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期刊论文 1

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2008 1

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Current techniques for assessing developmental neurotoxicity of pesticides

GAO Yu, TIAN Ying, SHEN Xiaoming

《医学前沿（英文）》 2008年 第2卷 第4期   页码 337-343 doi: 10.1007/s11684-008-0064-4

摘要： Organophosphates (OPs) and Pyrethroids (PRY) have been widely used in agriculture and in the home as broad spectrum insecticides, but may produce considerable risk to human health, especially to children. Children are more susceptible to environmental exposure, and concern about the neurotoxic effects of pesticide exposure on children is increasing. There is a need for better understanding of the potential developmental neurotoxicity of pesticides. Techniques for assessing developmental neurotoxicity of pesticides will continue to be developed, rendering a need for flexibility of testing paradigms. Current techniques used in evaluating the developmental neurotoxicity of OPs and PRY are presented in this review. These include: (1) techniques (PC12 cells, C6 cells and other cell models); (2) Non-mammalian models (sea urchins, zebrafish and other non-mammalian models); and (3) mammalian models (morphological techniques, neurobehavioral assessments and biomarkers).

关键词： paradigms     Pyrethroids     non-mammalian     susceptible     morphological    

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Current techniques for assessing developmental neurotoxicity of pesticides

GAO Yu, TIAN Ying, SHEN Xiaoming

期刊论文