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《医学前沿（英文）》 2018年 第12卷 第3期 页码 340-349 doi: 10.1007/s11684-017-0565-0
Benralizumab is a monoclonal antibody that targets interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthma. We conducted a meta-analysis to evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthma. All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthma, which were searched in PubMed, Embase, and the Cochrane Library published until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthma control, quality of life scores, and adverse events were included. Randomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative risks, and 95% confidence intervals. Five studies involving 1951 patients were identified. Compared with the placebo, benralizumab treatment demonstrated significant improvements in the forced expiratory volume in 1?s (FEV1), Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control Questionnaire-6 (ACQ-6) scores. Benralizumab treatment was also not associated with increased adverse events. These findings indicated that benralizumab can be safely used to improve FEV1, enhance patient symptom control and quality of life, and reduce the risk of exacerbations and ACQ-6 scores in patients with eosinophilic asthma. Furthermore, our meta-analysis showed that benralizumab with 30 mg (every eight weeks) dosage can improve the health-related quality of life and appear to be more effective than 30 mg (every four weeks) dosage. Overall, data indicated that the optimal dosing regimen for benralizumab was possibly 30 mg (every eight weeks).
关键词： benralizumab anti-interleukin-5 monoclonal antibody eosinophilic asthma meta-analysis
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《医学前沿（英文）》 2016年 第10卷 第2期 页码 191-203 doi: 10.1007/s11684-016-0450-2
The relationship between telomere length and cancer survival has been widely studied. To gain a deeper insight, we reviewed the published studies. A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomere length in the tumor tissue. First, in the peripheral blood studies, for solid tumor patients with shortened telomere length, the combined hazard ratios (HRs) for mortality and tumor progression were 1.21 (95%CI, 1.10–1.32) and 1.71 (95%CI, 1.37–2.13), respectively. Meanwhile, in hematology malignancy, the combined HRs for mortality and tumor progression were 2.83 (95%CI, 2.14–3.74) and 2.65 (95%CI, 2.18–3.22), respectively. Second, in the studies that use tumor tissue, for patients with shortened telomeres, the combined HRs for mortality and tumor progression were 1.26 (95%CI, 0.95–1.66) and 1.65 (95%CI, 1.26–2.15), respectively. In the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, for patients with lower telomere length ratios, the combined HRs were 0.66 (95%CI, 0.53–0.83) and 0.74 (95%CI, 0.41–1.32) for mortality and tumor progression, respectively. In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival for cancer patients. However, by calculating the telomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival.
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《医学前沿（英文）》 2012年 第6卷 第1期 页码 94-99 doi: 10.1007/s11684-012-0181-y
Systematic reviews and meta-analyses are playing an increasingly important role in clinical research and practice. This study aimed to measure the scientific production of systematic review and meta-analysis from the three major regions of China: the Mainland (ML), Hong Kong (HK), and Taiwan (TW). English articles on systematic review and meta-analysis from ML, HK, and TW from 2001 to 2010 were retrieved from the PubMed database. The total number of articles, impact factors (IF), and articles published in high-impact journals were conducted for quantity and quality comparisons among the three regions. There were 1 587 published articles from ML (1 292), HK (203), and TW (92) during the past ten years. The annual total numbers of articles in the three regions increased significantly from 2001 to 2010 (from 13 to 677). The number of articles from ML has exceeded that from TW since 2001, and surpassed that from HK in 2003. The accumulated IF of articles from ML (3 488.24) was higher than those from HK (493.16) and TW (216.39). HK had the highest average IF of 3.31, followed by ML of 2.90 and TW of 2.85. Researchers from HK published a larger proportion of papers in high-impact journals than those from ML and TW. The Cochrane Database of Systematic Reviews was the most popular journal in China. Chinese authors have been very active to enhance the systematic review and meta-analysis research over the past ten years, especially in ML. The gap between ML and the other two regions has been narrowed. But there is still considerable room for Chinese authors to improve their studies on systematic review and meta-analysis.
关键词： systematic review meta-analysis China Chinese impact factor
COMPARING PERFORMANCE OF CROP SPECIES MIXTURES AND PURE STANDS
《农业科学与工程前沿（英文）》 2021年 第8卷 第3期 页码 481-489 doi: 10.15302/J-FASE-2021413
Intercropping is the planned cultivation of species mixtures on agricultural land. Intercropping has many attributes that make it attractive for developing a more sustainable agriculture, such as high yield, high resource use efficiency, lower input requirements, natural suppression of pests, pathogens and weeds, and building a soil with more organic carbon and nitrogen. Information is needed which species combinations perform best under different circumstances and which management is suitable to bring out the best from intercropping in a given production situation. The literature is replete with case studies on intercropping from across the globe, but evidence synthesis is needed to make this information accessible. Meta-analysis requires a careful choice of metric that is appropriate for answering the question at hand, and which lends itself for a robust meta-analysis. This paper reviews some metrics that may be used in the quantitative synthesis of literature data on intercropping.
关键词： intercropping species mixtures meta-analysis metrics indicators
PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa
《医学前沿（英文）》 2008年 第2卷 第3期 页码 259-263 doi: 10.1007/s11684-008-0049-3
Machine perfusion versus cold storage of livers: a meta-analysis
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《医学前沿（英文）》 2016年 第10卷 第4期 页码 451-464 doi: 10.1007/s11684-016-0474-7
Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.
Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong
《医学前沿（英文）》 2021年 第15卷 第1期 页码 125-138 doi: 10.1007/s11684-019-0725-5
关键词： Parkinson’s disease diffusion tensor imaging fractional anisotropy meta-analysis anisotropic effect size–signed differential mapping
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《医学前沿（英文）》 2017年 第11卷 第4期 页码 563-569 doi: 10.1007/s11684-017-0535-6
The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79–1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78–1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.
关键词： blastocyst embryo transfer cumulative pregnancy rate cumulative live birth rate IVF
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《医学前沿（英文）》 2013年 第7卷 第3期 页码 354-366 doi: 10.1007/s11684-013-0257-3
Due to the implementation of directly observed treatment strategy (DOTS), China has made a significant achievement in tackling the tuberculosis (TB) epidemic in the 1990s. However, only half of regions in China met or exceeded the 85% rate of treatment success target. The aim of the present study is to summarize the treatment outcomes of smear-positive pulmonary TB in the mainland of China in the past decade using meta-analysis based on systematic review of published observational studies. A total of 50 eligible articles (58 studies) were identified and included in this study. The summarized treatment success rates were 93.9% (95% CI, 92.8%–94.7%) for new cases and 85.4% (95% CI, 83.0%–87.6%) for previously treated cases, and the summarized cured rate were 92.2% (95% CI, 90.9%–93.3%) and 81.2% (95% CI, 79.1%–83.1%), respectively. A remarkable increase of rates for treatment success and cure was observed in the 1990s. After 2000, the summarized treatment outcomes were tending towards stability. In addition, geographic areas, type of the data and administrative level of the hospital were also found to influence the estimates of the treatment outcomes. Results of the present study clearly show, in general, that the pulmonary TB treatment achieved significant success in the past decade in the mainland of China. However, it needs to be further strengthened in the central and west areas.
Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma
LIU Ting, HE Xiangge
《医学前沿（英文）》 2007年 第1卷 第1期 页码 109-114 doi: 10.1007/s11684-007-0021-7
关键词： inclusion sensitivity analysis correction specificity appropriate
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《医学前沿（英文）》 2017年 第11卷 第2期 页码 191-202 doi: 10.1007/s11684-017-0512-0
Primary hepatic carcinoma (PHC) is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine (TCM). TCM has been widely used to improve the quality of life, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials (RCTs) involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.
关键词： traditional Chinese medicine primary hepatic carcinoma meta-analysis
Qiong DAI MD, Bei LIU MD, Yukai DU MM,
《医学前沿（英文）》 2009年 第3卷 第4期 页码 452-458 doi: 10.1007/s11684-009-0080-z
关键词： meta-analysis breast cancer risk factors reproductive factors oral contraceptive use
基于元分析揭示全球尺度下反硝化反应器中基质材料对硝态氮去除的显著影响 Review
范豫川, 庄杰, Michael Essington, Sindhu Jagadamma, John Schwartz, Jaehoon Lee
《工程（英文）》 2023年 第21卷 第2期 页码 214-226 doi: 10.1016/j.eng.2022.08.017
反硝化生物反应器（DNBR）被广泛用于减少农业废水中过量的硝酸盐。其性能取决于基质的物理和化学性质。在以前的研究中，已经对一部分常见基质做了总结。然而，很少有研究尝试确定基质类型在硝酸盐去除中起作用的一般模式。本研究利用从63篇同行评审文章中收集的数据总结了41种基质类型，包括219个独立DNBR单元。基质分为四类：①天然碳（NC），如木屑；②非天然碳（NNC），如可生物降解聚合物[如聚己内酯（PCL）和废品（如纸板）]；③无机材料（IM），如非碳材料（如氧化铁）;④复合材料（MM），如上述材料的混合物。通过对硝酸盐去除速率[NRR，氮去除（g∙m–3∙d–1）]和硝酸盐去除效率（NRE, %）的元分析，对这些材料进行比较和评估。本文综合阐述了基质效果（NRR和NRE）、潜在机理、污染交换和成本分析。我们的分析表明，木屑和玉米芯是NC中最具成本效益的基质。对比所有参与研究的基质，我们建议将MM作为最优基质，尤其是具有很大的改进空间的基于木屑和玉米芯的基质。该分析有助于优化DNBR的设计，以满足使用者对环境、经济和实用的需求。
Radical versus conservative surgical treatment of liver hydatid cysts: a meta-analysis
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《医学前沿（英文）》 2018年 第12卷 第3期 页码 350-359 doi: 10.1007/s11684-017-0559-y
To date, the efficacy of radical surgery (RS) versus conservative surgery (CS) for liver hydatid cysts (LHC) remains controversial. This meta-analysis was conducted to compare the two interventions. PubMed, Embase, and Web of Science were searched from their inceptions until June 2016. Meta-analysis was performed using STATA 12.0 software. We identified 19 eligible studies from 10 countries by retrieval. In total, 1853 LHC patients who received RS were compared with 2274 patients treated by CS. The risk of postoperative overall complication, biliary fistula, and recurrence was significantly lower, and operation time was significantly longer in the RS group. However, no statistically significant differences were found in terms of mortality risk and the duration of hospital stay between RS and CS. No significant publication biases were observed in all the above analyses. In conclusion, RS reduces the rates of postoperative complications and recurrence, whereas no trend toward such a reduction in mortality was observed in LHC patients.
关键词： liver hydatid cysts radical surgery conservative surgery meta-analysis complications
An update and cumulative meta-analysis
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《医学前沿（英文）》 2014年 第8卷 第2期 页码 241-249 doi: 10.1007/s11684-014-0328-0
Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.
关键词： non-muscle invasive bladder cancer bacillus Calmette-Guérin (BCG) meta-analysis
标题 作者 时间 类型 操作
Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized
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期刊论文
Association between telomere length and survival in cancer patients: a meta-analysis and review of literature
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期刊论文
Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey
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期刊论文
A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against
PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa
期刊论文
Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion
Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong
期刊论文
Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo
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期刊论文
Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis
null
期刊论文
Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma
LIU Ting, HE Xiangge
期刊论文
Chinese medicine combined with Western therapy on primary hepatic carcinoma: a systematic review with meta-analysis
null
期刊论文
Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive
Qiong DAI MD, Bei LIU MD, Yukai DU MM,
期刊论文
基于元分析揭示全球尺度下反硝化反应器中基质材料对硝态氮去除的显著影响
范豫川, 庄杰, Michael Essington, Sindhu Jagadamma, John Schwartz, Jaehoon Lee
期刊论文
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