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期刊论文 2

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2012 1

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Comparative lipidomic analysis of

Bin QIAO, Hong-Chi TIAN, Ying-Jin YUAN

《化学科学与工程前沿(英文)》 2012年 第6卷 第4期   页码 461-469 doi: 10.1007/s11705-012-1223-3

摘要: Variations in the composition and level of phospholipids (PLs) in yeast cells during industrial ethanol fermentation processes were analyzed. A comparative lipidomic method was used to investigate the changes in total cellular PLs during continuous and fed-batch/batch processes. The phospholipid metabolism in yeast changed during both processes, mainly due to the presence of long-chain poly unsaturated fatty acids (PUFA) that contained phosphatidyglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylserine (PS). The complexity of the media affected the growth of the yeast and the membrane composition. Yeast incorporated lots of exogenous saturated and PUFAs from the feedstock during the fermentations. During the continuous fermentation, there was an increase in PLs with shorter chains as the fermentation progressed and early in process there were more long-chains. During the fed-batch/batch process, the PG species increased as the fermentation progressed. This is probably due to an inositol deficiency in the earlier part of the fermentation.

关键词: lipidomics     systems biology     phospholipids     stirred-tank     saccharomyces cerevisiae     biorefinery engineering    

Dietary Lipid Intervention in the Prevention of Brain Aging

Wei Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Min Du,Jiazeng Sun,Juan Chen,Yixuan Li,Changhao Sun,Xingen Lei,Xue Zhang,Fazheng Ren,

《工程(英文)》 doi: 10.1016/j.eng.2023.04.012

摘要: As people live longer, the burden of aging-related brain diseases, especially dementia, is increasing. Brain aging increases the risk of cognitive impairment, which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid homeostasis. Therefore, supplemental dietary lipids have the potential to prevent brain aging. This review summarizes the important roles of dietary lipids in brain function from both structure and mechanism perspectives. Epidemiological and animal studies have provided evidence of the functions of polyunsaturated fatty acids (PUFAs) in brain health. The results of interventions indicate that phospholipids—including phosphatidylcholine, phosphatidylserine, and plasmalogen—are efficient in alleviating cognitive impairment during aging, with plasmalogen exhibiting higher efficacy than phosphatidylserine. Plasmalogen is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of neurons. Future research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

关键词: Brain aging     Nutritional intervention     Phospholipids     Phosphatidylcholine     Phosphatidylserine     Plasmalogen    

标题 作者 时间 类型 操作

Comparative lipidomic analysis of

Bin QIAO, Hong-Chi TIAN, Ying-Jin YUAN

期刊论文

Dietary Lipid Intervention in the Prevention of Brain Aging

Wei Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Min Du,Jiazeng Sun,Juan Chen,Yixuan Li,Changhao Sun,Xingen Lei,Xue Zhang,Fazheng Ren,

期刊论文