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期刊论文 5

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2016 2

2014 1

2012 1

2007 1

关键词

PIC16F877A 1

RS—485总线 1

Reed-Solomon码；步进式译码算法；超宽带；流水线架构 1

dsPIC30F4012 1

光纤通信 1

漏电保护 1

选择性 1

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk

null

《医学前沿（英文）》 2014年 第8卷 第2期   页码 217-226 doi: 10.1007/s11684-014-0326-2

摘要：

This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk of hepatocellular carcinoma (HCC). A total of 1021 healthy controls, 302 HBV surface antigen (HBsAg) seroclearance subjects, and 2011 HBsAg-positive subjects (including 1021 HCC patients) were enrolled in this study. Quantitative PCR was used to genotype rs3783553. HBV mutations were determined by direct sequencing. Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations, and their interactions with the risk of HCC. No significant association was found between rs3783553 and the risk of HCC among healthy controls, HBsAg seroclearance subjects, HBsAg-positive subjects without HCC, and all controls. Additionally, rs3783553 was not significantly associated with chronic HBV infection, liver cirrhosis, HBV e antigen seroconversion, abnormal alanine aminotransferase, and high viral load (>104 copies/ml). However, the TTCA insertion allele of rs3783553 was significantly associated with an increased frequency of HBV C7A mutation compared with homozygous TTCA deletion carriers [(del/ins+ ins/ins) vs. del/del, adjusted odds ratio (OR)=1.48, 95% confidence interval (CI)=1.09-2.02, P=0.013]. Multiplicative interaction of rs3783553 with HBV preS deletion significantly reduced the risk of HCC in males, with an adjusted OR of 0.64 (95% CI=0.42-0.98; P=0.041) after age and HBV genotype were adjusted. Although rs3783553 did not significantly affect genetic susceptibility to HBV-related HCC, its variant allele may predispose the host to selecting HBV C7A mutation during evolution and significantly reduce the risk of HCC caused by HBV preS deletion. This study provides an insight into the complex host-virus interaction in HBV-induced hepatocarcinogenesis and is helpful in determining HBsAg-positive subjects who are likely to develop HCC.

关键词： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (HBV) mutations    

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Genetic variation of carotenoids in Chinese bread wheat cultivars and the effect of the 1BL.1RS translocation

Wenshuang LI,Shengnan ZHAI,Hui JIN,Weie WEN,Jindong LIU,Xianchun XIA,Zhonghu HE

《农业科学与工程前沿（英文）》 2016年 第3卷 第2期   页码 124-130 doi: 10.15302/J-FASE-2016094

摘要： Carotenoid content of wheat is an important criterion for prediction of the commercial and nutritional value of products made from bread wheat ( ) cultivars. The objective of this study was to determine the major components of carotenoids in Chinese wheat using ultra performance liquid chromatography (UPLC) including lutein, zeaxanthin, α-carotene and β-carotene. Grain carotenoid content was investigated in 217 cultivars from three major Chinese wheat regions and from seven other countries grown in two environments. Genotype contributed to the majority of variation in carotenoid components. Lutein, zeaxanthin and β-carotene concentrations varied from 18.3 to 100.1, 4.9 to 12.0 and 0.9 to 48.7 μg per 100 g in wheat flour with an average of 40.2, 7.2 and 18.2 μg per 100 g, respectively. Lutein (61.3%) was the main carotenoid component, followed by β-carotene (27.7%) and zeaxanthin (11.0%). No α-carotene was detected. Total carotenoids, lutein, zeaxanthin and β-carotene were all higher in cultivars with the 1BL.1RS translocation compared to those without the translocation. This is the first report on assay of lutein, zeaxanthin and β-carotene concentrations for a large number of wheat cultivars. These data will be useful for genetic improvement of wheat carotenoid content and for understanding of the carotenoid biosynthetic pathway in wheat.

关键词： Triticum aestivum     carotenoids     nutritional quality     UPLC    

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矿井低压电网选择性漏电保护系统总体设计与实现

孙玉坤,朱志莹,黄振跃,唐平

《中国工程科学》 2012年 第14卷 第7期   页码 93-97

摘要： 该系统在总开关处采用附加直流源检测原理检测是否发生漏电，在分支开关处使用零序功率方向检测原理判断发生漏电故障线路，给出了保护系统的硬件框图和软件流程图，并且采用速度更快的RS—485总线及光纤传输技术

关键词： 漏电保护     选择性     dsPIC30F4012     PIC16F877A     RS—485总线     光纤通信    

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Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

《医学前沿（英文）》 2007年 第1卷 第3期   页码 320-326 doi: 10.1007/s11684-007-0062-y

摘要： The aim of this study was to explore the association of the genetic polymorphism of and with the susceptibility to chronic benzene poisoning (CBP). A case-control study of 268 patients with CBP and 268 healthy workers matched by age and sex, all of whom were occupationally exposed to benzene, was conducted. The single nucleotide polymorphisms (SNPs, rs2854451, rs3738047, rs2234922 and rs1051741) of gene and the SNP (rs751141) of gene were tested by the TaqMan PCR method. In the subjects carrying the genotype of rs3738047 GG, the risk of CBP was decreased in the individuals simultaneously carrying rs2234922 G ( = 0.02). Alternatively, in the subjects carrying the genotype of rs2234922 AA, the risk of CBP was increased in the individuals simultaneously carrying the allele of rs751141A ( = 0.03). It was also found that there were potential interactions between alcohol consumption and the polymorphism of rs1051741 ( = 5.28, = 0.02) or rs2234922 (= 6.71, = 0.01). Compared to individuals with rs1051741 CC or rs2234922 AA genotype in the drinkers, the risk of CBP in those carrying genotypes of rs1051741 CT+TT or rs2234922 AG+GG was decreased, respectively ( = 0.04, 〈0.01). Haplotype analysis of polymorphisms in showed that the risk of CBP was increased in the subjects with haplotype 2 (rs2854451-A, rs3738047-G, rs2234922-A, rs1051741-C) or haplotype 4 (rs2854451-G, rs3738047-A, rs2234922-G, rs1051741-T), but decreased in those with haplotype 6 (rs2854451-G, rs3738047-G, rs2234922-G, rs1051741-T) or haplotype 10 (rs2854451-A, rs3738047-A, rs2234922-G, rs1051741-T), respectively. Logistic regression analysis revealed that smoking might play a role in modifying the risk of CBP (OR = 0.313, 95% CI: 0.123 0.794, = 0.015). The genetic polymorphism in may be associated with the risk of CBP in the Chinese occupational population and further research is needed for the association between the genetic polymorphism in and the susceptibility to CBP.

关键词： case-control     rs2854451     regression analysis     haplotype     further research    

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一款基于改进的步进式译码算法实现的流水线架构RS码译码器 Article

Xing-ru PENG,Wei ZHANG,Yan-yan LIU

《信息与电子工程前沿（英文）》 2016年 第17卷 第9期   页码 954-961 doi: 10.1631/FITEE.1500303

摘要： 概要：基于改进的步进式译码算法，我们为超宽带系统设计了一款流水线架构的Reed-Solomon（RS）码译码器。为了减小复杂度，改进的步进式译码算法将传统步进式译码算法中冗余的两部分进行了结合。因此，对于RS（23,17）码，我们所设计的译码器面积比ME（modified Euclidean）架构和pDCME（pipelined degree-computationless modified

关键词： Reed-Solomon码；步进式译码算法；超宽带；流水线架构    

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标题 作者 时间 类型 操作

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk

null

期刊论文

Genetic variation of carotenoids in Chinese bread wheat cultivars and the effect of the 1BL.1RS translocation

Wenshuang LI,Shengnan ZHAI,Hui JIN,Weie WEN,Jindong LIU,Xianchun XIA,Zhonghu HE

期刊论文

矿井低压电网选择性漏电保护系统总体设计与实现

孙玉坤,朱志莹,黄振跃,唐平

期刊论文

Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

期刊论文

一款基于改进的步进式译码算法实现的流水线架构RS码译码器

Xing-ru PENG,Wei ZHANG,Yan-yan LIU

期刊论文