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Evaluation of power regeneration in primary suspension for a railway vehicle

Ruichen WANG, Zhiwei WANG

《机械工程前沿(英文)》 2020年 第15卷 第2期   页码 265-278 doi: 10.1007/s11465-019-0571-9

摘要: To improve the fuel economy of rail vehicles, this study presents the feasibility of using power regenerating dampers (PRDs) in the primary suspension systems of railway vehicles and evaluates the potential and recoverable power that can be obtained. PRDs are configured as hydraulic electromagnetic-based railway primary vertical dampers and evaluated in parallel and series modes (with and without a viscous damper). Hydraulic configuration converts the linear behavior of the track into a unidirectional rotation of the generator, and the electromagnetic configuration provides a controllable damping force to the primary suspension system. In several case studies, generic railway vehicle primary suspension systems that are configured to include a PRD in the two configuration modes are modeled using computer simulations. The simulations are performed on measured tracks with typical irregularities for a generic UK passenger route. The performance of the modified vehicle is evaluated with respect to key performance indicators, including regenerated power, ride comfort, and running safety. Results indicate that PRDs can simultaneously replace conventional primary vertical dampers, regenerate power, and exhibit desirable dynamic performance. A peak power efficiency of 79.87% is theoretically obtained in series mode on a top-quality German Intercity Express track (Track 270) at a vehicle speed of 160 mile/h (~257 km/h).

关键词: railway vehicle     primary damper     power regeneration     ride comfort     running safety    

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

《医学前沿(英文)》   页码 957-971 doi: 10.1007/s11684-023-0988-8

摘要: Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms. Although nearly 50 causative genes have been identified, they only account for approximately 70% of definitive PCD cases. Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain in motile cilia and sperm flagella. Based on the common axoneme structure of motile cilia and sperm flagella, DNAH10 variants are likely to cause PCD. Using exome sequencing, we identified a novel DNAH10 homozygous variant (c.589C > T, p.R197W) in a patient with PCD from a consanguineous family. The patient manifested sinusitis, bronchiectasis, situs inversus, and asthenoteratozoospermia. Immunostaining analysis showed the absence of DNAH10 and DNALI1 in the respiratory cilia, and transmission electron microscopy revealed strikingly disordered axoneme 9+2 architecture and inner dynein arm defects in the respiratory cilia and sperm flagella. Subsequently, animal models of Dnah10-knockin mice harboring missense variants and Dnah10-knockout mice recapitulated the phenotypes of PCD, including chronic respiratory infection, male infertility, and hydrocephalus. To the best of our knowledge, this study is the first to report DNAH10 deficiency related to PCD in human and mouse models, which suggests that DNAH10 recessive mutation is causative of PCD.

关键词: DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

Approach for natural gas to be a primary energy source in China

Weihe HUANG, Jindian CHEN, Chuan FU, Yan HUANG

《工程管理前沿(英文)》 2019年 第6卷 第4期   页码 467-476 doi: 10.1007/s42524-019-0068-6

摘要: This work reveals the positioning of natural gas in the evolution of world energy and the general law of its development. In the long-term adjustment of energy structure, natural gas has gradually become the primary energy source because of five factors: policy, resources, technology, facilities, and market. To expedite the revolution of energy production and consumption, China must urgently expand the use of natural gas toward a more positive role in complementing coal and renewable energy and prioritize its usage in three areas, namely, urban gas, power generation, and industrial fuel. Natural gas is expected to account for approximately 15% of China’s total energy consumption in the future. For natural gas to be the primary energy, the exploitation of gas resources must be expanded, resource access must be improved, a flexible trade system must be set up, infrastructure investment must be increased, and the security system must be enhanced.

关键词: natural gas     energy revolution     primary energy     utilization areas     approaching means    

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

null

《医学前沿(英文)》 2017年 第11卷 第2期   页码 191-202 doi: 10.1007/s11684-017-0512-0

摘要:

Primary hepatic carcinoma (PHC) is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine (TCM). TCM has been widely used to improve the quality of life, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials (RCTs) involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.

关键词: traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

Tuning the primary selective nanochannels of MOF thin-film nanocomposite nanofiltration membranes for

《环境科学与工程前沿(英文)》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1474-7

摘要:

• PA layer properties tune the primary nanochannels in MIL-101(Cr) TFN NF membranes.

关键词: Porous metal organic framework     Thin-film nanocomposite membrane     Primary selective nanochannels     Nanofiltration     Endocrine disrupting compounds    

Primary hypertrophic osteoarthropathy: an update

null

《医学前沿(英文)》 2013年 第7卷 第1期   页码 60-64 doi: 10.1007/s11684-013-0246-6

摘要:

Digital clubbing, which has been recognized as a sign of systemic disease, is one of the most ancient diseases. However, the pathogenesis of clubbing and hypertrophic osteoarthropathy has hitherto been poorly understood. The study of a clinically indistinguishable idiopathic form (primary hypertrophic osteoarthropathy, PHO) provides an opportunity to understand the pathogenesis of hypertrophic osteoarthropathy. Current advances in the study of PHO are discussed. The impaired metabolism of prostaglandin E2 (PGE2) plays a central role in its pathogenesis.

关键词: digital clubbing     primary hypertrophic osteoarthropathy     prostaglandin E2 (PGE2)    

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

《医学前沿(英文)》 2021年 第15卷 第6期   页码 933-937 doi: 10.1007/s11684-021-0860-7

摘要: Neurofibromatosis (NF) is a genetic disease in which the lungs are rarely involved. However, in NF cases with lung involvement, chest computed tomography may show bilateral basal reticulations, apical bullae, and cysts without bronchiectasis. Herein, we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and bronchiectasis. Considering the differential diagnosis of bronchiectasis combined with his early-onset wet cough, sinusitis, and sperm quality decline, we considered the possibility of primary ciliary dyskinesia (PCD). Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of PCD. Therefore, for patients with NF, when an image change exists in the lungs that does not correspond to NF, the possibility of other diagnoses, including PCD, must be considered.

关键词: primary ciliary dyskinesia     neurofibromatosis     bronchiectasis     transmission electron microscopy     genetic sequencing    

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

《医学前沿(英文)》 2008年 第2卷 第1期   页码 11-14 doi: 10.1007/s11684-008-0003-4

摘要: Using the plasma aldosterone concentration to plasma renin activity ratio (PAC/PRA ratio) as the screening test of choice for primary aldosteronism in hypertensive patients, we studied the clinical characteristics and the diagnostic value of PAC/PRA ratio in primary aldosteronism. The plasma aldosterone concentration (PAC) and plasma renin activity (PRA) levels were measured by radioimmunoassay in 902 hypertensive patients from out-patient clinics or hospitals. One hundred and twenty-six suspected primary aldosteronism patients whose PAC/PRA ratio was > 25 ng/dL/ng/mL/hr had a lamellar computed tomography (CT) scan in the adrenal gland and follow-up visits. The proportion of primary aldosteronism in hypertensive patients was 14% (126/902). There were 54 patients with unilateral or bilateral hyperplasia and 25 patients with adenoma according to the CT scan. 39% (49/126) of the patients with primary aldosteronism had hypokalemia. Twenty-five patients received surgical treatment. The efficacy and cure rates were 100% (25/25) and 48% (12/25), respectively. The effective rate of aldactone and the single-drug cure rate were 89% (48/54) and 24% (13/54), respectively. Primary aldosteronism affects over 10% of hypertensive patients in China. The PAC/PRA ratio can be considered as a routine screening test in hypertensives, especially resistant hypertensive patients and a high PAC/PRA ratio is an invaluable index in primary aldosteronism diagnosis.

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

《医学前沿(英文)》 doi: 10.1007/s11684-023-0997-7

摘要: Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54, the homolog of CFAP54 in Chlamydomonas reinhardtii, was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella. A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes. Through whole-exome sequencing, compound heterozygous variants c.2649_2657delinC (p. E883Dfs*47) and c.7312_7313insCGCAGGCTGAATTCTTGG (p. T2438delinsTQAEFLA) in a new suspected PCD-relevant gene, CFAP54, were identified in an individual with PCD. Two missense variants, c.4112A>C (p. E1371A) and c.6559C>T (p. P2187S), in CFAP54 were detected in another unrelated patient. In this study, a minigene assay was conducted on the frameshift mutation showing a reduction in mRNA expression. In addition, a CFAP54 in-frame variant knock-in mouse model was established, which recapitulated the typical symptoms of PCD, including hydrocephalus, infertility, and mucus accumulation in nasal sinuses. Correspondingly, two missense variants were deleterious, with a dramatic reduction in mRNA abundance from bronchial tissue and sperm. The identification of PCD-causing variants of CFAP54 in two unrelated patients with PCD for the first time provides strong supportive evidence that CFAP54 is a new PCD-causing gene. This study further helps expand the disease-associated gene spectrum and improve genetic testing for PCD diagnosis in the future.

关键词: primary ciliary dyskinesia     CFAP54     cilia    

Health: a dream from reality to the future

null

《医学前沿(英文)》 2016年 第10卷 第2期   页码 233-235 doi: 10.1007/s11684-016-0444-0

摘要:

This paper argues that health is a realistic productive force that may enhance the index of happiness. As the basis of all developments and the source of a person’s and his/her family’s happiness, health requires not only primary and secondary prevention, but also policy prevention, that is to say, grade-zero prevention. Therefore, people should pay more attention to Health in All Policies. As a new preventive strategy, the policy prevention will help improve people’s health significantly and promote the concepts of “Healthy China” and “the Chinese Dream” or “the World Dream” to realize a dream from reality to the future.

关键词: health promotion     primary and secondary prevention     policy prevention     infectious disease     non-communicable disease    

Primary cilia in hard tissue development and diseases

《医学前沿(英文)》 2021年 第15卷 第5期   页码 657-678 doi: 10.1007/s11684-021-0829-6

摘要: Bone and teeth are hard tissues. Hard tissue diseases have a serious effect on human survival and quality of life. Primary cilia are protrusions on the surfaces of cells. As antennas, they are distributed on the membrane surfaces of almost all mammalian cell types and participate in the development of organs and the maintenance of homeostasis. Mutations in cilium-related genes result in a variety of developmental and even lethal diseases. Patients with multiple ciliary gene mutations present overt changes in the skeletal system, suggesting that primary cilia are involved in hard tissue development and reconstruction. Furthermore, primary cilia act as sensors of external stimuli and regulate bone homeostasis. Specifically, substances are trafficked through primary cilia by intraflagellar transport, which affects key signaling pathways during hard tissue development. In this review, we summarize the roles of primary cilia in long bone development and remodeling from two perspectives: primary cilia signaling and sensory mechanisms. In addition, the cilium-related diseases of hard tissue and the manifestations of mutant cilia in the skeleton and teeth are described. We believe that all the findings will help with the intervention and treatment of related hard tissue genetic diseases.

关键词: primary cilia     bone     mechanical sensing     hard tissue     cilium-related bone disease     tooth    

β-Cyclodextrin promoted oxidation of primary amines to nitriles in water

Dongpo SHI, Hongbing JI, Zhong LI

《化学科学与工程前沿(英文)》 2009年 第3卷 第2期   页码 196-200 doi: 10.1007/s11705-009-0051-6

摘要: A facile, efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by cyclodextrin ( CD) has been developed in water for the first time, and the behavior of cyclodextrin that catalyzed the primary amines to nitriles in water was investigated. It was found that the primary amines which could form host-guest complexes with cyclodextrin were oxidized to nitriles with excellent yields at ambient temperature. The results show that cyclodextrin worked not only as a solubilizing agent but also as a catalyst in these reactions.

关键词: substrate-selective     amines oxidation     β-cyclodextrin    

System construction of a four-side primary permanent-magnet linear motor drive mechanical press

Jintao LIANG, Zhengfeng MING, Peida LI

《机械工程前沿(英文)》 2020年 第15卷 第4期   页码 600-609 doi: 10.1007/s11465-020-0597-z

摘要: A primary permanent-magnet linear motor (PPMLM) has a robust secondary structure and high force density and is appropriate for direct-drive mechanical press. The structure of a four-side PPMLM drive press is presented based on our previous research. The entire press control system is constructed to realize various flexible forming processes. The control system scheme is determined in accordance with the mathematical model of PPMLM, and active disturbance rejection control is implemented in the servo controller. Field-circuit coupling simulation is applied to estimate the system’s performance. Then, a press prototype with 6 kN nominal force is fabricated, and the hardware platform of the control system is constructed for experimental study. Punch strokes with 0.06 m displacement are implemented at trapezoidal speeds of 0.1 and 0.2 m/s; the dynamic position tracking errors are less than 0.45 and 0.82 mm, respectively. Afterward, continuous reciprocating strokes are performed, and the positioning errors at the bottom dead center are less than 0.015 mm. Complex pulse trajectories are also achieved. The proposed PPMLM drive press exhibits a fast dynamic response and favorable tracking precision and is suitable for various forming processes.

关键词: mechanical press     direct drive     primary permanent-magnet linear motor (PPMLM)     servo system     active disturbance rejection control (ADRC)     prototype experiment    

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

《医学前沿(英文)》 2007年 第1卷 第1期   页码 109-114 doi: 10.1007/s11684-007-0021-7

摘要: The overall diagnostic capabilities and utility of frequency-doubling technology (FDT) in patients with primary glaucoma, which was diagnosed by standard automated perimetry (SAP) and/or optic disc appearance as the gold standard, were assessed. A comprehensive electric retrieval in MEDLINE, EMBASE, Cochrane Library, BIOSIS, Previews, HMIC, IPA, OVID, CNKI, CBMdisc, VIP information, CMCC, CCPD, SSreader, 21dmedia and manual retrieval in related textbooks, journals, congress articles and their references at home and abroad were performed to identify relevant articles in English or Chinese. The corresponding references were retrieved by means of electric retrieval and manual retrieval from different databases or materials. Criteria for inclusion or exclusion were established according to validity criteria for diagnostic studies published by the Cochrane Methods Group on Screening and Diagnostic Tests. The quality of the included articles was then assessed and characteristics were extracted. Statistical analysis was performed with Meta Test version 0.6 software to test the heterogeneity of the included articles. The appropriate effects model was selected to calculate pooled weighted sensitivity and specificity. Summary receiver operating characteristic (SROC) curve was drawn and the area under the curve (AUC) was calculated. Finally, sensitivity analysis was performed. Twenty-one studies out of 206 retrieved articles were included, with a total of 3172 patients. The reported sensitivity of FDT ranged from 0.51 to 1.00, and specificity from 0.58 to 1.00. The pooled weighted sensitivity and specificity of FDT with 95% confidence intervals (95% CI) after correction for standard error were 0.86 (0.80 0.90) and 0.87 (0.81 0.91), respectively. The AUC of SROC was 93.01%. Sensitivity analysis demonstrated no disproportionate influences of individual studies. The included articles are of good quality and FDT can be a highly efficient diagnostic test for primary glaucoma based on Meta-analysis.

关键词: inclusion     sensitivity analysis     correction     specificity     appropriate    

Primary nucleation of lithium carbonate

Yuzhu SUN, Xingfu SONG, Jin WANG, Yan LUO, Jianguo YU

《化学科学与工程前沿(英文)》 2009年 第3卷 第1期   页码 73-77 doi: 10.1007/s11705-009-0091-y

摘要: A set of laser apparatus was used to explore the induction period and the primary nucleation of lithium carbonate. Results show that the induction period increases with the decrease of supersaturation, temperature and stirring speed. Through the classical theory of primary nucleation, many important properties involved in primary nucleation under different conditions were obtained quantitatively, including the interfacial tension between solid and liquid, contact angle, critical nucleus size, critical nuleation free energy etc.

关键词: lithium carbonate     primary nucleation     reactive crystallization     induction period    

标题 作者 时间 类型 操作

Evaluation of power regeneration in primary suspension for a railway vehicle

Ruichen WANG, Zhiwei WANG

期刊论文

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

期刊论文

Approach for natural gas to be a primary energy source in China

Weihe HUANG, Jindian CHEN, Chuan FU, Yan HUANG

期刊论文

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

null

期刊论文

Tuning the primary selective nanochannels of MOF thin-film nanocomposite nanofiltration membranes for

期刊论文

Primary hypertrophic osteoarthropathy: an update

null

期刊论文

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

期刊论文

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

期刊论文

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

期刊论文

Health: a dream from reality to the future

null

期刊论文

Primary cilia in hard tissue development and diseases

期刊论文

β-Cyclodextrin promoted oxidation of primary amines to nitriles in water

Dongpo SHI, Hongbing JI, Zhong LI

期刊论文

System construction of a four-side primary permanent-magnet linear motor drive mechanical press

Jintao LIANG, Zhengfeng MING, Peida LI

期刊论文

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

期刊论文

Primary nucleation of lithium carbonate

Yuzhu SUN, Xingfu SONG, Jin WANG, Yan LUO, Jianguo YU

期刊论文