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Do not let precision medicine be kidnapped

null

《医学前沿（英文）》 2015年第9卷第4期页码 512-513 doi: 10.1007/s11684-015-0425-8

摘要：

Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

关键词： precision medicine personalized medicine genomics

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

《机械工程前沿（英文）》 2017年第12卷第2期页码 158-180 doi: 10.1007/s11465-017-0455-9

摘要：

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracy and surface quality. As more research findings are published, such technologies now involve complicated systems engineering and been widely used in the production of components in various aerospace, national defense, optics, mechanics, electronics, and other high-tech applications. The conception, applications and history of ultra-precision machining are introduced in this article, and the developments of ultra-precision machining technologies, especially ultra-precision grinding, ultra-precision cutting and polishing are also reviewed. The current state and problems of this field in China are analyzed. Finally, the development trends of this field and the coping strategies employed in China to keep up with the trends are discussed.

关键词： ultra-precision grinding ultra-precision cutting ultra-precision polishing research status in China development tendency

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Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

《机械工程前沿（英文）》 2008年第3卷第3期页码 348-353 doi: 10.1007/s11465-008-0065-7

摘要： This paper presents the principle of self-generation of machining precision by explaining its basic concept and five necessary conditions for forming a system with self-organization capability. A self-generation system is a kind of system with self-organization capability. The self-generation of machining precision for solid balls with super precision is emphatically explained. From the viewpoint of self-organization, there are three types of systems including system 1 with the self-regulation capability, 2 with the self-determination capability of goals, and 3 with the self-organization capability. Although they are all closed loop control systems, they have different constructions and functions. Necessary conditions for achieving self-generation of machining precision are given. Establishment of the system for machining solid balls with super precision is discussed. Self-generation of machining precision for solid balls with super precision on the basis of the capability of self-removal of errors is presented. Self-generation includes the ability of self-removal of errors for solid balls, convergence of self-removal of errors, self-generation of precision, and self-generating system for the given.

关键词： self-generation necessary self-regulation capability viewpoint Necessary

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Human pangenome: far-reaching implications in precision medicine

《医学前沿（英文）》 doi: 10.1007/s11684-023-1039-1

摘要： Human pangenome: far-reaching implications in precision medicine

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Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

《农业科学与工程前沿（英文）》 2018年第5卷第4期页码 391-392 doi: 10.15302/J-FASE-2018246

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High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

《农业科学与工程前沿（英文）》 2018年第5卷第4期页码 393-405 doi: 10.15302/J-FASE-2018226

摘要：

The central concept of precision agriculture is to manage within-field soil and crop growth variability for more efficient use of farming inputs. Remote sensing has been an integral part of precision agriculture since the farming technology started developing in the mid to late 1980s. Various types of remote sensors carried on ground-based platforms, manned aircraft, satellites, and more recently, unmanned aircraft have been used for precision agriculture applications. Original satellite sensors, such as Landsat and SPOT, have commonly been used for agricultural applications over large geographic areas since the 1970s, but they have limited use for precision agriculture because of their relatively coarse spatial resolution and long revisit time. Recent developments in high resolution satellite sensors have significantly narrowed the gap in spatial resolution between satellite imagery and airborne imagery. Since the first high resolution satellite sensor IKONOS was launched in 1999, numerous commercial high resolution satellite sensors have become available. These imaging sensors not only provide images with high spatial resolution, but can also repeatedly view the same target area. The high revisit frequency and fast data turnaround time, combined with their relatively large aerial coverage, make high resolution satellite sensors attractive for many applications, including precision agriculture. This article will provide an overview of commercially available high resolution satellite sensors that have been used or have potential for precision agriculture. The applications of these sensors for precision agriculture are reviewed and application examples based on the studies conducted by the author and his collaborators are provided to illustrate how high resolution satellite imagery has been used for crop identification, crop yield variability mapping and pest management. Some challenges and future directions on the use of high resolution satellite sensors and other types of remote sensors for precision agriculture are discussed.

关键词： high resolution satellite sensor multispectral imagery precision agriculture spatial resolution temporal resolution

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

null

《医学前沿（英文）》 2018年第12卷第2期页码 229-235 doi: 10.1007/s11684-017-0581-0

摘要：

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

关键词： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

《医学前沿（英文）》 2019年第13卷第5期页码 540-546 doi: 10.1007/s11684-018-0637-9

摘要： Given the rapid development in precision medicine, tremendous efforts have been devoted to discovering new biomarkers for disease diagnosis and treatment. Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor gene, is emerging as a sentinel molecule for gauging tissue homeostasis. ECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expression pattern. The gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precision medicine. This review provides an updated summary on the biology of ECRG4, with emphasis on its important roles in cancer diagnosis and therapy. The future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed in detail.

关键词： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

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Application of liquid biopsy in precision medicine: opportunities and challenges

null

《医学前沿（英文）》 2017年第11卷第4期页码 522-527 doi: 10.1007/s11684-017-0526-7

摘要：

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could serve as liquid biopsy, which would be useful for numerous diagnostic applications. Liquid biopsies can help clinicians screen and detect cancer early, stratify patients to the most suitable treatment and real-time monitoring of treatment response and resistance mechanisms in the tumor, evaluate the risk for metastatic relapse, and estimate prognosis. We summarized the advantages and disadvantages of tissue and liquid biopsies. We also further compared and analyzed the advantages and limitations of detecting CTCs, ctDNAs, and exosomes. Furthermore, we reviewed the literature related with the application of serum or plasma CTCs, ctDNAs, and exosomes for diagnosis and prognosis of cancer. We also analyzed their opportunities and challenges as future biomarkers. In the future, liquid biopsies could be used to guide cancer treatment. They could also provide the ideal scheme to personalize treatment in precision medicine.

关键词： liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine

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Special issue: Ultra-precision machining

Zhuangde JIANG,Dongming GUO

《机械工程前沿（英文）》 2017年第12卷第1期页码 1-2 doi: 10.1007/s11465-017-0445-y

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Development and application prospects of piezoelectric precision driving technology

ZHAO Chunsheng, ZHANG Jiantao, ZHANG Jianhui, JIN Jiamei

《机械工程前沿（英文）》 2008年第3卷第2期页码 119-132 doi: 10.1007/s11465-008-0034-1

摘要： With the rapid development of science and technology, microelectronics manufacturing, photonics technology, space technology, ultra-precision machining, micro-robotics, biomedical engineering and other fields urgently need the support of modern precision driving theory and technology. Modern precision driving technology can be generally divided into two parts: electromagnetic and non-electromagnetic driving technology. Electromagnetic driving technology is based on traditional technology, has a low thrust-weight ratio, and needs deceleration devices with a cumbrous system or a complex structure. Moreover, it is difficult to improve positioning accuracy with this technology type. Thus, electromagnetic driving technology is still unable to meet the requirements for the above applications. Non-electromagnetic driving technology is a new choice. As a category of non-electromagnetic driving technology, piezoelectric driving technology becomes an important branch of modern precision driving technology. High holding torque and acute response make it suitable as an accurate positioning actuator. This paper presents the development of piezoelectric precision driving technology at home and abroad and gives an in-depth analysis. Future perspectives on the technology’s applications in the following fields are described: 1) integrated circuit manufacturing technology; 2) fiber optic component manufacturing technology; 3) micro parts manipulation and assembly technology; 4) biomedical engineering; 5) aerospace technology; and 6) ultra-precision processing technology.

关键词： Electromagnetic ultra-precision processing technology piezoelectric cumbrous

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Research progress on ultra-precision machining technologies for soft-brittle crystal materials

Hang GAO,Xu WANG,Dongming GUO,Yuchuan CHEN

《机械工程前沿（英文）》 2017年第12卷第1期页码 77-88 doi: 10.1007/s11465-017-0411-8

摘要：

Soft-brittle crystal materials are widely used in many fields, especially optics and microelectronics. However, these materials are difficult to machine through traditional machining methods because of their brittle, soft, and anisotropic nature. In this article, the characteristics and machining difficulties of soft-brittle and crystals are presented. Moreover, the latest research progress of novel machining technologies and their applications for soft-brittle crystals are introduced by using some representative materials (e.g., potassium dihydrogen phosphate (KDP), cadmium zinc telluride (CZT)) as examples. This article reviews the research progress of soft-brittle crystals processing.

关键词： brittle soft functional crystal ultra-precision machining

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A hybrid deep learning model for robust prediction of the dimensional accuracy in precision milling of

《机械工程前沿（英文）》 2022年第17卷第3期 doi: 10.1007/s11465-022-0688-0

摘要： The use of artificial intelligence to process sensor data and predict the dimensional accuracy of machined parts is of great interest to the manufacturing community and can facilitate the intelligent production of many key engineering components. In this study, we develop a predictive model of the dimensional accuracy for precision milling of thin-walled structural components. The aim is to classify three typical features of a structural component—squares, slots, and holes—into various categories based on their dimensional errors (i.e., “high precision,” “pass,” and “unqualified”). Two different types of classification schemes have been considered in this study: those that perform feature extraction by using the convolutional neural networks and those based on an explicit feature extraction procedure. The classification accuracy of the popular machine learning methods has been evaluated in comparison with the proposed deep learning model. Based on the experimental data collected during the milling experiments, the proposed model proved to be capable of predicting dimensional accuracy using cutting parameters (i.e., “static features”) and cutting-force data (i.e., “dynamic features”). The average classification accuracy obtained using the proposed deep learning model was 9.55% higher than the best machine learning algorithm considered in this paper. Moreover, the robustness of the hybrid model has been studied by considering the white Gaussian and coherent noises. Hence, the proposed hybrid model provides an efficient way of fusing different sources of process data and can be adopted for prediction of the machining quality in noisy environments.

关键词： precision milling dimensional accuracy cutting force convolutional neural networks coherent noise

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Gray-box modeling and QFT control for precision servo transmission systems

Xiulan BAO, Xuedong CHEN, Xin LUO, Haocheng ZUO

《机械工程前沿（英文）》 2011年第6卷第4期页码 442-448 doi: 10.1007/s11465-011-0242-y

摘要：

Precision servo transmission systems have widely been applied in industrial equipment to achieve high accuracy and high speed motion. However, due to the presence of friction and uncertainty, the characteristics of precision servo transmission systems are variant depends on the working conditions, leading to oscillation and instability in the system performances. In this paper, a grey-box model of the system is established, the model structure derived from the theoretical modeling and the model parameters are obtained by experiments using set membership identification method. This paper proposes two-degrees of freedom (2-DOF) robust position controller for a precision servo transmission system, based on the quantitative feedback theory (QFT), to achieve high accuracy and consistent tracking performance even in presence of considerable system uncertainties and friction disturbances. The results of simulate and experiment validate the effectiveness of the proposed controller.

关键词： precision servo transmission system modeling set membership identification quantitative feedback theory (QFT) robustness

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Improving retrieval precision of NO

Jinpeng YANG

《机械工程前沿（英文）》 2009年第4卷第1期页码 92-96 doi: 10.1007/s11465-009-0001-5

摘要： The NO density error retrieved by the traditional method of differential optical absorption spectroscopy (DOAS) was analyzed. The technique for reducing the error is proposed and used to obtain the NO density of Chengdu through DOAS.

关键词： absorption structure low-frequency structure absorption cross-section NO₂ density