Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 3

会议视频 1

年份

2022 2

2009 1

2008 1

关键词

男性不育症 1

精子参数 1

自然妊娠率 1

药物 1

营养健康 1

补充剂 1

展开︾

检索范围：

排序：展示方式：

optimization for enhanced hyaluronic acid production by batch culture of Sreptococcus zooepidemicus via the supplement

Long LIU, Haiquan YANG, Guocheng DU, Miao WANG, Jian CHEN,

《化学科学与工程前沿（英文）》 2009年第3卷第4期页码 351-356 doi: 10.1007/s11705-009-0248-8

摘要： This work is aimed to achieve the optimal hyaluronic acid (HA) production by batch culture of via the supplement of nucleotide bases using response surface methodology (RSM). First, the influence of nucleotide bases (adenine, guanine, cytosine, thymine, and uracil) on microbial HA production was investigated using fractional factorial design (FFD). By a 2 FFD, uracil was found to be the most significant factor for cell growth and HA production, while the other nucleotide bases were shown to have no significant effects on cell growth and HA production. Also, the impact of uracil on cell growth and HA production was further investigated by RSM, where two variables were considered: uracil concentration and supplement time. The optimal uracil concentration and supplement time were found to be 0.051g/L and 7h, respectively, and the predicted maximal HA production reached 6.42g/L. The maximal HA production increased from 5.0g/L of the control without uracil supplement to 6.31g/L at the optimal conditions in validation experiments.

关键词： control microbial HA thymine influence culture

HTML PDF 收藏

Changes of ecological conditions induced by rock tunneling in Laoshan Mountain area

LI Xiaozhao, ZHAO Xiaobao, WANG Zhongsheng

《结构与土木工程前沿（英文）》 2008年第2卷第4期页码 366-370 doi: 10.1007/s11709-008-0056-0

摘要： Through field investigation, this paper examined the changes of ecological conditions induced by tunnel construction in Laoshan Mountain area, Nanjing, Jiangsu Province, P. R. China. The effects of habitat fragmentation and edge effect are examined and discussed. It is found that the environmental factors and vegetation situation have been influenced by the tunneling activity, and the disturbed area is approaching the sampling patch centre. The changed ecological conditions are beneficial for the settlement and growth of some herb and shrub species, and are unfavorable for the existence and growth of saplings, especially for the predominant species (e.g., robur) in this area. If the time of habitat fragmentation is long enough and there is no supplement from external areas, some vegetation species in the engineering influencing area will deteriorate, or even diminish in the future. The results can be used as a reference for the long-term ecological study in this area.

关键词： supplement fragmentation reference tunneling activity vegetation situation

HTML PDF 收藏

一项关于药物和补充剂对改善男性不育症患者的自然妊娠和精液参数影响的系统综述和网状荟萃分析 Article

李建, 吴奇, Ernest Hung Yu Ng, Ben Willem J. Mol, 吴效科, Chi Chiu Wang

《工程（英文）》 2022年第16卷第9期页码 198-209 doi: 10.1016/j.eng.2021.07.009

摘要：

本研究采用网状荟萃分析对药物和补充剂治疗特发性男性不育症的疗效进行比较，以获得最佳治疗方法。对Medline、EMBASE、OVID和CNKI等数据库中发表于1990年1月至2021年6月的文献进行检索，检索关键词包括“男性不育”“药物疗法”“补充/营养疗法”及其相关术语等。将研究药物[主要包括促卵泡激素（FSH）、雄激素、克罗米芬/他莫昔芬（SERM）]或补充剂[主要是锌、硒、维生素C/E、卡尼丁、辅酶Q₁₀（CoQ₁₀）或联合治疗]治疗特发性不育男性的随机对照试验（RCT）纳入meta分析。按PRISMA声明中的报告规范提取数据，并使用偏倚风险工具和适用于网状meta分析的GRADE系统评估证据质量。研究的主要结局是活产率和自然妊娠率（SPR），次要结局是精子参数（包括精子浓度、前向运动百分比和形态）和不良反应。65项RCT被纳入分析，共包括7541名精子参数异常但激素水平正常的育龄男性。36项研究报道SPR，但仅三项研究报道活产率。纳入研究的质量评价为中、高级。与安慰剂或未治疗相比，卡尼汀联合维生素治疗显著增加SPR（RR = 3.7, 95% CI为1.6 ~ 8.5），脂肪酸补充剂显著增加精子浓度（MD = 12.5 × 10⁶ mL^–1, 95% CI为3.1 × 10⁶ ~ 22.0 × 10⁶）。SERM联合辅酶Q₁₀显著提升前向活力精子（MD = 11.0%, 95% CI为0.1% ~ 21.9%）和正常形态精子（MD = 11.0%, 95% CI为4.6% ~ 17.4%）。对改善SPR和精子浓度的最佳治疗方案分别是卡尼汀联合维生素和脂肪酸补充剂，即便排除具有高偏倚风险的研究，结果仍保持一致。对于少弱精子症男性，与安慰剂或未治疗相比，FSH（RR = 4.9, 95% CI为1.1 ~ 21.3）显著增加SPR，而SERM联合激肽酶可显著增加精子浓度（MD = 16.5 × 10⁶ mL^–1, 95% CI为1.6 × 10⁶ ~ 31.4 × 10⁶)，SERM联合辅酶Q₁₀则显著改善前向活力精子（MD = 11.3%, 95% CI为7.3% ~ 15.4%）和正常形态精子（MD = 11.2%, 95% CI为 5.4% ~ 16.9%）。在不良反应方面，脂肪酸补充剂和己酮可可碱分别与口臭或味觉差（RR = 8.1, 95% CI为1.0 ~ 63.5）和呕吐（RR = 8.0, 95% CI为1.0 ~ 63.0）相关。综上所述，对于改善不育男性配偶活产率的最佳治疗方案仍然不清楚。对于所有不孕夫妇和男性少弱精症不孕夫妇，卡尼汀联合维生素和FSH方案在成功实现自然妊娠方面分别优于其他方案。其他治疗方法对妊娠结局的疗效仍需要进一步验证。