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YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 343-348 doi: 10.1007/s11705-007-0062-0
关键词: 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer
Tuning porosity of coal-derived activated carbons for CO2 adsorption
《化学科学与工程前沿(英文)》 2022年 第16卷 第9期 页码 1345-1354 doi: 10.1007/s11705-022-2155-1
关键词: coal-derived activated carbons porosity CO2 adsorption molecular dynamics
《医学前沿(英文)》 2023年 第17卷 第3期 页码 534-548 doi: 10.1007/s11684-022-0953-y
关键词: autoimmune hepatitis (AIH) concanavalin A (Con A) human menstrual blood-derived stem cells (MenSCs) apoptosis mitogen-activated protein kinase (MAPK)
Microorganism-derived biological macromolecules for tissue engineering
《医学前沿(英文)》 2022年 第16卷 第3期 页码 358-377 doi: 10.1007/s11684-021-0903-0
关键词: biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 104-110 doi: 10.1007/s11684-016-0432-4
Advances in next-generation sequencing and bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral squamous cell carcinoma (OSCC). Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are required to understand the molecular diversity of cancer and achieve the goal of personalized therapies. Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histological and genetic features of their donor tumors have been shown to be the preferred preclinical tool in translational cancer research compared with other conventional preclinical models. Specifically, genetically well-defined PDX models can be applied to accelerate targeted antitumor drug development and biomarker discovery. Recently, we have successfully established and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancer research. In this paper, we discuss the establishment, characterization, and preclinical applications of the PDX models. In particular, we focus on the classification and applications of the PDX models based on validated annotations, including clinicopathological features, genomic profiles, and pharmacological testing information. We also explore the translational value of this well-annotated PDX panel in the development of co-clinical trials for patient stratification and treatment optimization in the near future. Although various limitations still exist, this preclinical approach should be further tested and improved.
关键词: patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral squamous cell carcinoma
Ultimate bearing capacity of strip footing resting on clay soil mixed with tire-derived aggregates
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 1016-1024 doi: 10.1007/s11709-021-0751-7
关键词: kaolin physical modeling tests stabilization numerical modeling
Fabrication of coconut shell-derived porous carbons for CO adsorption application
《化学科学与工程前沿(英文)》 2023年 第17卷 第8期 页码 1122-1130 doi: 10.1007/s11705-022-2292-6
关键词: porous carbons CO2 adsorption KOH activation single step reaction biomass
Preparation of biomass-derived carbon loaded with MnO as lithium-ion battery anode for improving its
《化学科学与工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11705-023-2376-y
关键词: biomass-derived carbon MnO2 lithium-ion batteries anode material high reversible capacity
Catalytic conversion of biomass-derived compounds to various amino acids: status and perspectives
《化学科学与工程前沿(英文)》 2023年 第17卷 第7期 页码 817-829 doi: 10.1007/s11705-022-2254-z
关键词: biomass amino acids chitin nitrogen-containing compounds lignocellulose
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 426-430 doi: 10.1007/s11684-009-0085-7
关键词: PC-cell-derived growth factor breast neoplasms clinical markers
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 411-415 doi: 10.1007/s11684-012-0226-2
Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patients and tramadol possesses potential antidepressant effects. Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-related kinase B (TrkB) is a high affinity catalytic receptor for BDNF. We hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects with significant changes in hippocampal BDNF and TrkB levels in rats. Immobility time of rats receiving different treatment in the forced swimming test (FST) was observed. Levels of BDNF and TrkB in hippocampus were measured by enzyme linked immunosorbent assay. Results showed that tramadol (5 mg/kg) administrated alone neither elicited antidepressant effects nor altered BDNF or TrkB level. However, pretreatment with tramadol (5 mg/kg) enhanced the ketamine (10 mg/kg) -elicited antidepressant effects and upregulated the BDNF and TrkB levels in hippocampus. In conclusion, tramadol pretreatment reinforces the ketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat hippocampus.
关键词: tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B
《环境科学与工程前沿(英文)》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1672-6
● P-rich carp residues-derived biochars presented excellent Cu sorption capacity.
关键词: Biowaste Pyrolytic temperature Immobilization Bioavailability Remediation
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 447-451 doi: 10.1007/s11684-009-0082-x
关键词: cervical cancer lymphatic vessel density blood vessel density platelet-derived growth factor
A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even
WANG Zhonggao
《医学前沿(英文)》 2008年 第2卷 第2期 页码 127-129 doi: 10.1007/s11684-008-0023-0
关键词: laryngotracheal irritation/spasm gastro-oesophago-laryngo-tracheal sequence fundaplication encouraging
Kaikai Zhang, Peng Sun, Yanrong Zhang
《环境科学与工程前沿(英文)》 2019年 第13卷 第2期 doi: 10.1007/s11783-019-1106-7
PFRs were produced on biochar during Cr(VI) decontamination. PFRs formation on biochar was owing to the oxidization of phenolic-OH by Cr(VI). Appearance of excessive oxidant led to the consumption of PFRs on biochar. Biochar charred at high temperature possessed great performance to Cr(VI) removal.
关键词: Biochar Persistent free radicals Phenolic hydroxyl groups Cr(VI) reduction
标题 作者 时间 类型 操作
Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
期刊论文
Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway
期刊论文
Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research
null
期刊论文
Ultimate bearing capacity of strip footing resting on clay soil mixed with tire-derived aggregates
期刊论文
Preparation of biomass-derived carbon loaded with MnO as lithium-ion battery anode for improving its
期刊论文
Catalytic conversion of biomass-derived compounds to various amino acids: status and perspectives
期刊论文
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
期刊论文
Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic
null
期刊论文
Biochars derived from carp residues: characteristics and copper immobilization performance in water environments
期刊论文
The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
期刊论文
A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even
WANG Zhonggao
期刊论文