Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 6

年份

2021 1

2020 1

2015 1

2011 2

2008 1

关键词

光学活检 1

共聚焦内窥镜 1

微生物组 1

症状 1

细胞分辨率 1

肝硬化 1

胃镜 1

静脉曲张 1

展开︾

检索范围：

排序：展示方式：

Capsule endoscopy—A mechatronics perspective

Lin LIN, Mahdi RASOULI, Andy Prima KENCANA, Su Lim TAN, Kai Juan WONG, Khek Yu HO, Soo Jay PHEE

《机械工程前沿（英文）》 2011年第6卷第1期页码 33-39 doi: 10.1007/s11465-011-0203-5

摘要：

The recent advances in integrated circuit technology, wireless communication, and sensor technology have opened the door for development of miniature medical devices that can be used for enhanced monitoring and treatment of medical conditions. Wireless capsule endoscopy is one of such medical devices that has gained significant attention during the past few years. It is envisaged that future wireless capsule endoscopies replace traditional endoscopy procedures by providing advanced functionalities such as active locomotion, body fluid/tissue sampling, and drug delivery. Development of energy-efficient miniaturized actuation mechanisms is a key step toward achieving this goal. Here, we review some of the actuators that could be integrated into future wireless capsules and discuss the existing challenges.

关键词： wireless capsule endoscopy ingestible medical device in-body medical device medical robot miniature actuator

HTML PDF 收藏

Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

《医学前沿（英文）》 2020年第14卷第4期页码 511-517 doi: 10.1007/s11684-020-0742-4

摘要： Artificial intelligence (AI) is coming to medicine in a big wave. From making diagnosis in various medical conditions, following the latest advancements in scientific literature, suggesting appropriate therapies, to predicting prognosis and outcome of diseases and conditions, AI is offering unprecedented possibilities to improve care for patients. Gastroenterology is a field that AI can make a significant impact. This is partly because the diagnosis of gastrointestinal conditions relies a lot on image-based investigations and procedures (endoscopy and radiology). AI-assisted image analysis can make accurate assessment and provide more information than conventional analysis. AI integration of genomic, epigenetic, and metagenomic data may offer new classifications of gastrointestinal cancers and suggest optimal personalized treatments. In managing relapsing and remitting diseases such as inflammatory bowel disease, irritable bowel syndrome, and peptic ulcer bleeding, convoluted neural network may formulate models to predict disease outcome, enhancing treatment efficacy. AI and surgical robots can also assist surgeons in conducting gastrointestinal operations. While the advancement and new opportunities are exciting, the responsibility and liability issues of AI-assisted diagnosis and management need much deliberations.

关键词： artificial intelligence endoscopy robotics gastrointestinal diseases

HTML PDF 收藏

Endoscopic resection of a huge Brunner's gland adenoma

ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong

《医学前沿（英文）》 2008年第2卷第4期页码 414-418 doi: 10.1007/s11684-008-0080-4

摘要： Brunner’s gland adenoma is a rare tumour of the duodenum, which is usually benign. A 71-year-old woman presenting with epigastric pain, upper gastrointestinal haemorrhage and melaena was reported in this paper. Upper gastro-intestinal (GI) endoscopy revealed a large pedunculated tumour on the superior part of the duodenal bulb. Endoscopic polypectomy was successfully performed by clipping and nylon thread without any complications. Histological examination revealed a Brunner’s gland adenoma.

关键词： superior Histological examination endoscopy gastro-intestinal gastrointestinal haemorrhage

HTML PDF 收藏

用于细胞成像的共聚焦内窥镜 Article

王家福,杨敏,杨莉,张云,袁菁,刘谦,侯晓华,付玲

《工程（英文）》 2015年第1卷第3期页码 351-360 doi: 10.15302/J-ENG-2015081

摘要：

使用内窥镜的目的是实现与组织病理诊断相符的即时诊断。在过去的十年里，共聚焦激光扫描显微成像技术被引入内窥镜领域。共聚焦内窥镜使得对活体组织的显微观察能够达到与组织学样品的体外显微成像相当的放大倍数和分辨率。发展这种内窥镜的主要挑战在于具有微米级分辨率的显微成像光纤探头的小型化。笔者研制了一套基于光纤束，分辨率为1.4 μm，成像速度可达8 fps的共聚焦内窥镜系统。光纤探头的直径为2.6 mm，可与常规内窥镜的活检通道兼容。该共聚焦内窥镜的样机已经被用于观察小鼠胃肠道上皮细胞，并将进一步被用于临床试验。此外，该共聚焦内窥镜能够被用于上皮细胞功能的转化研究，以监测自然生理环境中细微颗粒的功能和细胞间的相互作用。

关键词：细胞分辨率共聚焦内窥镜光学活检

HTML PDF 收藏

Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract

Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE

《机械工程前沿（英文）》 2011年第6卷第1期页码 40-44 doi: 10.1007/s11465-011-0204-4

摘要：

Wireless capsule endoscopy has become a common procedure for diagnostic inspection of gastrointestinal tract. This method offers a less-invasive alternative to traditional endoscopy by eliminating uncomfortable procedures of the traditional endoscopy. Moreover, it provides the opportunity for exploring inaccessible areas of the small intestine. Current capsule endoscopes, however, move by peristalsis and are not capable of detailed and on-demand inspection of desired locations. Here, we propose and develop two wireless endoscopes with maneuverable vision systems to enhance diagnosis of gastrointestinal disorders. The vision systems in these capsules are equipped with mechanical actuators to adjust the position of the camera. This may help to cover larger areas of the digestive tract and investigate desired locations. The preliminary experimental results showed that the developed platform could successfully communicate with the external control unit via human body and adjust the position of camera to limited degrees.

关键词： wireless capsule endoscopy ingestible medical device in-body medical device miniature actuator medical robot medical imaging

HTML PDF 收藏

肝硬化患者胃黏膜微生物菌群特征及其与胃肠道症状的相关性分析 Article

陈燕飞, 郭静, 陈春雷, 石鼎, 方戴琼, 季峰, 李兰娟

《工程（英文）》 2021年第7卷第4期页码 507-514 doi: 10.1016/j.eng.2020.04.014

摘要：

研究表明，肝硬化患者的口腔和肠道微生物群与健康人群存在差异。胃位于口腔和肠道之间，关于其黏膜微生物群结构所知甚少。本研究采用16S rRNA焦磷酸测序技术分析了肝硬化患者和对照组的胃黏膜微生物群。研究发现，组织学和测序法均证实肝硬化患者幽门螺杆菌感染率显著降低。在幽门螺杆菌阴性人群中，可以按细菌组成结构将胃黏膜微生物群分为4个聚类，其中聚类1和2主要是肝硬化患者，聚类3主要是健康人群，而聚类4中肝硬化患者和健康人群各占一半左右。这些不同聚类间的成分和功能存在显著差异。在属的水平上，聚类1和2分别富集奈瑟菌和链球菌。在功能基因分类上，相对而言，聚类2缺乏涉及遗传信息处理以及与聚糖生物合成和代谢相关的功能基因。胃黏膜菌群结构表现为聚类2的患者胃肠道症状更严重，既往内镜下曲张静脉的治疗率显著高于其他组。我们的研究结果表明，在肝硬化中，幽门螺杆菌和非幽门螺杆菌的定植都受到影响。虽然幽门螺杆菌阴性的胃黏膜微生物结构表现出相当大的异质性，但特定的胃微生物群与临床特征之间仍然存在相关性。既往内镜下静脉曲张治疗会引起胃黏膜菌群结构明显改变，从而加重幽门螺杆菌阴性肝硬化患者的胃肠道症状。

关键词：微生物组肝硬化症状静脉曲张胃镜