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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

《医学前沿（英文）》 2007年 第1卷 第3期   页码 248-252 doi: 10.1007/s11684-007-0047-x

摘要： The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cell migration induced by platelet-derived growth factor (PDGF). Western blot was performed to detect the phosphorylation of p38 in NIH3T3 cells treated with PDGF. A Transwell cell migration system was used to determine the effects of PDGF treatment on the migration of NIH3T3 cells and the influence of deficiency on this process in a gene knockout (p38) mouse embryonic fibroblast cell line. On the stimulation of PDGF, the migration of NIH3T3 cells was significantly increased (〈0.001) compared to the control and p38 MAP kinase was simultaneously phosphorylated. Furthermore, the PDGF-induced cell migration was significantly blocked in gene knockout (p38) mouse embryonic fibroblasts (MEFs) (〈0.001) as compared with the wild type cells (p38). p38 MAPK plays an important role in the regulation of cell migration induced by PDGF.

关键词： control     stimulation     mitogen-activated     growth factor     process    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

《化学科学与工程前沿（英文）》 2012年 第6卷 第2期   页码 232-237 doi: 10.1007/s11705-012-1286-1

摘要： Ninety male Wistar rats were selected under the “Guide for the Care and Use of Laboratory Animals” for skin-muscle wound models. Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogen activated protein kinase) SB 203580 and JNK inhibitor SP 600125, and a control. Light microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascades have modified the formation of the connective tissue scar. The degree of connective tissue growth in the area of surgical wound had been significantly reduced by the end of observation (30 d) as the SB 203580 was applied (% volume of collagen 43.60 (41.05 – 60.15) 73.54 (66.87 – 78.01) in control, = 0.002). Conversely, when we have applied the JNK blocker, the density of collagen in scar tissue increased (78.14 (72.77 – 81.14), = 0.022 control). SB203580 inhibits the expression of p38, c-Jun and c-Fos. When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38 increased. This determines the high functional activity of fibroblasts after using SP 600125. Obtained results show the importance of studying regulators of cell differentiation as potential drugs, which significantly affect the outcome of the pathological processes.

关键词： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via p38MAPK

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

《医学前沿（英文）》 2019年 第13卷 第6期   页码 680-689 doi: 10.1007/s11684-018-0673-5

摘要： Anti- glycoprotein I (anti- GPI) antibodies are important contributors to the development of thrombosis. Anti- GPI antibody complexes with GPI are well known to activate monocytes and endothelial cells via the intracellular NF- B pathway with prothrombotic implications. By contrast, the interaction of anti- GPI/ GPI complexes with platelets has not been extensively studied. The p38 mitogen-activated protein kinase (MAPK) pathway has been recognized to be an important intracellular signaling pathway in the coagulation cascade and an integral component of arterial and venous thrombosis. The present study reveals that levels of anti- GPI/ GPI complexes in sera are positively associated with p38MAPK phosphorylation of platelets in thrombotic patients. Furthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation. Thrombus formation decreased in mice after treatment with anti- GPI/ GPI complexes. In conclusion, p38MAPK may be a treatment target for anti- GPI antibody-associated thrombotic events.

关键词： anti-   

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Biosorption of Direct Black 38 by dried anaerobic granular sludge

WANG Xuejiang, XIA Siqing, ZHAO Jianfu

《环境科学与工程前沿（英文）》 2008年 第2卷 第2期   页码 198-202 doi: 10.1007/s11783-008-0031-y

摘要： The biosorption of Direct Black 38 by dried anaerobic granular sludge in a batch system under specific temperatures and initial pH was investigated. The adsorption reaction is pH dependent with higher removal at low pH. The adsorption equilibrium data fit very well with both Langmuir and Freundlich models in the concentration range of Direct Black 38 at all chosen temperatures. The adsorption parameters show that the adsorption of Direct Black 38 is an endothermic and more effective process at high temperatures. The kinetics of adsorption was found to be second order and adsorption rate constants increased with increasing temperature. Activation energy was determined as 26.8 kJ/mol for the process. This suggests that the adsorption of Direct Black 38 by dried anaerobic granular sludge is chemically controlled.

关键词： Langmuir     kJ/mol     temperature     removal     Freundlich    

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Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 379-383 doi: 10.1007/s11684-009-0073-y

摘要： p38 regulated/activated protein kinase (PRAK) plays a key role in cell senescence and tumor suppression. The aim of this study was to investigate if PRAK had effect on cell proliferation. The growth of and mouse embryonic fibroblast (MEF) cells was measured by methylthiazoletetrazolium (MTT) colorimetric assay, and the proportion of the cell number in different phases of the cell cycle was analyzed by flow cytometry. The growth curves showed that the growth rate was notably decreased, and cell double time was elongated in cells; moreover, the number of cells was decreased by 44.5% compared with that of cells cultured for 96h, suggesting that G/M transition is inhibited in cells. Meanwhile, G/S transition was also inhibited in cells, observed with flow cytometry analysis. The ratios of G/G, G/M, and S phases of cells were 44.9%, 12.2%, and 42.9%, respectively, while those of cells were 55.3%, 7.3%, and 37.4%, respectively. There were 23.1% increase and 12.7% decrease of the number of cells in G and S phases comparison with that of cells, respectively. Taken together, gene knockout in MEF cells leads to cell cycle arrest and proliferation inhibition.

关键词： p38 regulated/activated protein kinase     gene knockout     cell cycle     cell proliferation    

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P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

《能源前沿（英文）》 2023年 第17卷 第2期   页码 189-197 doi: 10.1007/s11708-023-0873-9

摘要： Peer-to-peer (P2P) energy trading is an emerging energy supply paradigm where customers with distributed energy resources (DERs) are allowed to directly trade and share electricity with each other. P2P energy trading can facilitate local power and energy balance, thus being a potential way to manage the rapidly increasing number of DERs in net zero transition. It is of great importance to explore P2P energy trading via public power networks, to which most DERs are connected. Despite the extensive research on P2P energy trading, there has been little large-scale commercial deployment in practice across the world. In this paper, the practical challenges of conducting P2P energy trading via public power networks are identified and presented, based on the analysis of a practical Local Virtual Private Networks (LVPNs) case in North Wales, UK. The ongoing efforts and emerging solutions to tackling the challenges are then summarized and critically reviewed. Finally, the way forward for facilitating P2P energy trading via public power networks is proposed.

关键词： distribution network     local virtual private network     network charges     peer-to-peer (P2P) energy trading     practical implementation.    

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Solomon P Wasser：蕈菌的药用（2019年9月19日）

Solomon P Wasser(高级职称)

2021年01月20日

关键词： 农业科学    

面向服务的P2P网络体系结构层次参考模型研究

刘业,刘林峰,庄艳艳

《中国工程科学》 2007年 第9卷 第9期   页码 72-77

摘要： <p style="text-align: justify;">提出了一种基于交互、 面向服务的P2P网络体系结构框 架模型ISPNA，同时结合P2P网络 松耦合、自组织、可缩放等特点， 对P2P网络技术中增强其可用性需从P2P网络体系结构的研究角度出发， 将增强P2P网络可用性所需要考虑的 多方面因素放置在P2P网络的不同 层次予以解决，有利于从宏观上 把握需要解决的问题。p>

关键词： P2P网络     体系结构     层次参考模型     资源     服务    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

《化学科学与工程前沿（英文）》 2023年 第17卷 第2期   页码 123-138 doi: 10.1007/s11705-022-2194-7

摘要： The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues. NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers. Therefore, it could be a target for cancer therapy. Because it is a quinone reductase, many bioimaging probes based on quinone structures target NAD(P)H:quinone oxidoreductase 1 to diagnose tumours. Its expression is higher in tumours than in normal tissues, and using target drugs such as β-lapachone to reduce side effects in normal tissues can help. However, the physicochemical properties of β-lapachone limit its application. The problem can be solved by using nanosystems to deliver β-lapachone. This mini-review summarizes quinone-based fluorescent, near-infrared and two-photon fluorescent probes, as well as nanosystems for delivering the NAD(P)H:quinone oxidoreductase 1-activating drug β-lapachone. This review provides valuable information for the future development of probes and nano-delivery systems that target NAD(P)H:quinone oxidoreductase 1.

关键词： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

《信息与电子工程前沿（英文）》 2015年 第16卷 第5期   页码 391-403 doi: 10.1631/FITEE.1400267

摘要： The continuous emerging of peer-to-peer (P2P) applications enriches resource sharing by networks, but it also brings about many challenges to network management. Therefore, P2P applications monitoring, in particular, P2P traffic classification, is becoming increasingly important. In this paper, we propose a novel approach for accurate P2P traffic classification at a fine-grained level. Our approach relies only on counting some special flows that are appearing frequently and steadily in the traffic generated by specific P2P applications. In contrast to existing methods, the main contribution of our approach can be summarized as the following two aspects. Firstly, it can achieve a high classification accuracy by exploiting only several generic properties of flows rather than complicated features and sophisticated techniques. Secondly, it can work well even if the classification target is running with other high bandwidth-consuming applications, outperforming most existing host-based approaches, which are incapable of dealing with this situation. We evaluated the performance of our approach on a real-world trace. Experimental results show that P2P applications can be classified with a true positive rate higher than 97.22% and a false positive rate lower than 2.78%.

关键词： Traffic classification     Peer-to-peer (P2P)     Fine-grained     Host-based    

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Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

《中国工程科学》 2014年 第16卷 第1期   页码 59-65

摘要： <p>为满足汽车工业轻量化发展要求，以Q&P（quenching & partitioning）工艺为基础的先进高强度钢受到了广泛关注，为使其在普通热连轧生产线上实现工业化并广泛应用，本文对Q&P理念在热轧工艺中的应用进行了基础研究。结果表明在传统热处理Q&P工艺中引入热变形处理后，组织细化显著，并获得了一定量的残余奥氏体。）&P钢）的可行性。p>

关键词： 先进高强度钢     Q&P     DQ&P     热轧     残余奥氏体    

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UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1379-x

摘要：

• UV-LED with shorter wavelength was beneficial for photocatalytic degradation.

关键词： Degradation     Photocatalytic     LED     CMIT     P25    

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Comparison of modeling methods for wind power prediction: a critical study

Rashmi P. SHETTY, A. SATHYABHAMA, P. Srinivasa PAI

《能源前沿（英文）》 2020年 第14卷 第2期   页码 347-358 doi: 10.1007/s11708-018-0553-3

摘要： Prediction of power generation of a wind turbine is crucial, which calls for accurate and reliable models. In this work, six different models have been developed based on wind power equation, concept of power curve, response surface methodology (RSM) and artificial neural network (ANN), and the results have been compared. To develop the models based on the concept of power curve, the manufacturer’s power curve, and to develop RSM as well as ANN models, the data collected from supervisory control and data acquisition (SCADA) of a 1.5 MW turbine have been used. In addition to wind speed, the air density, blade pitch angle, rotor speed and wind direction have been considered as input variables for RSM and ANN models. Proper selection of input variables and capability of ANN to map input-output relationships have resulted in an accurate model for wind power prediction in comparison to other methods.

关键词： power curve     method of least squares     cubic spline interpolation     response surface methodology     artificial neural network (ANN)    

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noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/

《医学前沿（英文）》   页码 924-938 doi: 10.1007/s11684-023-1004-z

摘要： Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.

关键词： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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标题 作者 时间 类型 操作

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

期刊论文

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

期刊论文

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via p38MAPK

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

期刊论文

Biosorption of Direct Black 38 by dried anaerobic granular sludge

WANG Xuejiang, XIA Siqing, ZHAO Jianfu

期刊论文

Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

期刊论文

construction integration technology in Brazil’s superlarge deep-water offshore oil and gas unit project (FPSO P67/P70)

期刊论文

P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

期刊论文

Solomon P Wasser：蕈菌的药用（2019年9月19日）

Solomon P Wasser(高级职称)

2021年01月20日

会议视频

面向服务的P2P网络体系结构层次参考模型研究

刘业,刘林峰,庄艳艳

期刊论文

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

期刊论文

Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

期刊论文

Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

期刊论文

UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

期刊论文

Comparison of modeling methods for wind power prediction: a critical study

Rashmi P. SHETTY, A. SATHYABHAMA, P. Srinivasa PAI

期刊论文

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/

期刊论文