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Personalized medicine of type 2 diabetes
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《医学前沿（英文）》 2013年 第7卷 第1期 页码 1-3 doi: 10.1007/s11684-013-0241-y
Recent development on statistical methods for personalized medicine discovery
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《医学前沿（英文）》 2013年 第7卷 第1期 页码 102-110 doi: 10.1007/s11684-013-0245-7
It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules using single-stage or multiple-stage clinical data. In this paper, we provide an overview of these methods and list a number of challenges.
关键词： dynamic treatment regimes personalized medicine reinforcement learning Q-learning
Do not let precision medicine be kidnapped
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《医学前沿（英文）》 2015年 第9卷 第4期 页码 512-513 doi: 10.1007/s11684-015-0425-8
Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.
Translational medicine promising personalized therapy in oncology
Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,
《医学前沿（英文）》 2010年 第4卷 第4期 页码 351-355 doi: 10.1007/s11684-010-0320-2
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 337-346 doi: 10.1007/s11684-014-0349-8
Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recognized and adhered by TCM clinical practitioners for thousands of years. However, the underlying mechanisms of TCM personalized medicine are not fully investigated so far and remained unknown. This paper discusses framework of TCM personalized medicine in classic literatures and in real-world clinical settings, and investigates the underlying mechanisms of TCM personalized medicine from the perspectives of network medicine. Based on 246 well-designed outpatient records on insomnia, by evaluating the personal biases of manifestation observation and preferences of herb prescriptions, we noted significant similarities between each herb prescriptions and symptom similarities between each encounters. To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotype network (CPN), in which the clinical phenotype entities like symptoms and diagnoses are presented as nodes and the correlation between these entities as links. This CPN is used to investigate the promiscuous boundary of syndromes and the co-occurrence of symptoms. The small-world topological characteristics are noted in the CPN with high clustering structures, which provide insight on the rationality of TCM personalized diagnosis and treatment. The investigation on this network would help us to gain understanding on the underlying mechanism of TCM personalized medicine and would propose a new perspective for the refinement of the TCM individualized clinical skills.
关键词： personalized medicine complex network clinical phenotype network traditional Chinese medicine
Personalized biomedical devices & systems for healthcare applications
I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM
《机械工程前沿（英文）》 2011年 第6卷 第1期 页码 3-12 doi: 10.1007/s11465-011-0209-z
With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.
关键词： personalized medical devices wearable sensor haptic device ingestible medical capsule
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《医学前沿（英文）》 2016年 第10卷 第1期 页码 104-110 doi: 10.1007/s11684-016-0432-4
Advances in next-generation sequencing and bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral squamous cell carcinoma (OSCC). Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are required to understand the molecular diversity of cancer and achieve the goal of personalized therapies. Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histological and genetic features of their donor tumors have been shown to be the preferred preclinical tool in translational cancer research compared with other conventional preclinical models. Specifically, genetically well-defined PDX models can be applied to accelerate targeted antitumor drug development and biomarker discovery. Recently, we have successfully established and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancer research. In this paper, we discuss the establishment, characterization, and preclinical applications of the PDX models. In particular, we focus on the classification and applications of the PDX models based on validated annotations, including clinicopathological features, genomic profiles, and pharmacological testing information. We also explore the translational value of this well-annotated PDX panel in the development of co-clinical trials for patient stratification and treatment optimization in the near future. Although various limitations still exist, this preclinical approach should be further tested and improved.
关键词： patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral squamous cell carcinoma
Individualized medicine, health medicine, and constitutional theory in Chinese medicine
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《医学前沿（英文）》 2012年 第6卷 第1期 页码 1-7 doi: 10.1007/s11684-012-0173-y
The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.
关键词： individualized medicine health medicine constitutional theory in Chinese medicine
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 272-278 doi: 10.1007/s11684-014-0364-9
Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou
《医学前沿（英文）》 2011年 第5卷 第2期 页码 163-170 doi: 10.1007/s11684-011-0143-9
关键词： Chinese medicine experience medicine evidence-based medicine real world
Clinical research of traditional Chinese medicine in big data era
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 321-327 doi: 10.1007/s11684-014-0370-y
With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.
关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine
Holistic integrative medicine: toward a new era of medical advancement
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《医学前沿（英文）》 2017年 第11卷 第1期 页码 152-159 doi: 10.1007/s11684-017-0499-6
Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine (HIM), which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.
关键词： holistic integrative medicine precision medicine general practice medicine
符友丰
《中国工程科学》 2006年 第8卷 第9期 页码 1-12
以疫病流行及其原型分析为线索，联系早期治法（如热熨、火灸、砭刺等）探讨了古代以腺鼠疫为代表的疫病流行与医学起源间的内在联系；以医源于疫的视野分析我国医史病史研究在出土文物、古文字和医学文献等方面丰富的信息资源与优势；分析解读疾病名实的古今变迁、比较中西医学及其在认识论与方法论上的差异，为审视我国传统医学在疫病防治方面的丰富经验与延至今日的独到成就与意义，疾病史研究成果与推广，实现古为今用，将为当今疫病防治的中西互补、中西医结合与比较提供宝贵的历史经验与借鉴。
Jian Wang, Wen Zou
《医学前沿（英文）》 2011年 第5卷 第2期 页码 123-126 doi: 10.1007/s11684-011-0124-z
Traditional Chinese medicine in the new century
Jianxiang Liu, Zhu Chen
《医学前沿（英文）》 2011年 第5卷 第2期 页码 111-114 doi: 10.1007/s11684-011-0125-y
标题 作者 时间 类型 操作
Translational medicine promising personalized therapy in oncology
Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,
期刊论文
Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditionalChinese medicine
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期刊论文
Personalized biomedical devices & systems for healthcare applications
I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM
期刊论文
Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization
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期刊论文
Utilizing big data to build personalized technology and system of diagnosis and treatment in traditionalChinese medicine
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期刊论文
Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine
Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou
期刊论文
Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China
Jian Wang, Wen Zou
期刊论文
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