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农业面源污染 2

大气污染 2

1)幂模型 1

2R-1C模型;嵌入式系统;参数估计;非迭代方法;二次型 1

3D细胞容器 1

Beclin-1 1

GIS 1

GM(1 1

MOF基催化剂 1

PP 1

SARS-CoV-2干扰 1

SIMPLEC算法 1

SPSS 1

WPC 1

circRNA 1

square-twist折纸 1

三点弯曲梁 1

三酰甘油 1

上行非正交多址;Generalized Welch界等式;多级接收功率;序列分组 1

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Current techniques for assessing developmental neurotoxicity of pesticides

GAO Yu, TIAN Ying, SHEN Xiaoming

《医学前沿(英文)》 2008年 第2卷 第4期   页码 337-343 doi: 10.1007/s11684-008-0064-4

摘要: Organophosphates (OPs) and Pyrethroids (PRY) have been widely used in agriculture and in the home as broad spectrum insecticides, but may produce considerable risk to human health, especially to children. Children are more susceptible to environmental exposure, and concern about the neurotoxic effects of pesticide exposure on children is increasing. There is a need for better understanding of the potential developmental neurotoxicity of pesticides. Techniques for assessing developmental neurotoxicity of pesticides will continue to be developed, rendering a need for flexibility of testing paradigms. Current techniques used in evaluating the developmental neurotoxicity of OPs and PRY are presented in this review. These include: (1) techniques (PC12 cells, C6 cells and other cell models); (2) Non-mammalian models (sea urchins, zebrafish and other non-mammalian models); and (3) mammalian models (morphological techniques, neurobehavioral assessments and biomarkers).

关键词: paradigms     Pyrethroids     non-mammalian     susceptible     morphological    

Regeneration of hair cells in the mammalian vestibular system

null

《医学前沿(英文)》 2016年 第10卷 第2期   页码 143-151 doi: 10.1007/s11684-016-0451-1

摘要:

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animals to recover from hearing and balance deficits. Such regeneration does not occur efficiently in humans and other mammals. Thus, balance deficits become permanent and is a common sensory disorder all over the world. Since Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells after gentamicin-induced damage in mature mammals, significant efforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hair cell loss. Moreover, recently many strategies have been developed to promote the hair cell regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch and Atoh1. This article provides an overview of the recent advances in hair cell regeneration in mammalian vestibular epithelia. Furthermore, this review highlights the current limitations of hair cell regeneration and provides the possible solutions to regenerate functional hair cells and to partially restore vestibular function.

关键词: utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian

《医学前沿(英文)》   页码 939-956 doi: 10.1007/s11684-023-0987-9

摘要: A small proportion of mononuclear diploid cardiomyocytes (MNDCMs), with regeneration potential, could persist in adult mammalian heart. However, the heterogeneity of MNDCMs and changes during development remains to be illuminated. To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cell RNA sequencing. Three cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation with close CM–fibroblast (FB) communications and one maintaining MNDCM status with least CM–FB communications. Proliferative MNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cell communications were identified in the third path. The non-pMNDCMs possessed distinct properties: the lowest mitochondrial metabolisms, the highest glycolysis, and high expression of Myl4 and Tnni1. Single-nucleus RNA sequencing and immunohistochemical staining further proved that the Myl4+Tnni1+ MNDCMs persisted in embryonic and adult hearts. These MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data. In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting the importance of microenvironment contribution to CM fate during maturation. These findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providing new clues for approaches to effective cardiac regeneration.

关键词: mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing     cardiac regeneration    

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamousnon-small-cell lung cancer: a retrospective analysis

《医学前沿(英文)》 2022年 第16卷 第4期   页码 610-617 doi: 10.1007/s11684-021-0827-8

摘要: Bevacizumab, an anti-VEGF monoclonal antibody, has significantly improved the clinical outcomes of patients with advanced non-squamous NSCLC (ns-NSCLC). However, the safety and efficacy of bevacizumab for elderly patients with advanced NSCLC require further investigation. Thus, 59 patients were included in the present retrospective study, 22 patients in the bevacizumab plus pemetrexed and platinum (B+PP) group, and 37 patients in the pemetrexed and platinum (PP) group. For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survival rates were 88.5% and 67.8%, respectively. The median OS and 1-year and 2-year OS rates were 20.5 months, 70.3% and 0%, respectively, in the B+PP group and 33.4 months, 97.0% and 89.4%, respectively, in the PP group (P <0.001). The incidence of grade≥3 adverse events was higher in the B+PP group than in the PP group (27.3% vs. 10.8%, respectively; P=0.204). Univariate and multivariate analyses suggested that the receipt of≥5 cycles of first-line chemotherapy was an independent favorable prognostic factor for OS, whereas the addition of bevacizumab was an unfavorable prognostic factor. With increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of elderly patients with advanced ns-NSCLC.

关键词: bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

成年哺乳类神经发生在脊髓损伤修复方面的研究进展

杨朝阳, 赵文, 高钰丹, 段红梅, 郝鹏, 郝飞, 李晓光

《工程(英文)》 2021年 第7卷 第12期   页码 1713-1714 doi: 10.1016/j.eng.2021.09.009

Error analysis of the parameters for non-coaxial grazing X-ray microscope

ZHAO Lingling, HU Jiasheng, LI Xiang

《机械工程前沿(英文)》 2007年 第2卷 第3期   页码 323-329 doi: 10.1007/s11465-007-0057-z

摘要: A non-coaxial grazing X-ray microscope, consisting of four spherical mirrors, is designed for diagnosis of inertial confinement fusion (ICF). The aberrations and imaging quality of the microscope are analyzed. To acquire excellent imaging quality, suitable tolerances for manufacturing and assembling the microscope are necessary. This paper researches the changes of Gauss parameters and aberrations due to component and subsystem parameters (such as the radius of the mirror, angle between mirrors, grazing angle, object distance, etc.). Here, spot diagrams and modulation transfer function (MTF) are first adopted to quantitatively evaluate the imaging quality of the microscope. Suitable manufacturing tolerances of components and assembly tolerances of the system are established on the basis of the discussion and analysis. A set of non-coaxial grazing X-ray microscopes is manufactured based on the tolerances. In site tests of ICF, the images with high resolution are obtained by the microscope.

关键词: non-coaxial     spherical     manufacturing     necessary     diagnosis    

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

《医学前沿(英文)》 2013年 第7卷 第2期   页码 157-171 doi: 10.1007/s11684-013-0272-4

摘要:

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.

关键词: non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression profiling    

The world’s first offshore wind power non-desalination of seawater electrolysis for hydrogen production

《能源前沿(英文)》 2023年 第17卷 第3期   页码 317-319 doi: 10.1007/s11708-023-0888-2

摘要: The world’s first offshore wind power non-desalination of seawater electrolysis for hydrogen production successfully tested in Fujian, China

关键词: China     wind power non    

Identify the contribution of vehicle non-exhaust emissions: a single particle aerosol mass spectrometer

《环境科学与工程前沿(英文)》 2023年 第17卷 第5期 doi: 10.1007/s11783-023-1662-8

摘要:

● A single particle observation was conducted in a high traffic flow road environment.

关键词: Non-exhaust emissions     SPAMS     PMF     Roadside environment    

A conceptual methodology for simultaneous optimization of water and heat with non-isothermal mixing

Yanlong Hou, Wanni Xie, Zhenya Duan, Jingtao Wang

《化学科学与工程前沿(英文)》 2017年 第11卷 第2期   页码 154-165 doi: 10.1007/s11705-016-1593-z

摘要: A new conceptual methodology is proposed to simultaneously integrate water allocation and energy networks with non-isothermal mixing. This method employs a simultaneous model and includes two design steps. In the first step, the water allocation network (WAN), which could achieve the targets of saving water and energy, is obtained by taking account the temperature factor into the design procedure. The optimized targets of both freshwater and energy are reached at this step which ensures this approach is a simultaneous one. In the second step, based on the obtained WAN, the whole water allocation and heat exchange network (WAHEN) is combined with the non-isothermal mixing to reduce the number of heat exchangers. The thus obtained WAHEN can achieve three optimization targets (minimization of water, energy and the number of heat exchangers). Furthermore, the effectivity of our method has been demonstrated by solving two literature examples.

关键词: simultaneous integration     non-isothermal mixing     multi-target optimization     water and energy networks    

FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA

《农业科学与工程前沿(英文)》 2023年 第10卷 第4期   页码 593-606 doi: 10.15302/J-FASE-2023522

摘要:

Ensuring food safety while reducing agricultural non-point source pollution is quite challenging, especially in developing and underdeveloped countries. Effective systematic strategies and comprehensive technologies need to be developed for agricultural non-point source pollution control at the watershed scale to improve surface water quality. In this review, a proposal is made for a full time-space governance strategy that prioritizes source management followed by endpoint water pollution control. The 4R chain technology system is specifically reviewed, including source reduction, process retention, nutrient reuse and water restoration. The 4R chain technology system with the full time-space governance strategy was applied at the scale of an administrative village and proved to be a feasible solution for reducing agricultural non-point source pollution in China. In the future, a monitoring system needs to be established to trace N and P transport. Additionally, new smart fertilizer and intelligent equipment need to be developed, and relevant governance standards and supportive policies need to be set to enhance the efficacy of agricultural non-point source pollution control.

关键词: 4R chain technology system     agricultural non-point source pollution     case study     full time-space governance strategy    

Effect of non-uniform illumination on performance of solar thermoelectric generators

Ershuai YIN, Qiang LI, Yimin XUAN

《能源前沿(英文)》 2018年 第12卷 第2期   页码 239-248 doi: 10.1007/s11708-018-0533-7

摘要: Solar thermoelectric generators (STEGs) are heat engines which can generate electricity from concentrated sunlight. The non-uniform illumination caused by the optical concentrator may affect the performance of solar thermoelectric generators. In this paper, a three-dimensional finite element model of solar thermoelectric generators is established. The two-dimensional Gaussian distribution is employed to modify the illumination profiles incident on the thermoelectric generator. Six non-uniformities of solar illumination are investigated while keeping the total energy constant. The influences of non-uniform illumination on the temperature distribution, the voltage distribution, and the maximum output power are respectively discussed. Three thermoelectric generators with 32, 18 and 8 pairs of thermocouples are compared to investigate their capability under non-uniform solar radiation. The result shows that the non-uniformity of the solar illumination has a great effect on the temperature distribution and the voltage distribution. Central thermoelectric legs can achieve a larger temperature difference and generate a larger voltage than peripheral ones. The non-uniform solar illumination will weaken the capability of the TE generator, and the maximum output power decrease by 1.4% among the range of non-uniformity studied in this paper. Reducing the number of the thermoelectric legs for non-uniform solar illumination can greatly increase the performance of the thermoelectric generator.

关键词: solar thermoelectric generators     non-uniform solar illumination     performance evaluation     solar energy    

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

《医学前沿(英文)》 2016年 第10卷 第2期   页码 137-142 doi: 10.1007/s11684-016-0449-8

摘要:

Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided into syndromic hearing loss (associated with other anomalies) and non-syndromic hearing loss (not associated with other anomalies). Approximately 80% of genetic deafness is non-syndromic. On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided into high-, mid-, low-, and total-frequency hearing loss. An audiometric finding of mid-frequency sensorineural hearing loss, or a “bowl-shaped” audiogram, is uncommon. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness genes.

关键词: hereditary non-syndromic hearing loss     mid-frequency hearing loss     deafness genes    

系统非优分析理论及方法

何平

《中国工程科学》 2003年 第5卷 第7期   页码 40-46

摘要:

对系统非优分析理论做了较为详细的论述。指出寻求不确定系统优化的主要问题,关键是缺少对系统的非优分析。在系统非优范畴的基础上建立了征兆群与经验分析,提出了系统非优度量以及从非优追踪到系统自组织等问题。

关键词: 系统非优范畴     非优征兆群     非优度量     系统自组织    

标题 作者 时间 类型 操作

Current techniques for assessing developmental neurotoxicity of pesticides

GAO Yu, TIAN Ying, SHEN Xiaoming

期刊论文

Regeneration of hair cells in the mammalian vestibular system

null

期刊论文

diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian

期刊论文

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamousnon-small-cell lung cancer: a retrospective analysis

期刊论文

成年哺乳类神经发生在脊髓损伤修复方面的研究进展

杨朝阳, 赵文, 高钰丹, 段红梅, 郝鹏, 郝飞, 李晓光

期刊论文

Error analysis of the parameters for non-coaxial grazing X-ray microscope

ZHAO Lingling, HU Jiasheng, LI Xiang

期刊论文

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

期刊论文

The world’s first offshore wind power non-desalination of seawater electrolysis for hydrogen production

期刊论文

周波:Do Energy Subsidies Occupy Fiscal and Household Non-Energy Expenditures?(2020年7月12日)

2022年06月10日

会议视频

Identify the contribution of vehicle non-exhaust emissions: a single particle aerosol mass spectrometer

期刊论文

A conceptual methodology for simultaneous optimization of water and heat with non-isothermal mixing

Yanlong Hou, Wanni Xie, Zhenya Duan, Jingtao Wang

期刊论文

FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA

期刊论文

Effect of non-uniform illumination on performance of solar thermoelectric generators

Ershuai YIN, Qiang LI, Yimin XUAN

期刊论文

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

期刊论文

系统非优分析理论及方法

何平

期刊论文