓度（EC50）值不受LL影响：在LL不存在或存在5 mmol·L–1 LL的情况下，该半最大效应浓度值分别为(36.2 ± 7.9) μmol·L–1以及(36.1 ± 23.8) μmol·L–1。LL对GABAAR的半抑制浓度（IC50）约为3.2 mmol·L–1。考虑到在精油之中存在着多种单萜类化合物，所以LL可能与此前被表征为GABAAR激动剂和正变构调节物的ME以及其他单萜类化合物具有协同作用，这为LL的镇静、抗惊厥效用和杀虫活性提供了一种可能的解释。
关键词： 精油 γ-氨基丁酸A型受体 芳樟醇 单萜 烟碱型乙酰胆碱受体
标题 作者 时间 类型 操作
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via theToll-like receptor 4 signaling pathway
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
期刊论文
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
null
期刊论文
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
期刊论文
Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involvedsignal transduction pathways
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
期刊论文
PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER
期刊论文
Toxic effects of wastewater from various phases of monosodium glutamate production on seed germination
LIU Rui, ZHOU Qixing, ZHANG Lanying, GUO Hao
期刊论文
PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (
Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI
期刊论文
FUNCTIONAL GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OF
期刊论文
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
期刊论文
Engineering Fronts in fields of Energy and Electrical Science and Technologies in the report of
期刊论文
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and
期刊论文
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