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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

《医学前沿（英文）》 2023年 第17卷 第2期   页码 240-262 doi: 10.1007/s11684-022-0936-z

摘要： Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

关键词： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Modified Bishop method for stability analysis of weakly sloped subgrade under centrifuge model test

《结构与土木工程前沿（英文）》 2021年 第15卷 第3期   页码 727-741 doi: 10.1007/s11709-021-0730-z

摘要： The sliding forms of weak sloped and horizontal subgrades during the sliding process differ. In addition, the sliding form of weakly sloped subgrades exhibits considerable slippage and asymmetry. The accuracy of traditional slice methods for computing the stability safety factor of weakly sloped subgrades is insufficient for a subgrade design. In this study, a novel modified Bishop method was developed to improve the accuracy of the stability safety factor for different inclination angles. The instability mechanism of the weakly sloped subgrade was considered in the proposed method using the “influential force” and “additional force” concepts. The “additional force” reflected the weight effect of the embankment fill, whereas the “influential force” reflected the effect of the potential energy difference. Numerical simulations and experimental tests were conducted to evaluate the advantages of the proposed modified Bishop method. Compared with the traditional slice method, the error between the proposed method and the exact value is less than 32.3% in calculating the safety factor.

关键词： weakly sloped subgrade     stability analysis     additional force     influential force     modified Bishop method    

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CLIMATE-CHANGE-INDUCED TEMPORAL VARIATION IN PRECIPITATION INCREASES NITROGEN LOSSES FROM INTENSIVE CROPPINGSYSTEMS: ANALYSIS WITH A TOY MODEL

《农业科学与工程前沿（英文）》 2022年 第9卷 第3期   页码 457-464 doi: 10.15302/J-FASE-2022452

摘要：

● A simple model was used to evaluate how increasing temporal variability in precipitation influences crop yields and nitrogen losses.

关键词： crop yield     fertilizer timing     nitrogen loss     precipitation variability     toy model    

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Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns and gravel lenses

Hiruy ABDU, David A. ROBINSON, Janis BOETTINGER, Scott B. JONES

《农业科学与工程前沿（英文）》 2017年 第4卷 第2期   页码 135-145 doi: 10.15302/J-FASE-2017143

摘要： Knowledge of the spatial distribution of soil textural properties is important for determining soil moisture storage and soil hydraulic transport properties. Capturing field heterogeneity without exhaustive sampling and costly sample analysis is difficult. Our objective was to employ electromagnetic induction (EMI) mapping in low apparent electrical conductivity (EC ) soils at varying soil water contents to capture time invariant properties such as soil texture. Georeferenced EC measurements were taken using a ground conductivity meter on six different days where volumetric water content ( ) varied from 0.11 to 0.23. The 50 m × 50 m field included a subsurface gravelly patch in an otherwise homogeneous silt-loam alluvial soil. Ordinary block kriging predicted EC at unsampled areas to produce 1-m resolution maps. Temporal stability analysis was used to divide the field into three distinct EC regions. Subsequent ground-truthing confirmed the lowest conductivity region correlated with coarse textured soil parent materials associated with a former high-energy alluvial depositional area. Combining maps using temporal stability analysis gives the clearest image of the textural difference. These maps could be informative for modeling, experimental design, sensor placement and targeted zone management strategies in soil science, ecology, hydrology, and agricultural applications.

关键词： soil electrical conductivity     soil texture mapping     temporal stability analysis    

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Spatio-temporal variations of water quality in Yuqiao Reservoir Basin, North China

Yuan XU,Ruqin XIE,Yuqiu WANG,Jian SHA

《环境科学与工程前沿（英文）》 2015年 第9卷 第4期   页码 649-664 doi: 10.1007/s11783-014-0702-9

摘要： Fuzzy comprehensive assessment and multivariate statistical techniques including cluster analysis, discriminant analysis, principal component analysis, and factor analysis were applied to analyze the water quality status of Yuqiao Reservoir Basin, North China, for assessing its spatio-temporal variations and identifying potential pollution sources. In this paper, we considered data for 14 water quality parameters collected during 1990–2004 at 7 water quality monitoring sites. The results of fuzzy comprehensive assessment revealed that water quality in Yuqiao Reservoir Basin showed a downtrend from 1990 to 2001 with fluctuation, and a slowly upward trend after 2001. The major water quality belonged to Class III and IV. Besides, hierarchical cluster analysis divided 7 monitoring sites into two groups (Group A and B), and 12 months into three periods (low-flow (LF), normal-flow (NF), and high-flow (HF) period). Temp, pH, SS, T-har, DO, NO -N and TP were identified as significant variables affecting spatial variations, and Temp, pH and NO -N were identified as significant variables affecting temporal variations by discriminant analysis. Factor analysis identified four latent pollution sources for water quality variations: nutrient pollution, organic pollution, inorganic pollution, and natural pollution. Moreover, for Group A regions, pollution inputs mainly came from domestic wastewater and industrial sewage. For Group B regions, it is more likely that water pollution resulted from the combined effects of domestic wastewater, hospital wastewater, agriculture runoff, and fishpond discharge, as well as the incoming water from upstream.

关键词： Fuzzy comprehensive assessment     multivariate statistical analysis     water quality    

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Allocation of grassland, livestock and arable based on the spatial and temporal analysis for food demand

Huilong LIN, Ruichao LI, Yifan LIU, Jingrong ZHANG, Jizhou REN

《农业科学与工程前沿（英文）》 2017年 第4卷 第1期   页码 69-80 doi: 10.15302/J-FASE-2017140

摘要： To explore the distribution of food demand and the projected trend in future food demand in China, this paper analyzed the change in current (1998–2012) per-capita demand for grain, grain-consuming and herbivorous livestock products, and predicted the food demand in 2020. The results indicated that in 1998–2012, the national per-capita consumption of grain ration declined by about 36.66%, and the per-capita consumption of grain-consu-ming and herbivorous livestock products increased by about 48% and 34.09%, respectively. The grain-consu-ming livestock products have become the primary source of both calories and protein for consumers. The proportion of herbivorous livestock products in consumer diets has increased steadily and there has been huge potential in substituting beef and mutton for pork in this dynamic market. The demand for food in different provinces of China is highly variable, which is important for planning grassland agriculture development and ensuring food safety. The demand for grain, and grain-consuming and herbivorous livestock products will increase by about 3.3%, 20% and 14% respectively by 2020. Based on the food demand and trend in the development of grassland agriculture, the 31 provinces in China are divided into three priority groups for grassland agriculture development.

关键词： arable land equivalent unit (ALEU)     food equivalent unit (FEU)     food security     grassland agriculture     time trend prediction    

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Three-dimensional stability analysis of the dam foundation at Baise

XU Qianjun, LI Xu, CHEN Zuyu

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 217-221 doi: 10.1007/s11709-007-0026-y

摘要： It is usually difficult to determine the actual safety factors of rock masses in an ordinary two-dimensional stability analysis if the safety factors of the different cross sections in the rock mass vary significantly. In addition to the actual slope, arch dam abutment, and the actual foundation of a high building, another example is that the different cross sections of the foundation in the monolith of a gravity dam vary significantly, just like the condition at the overflow dam in the Baise project. A three-dimensional stability analysis method based on the upper-bound theorem was employed to solve this problem. The parameters used in the analysis were obtained from geomechanics tests, as well as continuity simulations of the randomly distributed joints. Two failure patterns against sliding are analyzed. One pattern is the foundation slide along deep-seated planes which were determined by calculations. The other pattern is the foundation slide along the planes across the bottom of the high steps in the foundation pit. The results indicate that a special overflow dam monolith can be considered to be safe in case of considering the three dimensional effect. However, a key wall with a depth of 5m must be constructed at the upper side of this monolith in order to ensure the safety of the foundation.

关键词： ordinary two-dimensional     randomly     monolith     three-dimensional stability     different    

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Design and stability analysis of continuous skew tied-arch bridge over Bin Jiang River

YU Jiancheng, TONG Hao, HUANG Wei

《结构与土木工程前沿（英文）》 2008年 第2卷 第1期   页码 37-42 doi: 10.1007/s11709-008-0004-z

摘要： A tied arch bridge without wind bracing was built over the Bin Jiang River, with oblique angle of 20°. Its main design details are described and mechanical performances are analyzed. The stability analytical types are also introduced and the first elastic stability theory is used. A space finite element model has been built to analyze the stability performances in both construction and operation stages for single span or continuous, orthogonal or oblique bridge. The influence of stiffness of the end crossbeam is also analyzed. The result shows that out-plane buckling occur for a rigid tie and similar no matter whether it is single span or continuous and orthogonal or oblique. When there are more and stronger inner crossbeams, the influence of the end crossbeams on arch stability becomes unremarkable.

关键词： out-plane buckling     unremarkable     crossbeam     stability analytical     orthogonal    

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Industrial eco-efficiency and its spatial-temporal differentiation in China

Wei YANG, Fengjun JIN, Chengjin WANG, Chen LV

《环境科学与工程前沿（英文）》 2012年 第6卷 第4期   页码 559-568 doi: 10.1007/s11783-012-0400-4

摘要： The aim of this paper is to study the spatial-temporal differentiation of industrial eco-efficiency in China. Using methods based on the data envelopment analysis (DEA) model and exploratory spatial data analysis (ESDA) and data from 1985, 1995, 2005, and 2008 of 30 provinces in China, the spatial-temporal pattern changes in industrial eco-efficiency are discussed. The results show that: first, the patterns of industrial eco-efficiency are dominated by clustering of relatively low efficiency provinces; second, spatial relationships between the industrial eco-efficiencies of different provinces changed slightly throughout the period and the provinces persistently exhibit spatial concentration of relatively low industrial eco-efficiency; finally, there is an obvious trend in the polarization of industrial eco-efficiency, i.e., the higher level spatial units are concentrated in eastern China, and the lower level spatial units are mainly in western and central China.

关键词： industrial eco-efficiency     data envelopment analysis (DEA) model     exploratory spatial data analysis (ESDA)    

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Stability analysis of layered slopes in unsaturated soils

Guangyu DAI; Fei ZHANG; Yuke WANG

《结构与土木工程前沿（英文）》 2022年 第16卷 第3期   页码 378-387 doi: 10.1007/s11709-022-0808-2

摘要： This study presents stability analyses of layered soil slopes in unsaturated conditions and uses a limit equilibrium method to determine the factor of safety involving suction stress of unsaturated soil. One-dimensional steady infiltration and evaporation conditions are considered in the stability analyses. An example of a two-layered slope in clay and silt is selected to verify the used method by comparing with the results of other methods. Parametric analyses are conducted to explore the influences of the matric suction on the stability of layered soil slopes. The obtained results show that larger suction stress provided in unsaturated clay dominates the stability of the layered slopes. Therefore, the location and thickness of the clay layer have significant influences on slope stability. As the water level decreases, the factor of safety reduces and then increases gradually in most cases. Infiltration/evaporation can obviously affect the stability of unsaturated layered slopes, but their influences depend on the soil property and thickness of the lower soil layer.

关键词： slope stability     suction stress     unsaturated soil     layered slope     limit equilibrium    

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Nonlinear analysis of pre-tensioned glass wall facade by stability function with initial imperfection

Siu-Lai CHAN, Yaopeng LIU, Andy LEE,

《结构与土木工程前沿（英文）》 2010年 第4卷 第3期   页码 376-382 doi: 10.1007/s11709-010-0086-2

摘要： Pre-tensioned high strength trusses using alloy steel bar are widely used as glass wall supporting systems because of the high degree of transparency. The breakage of glass panes in this type of system occurs occasionally, likely to be due to error in design and analysis in addition to other factors like glass impurity and stress concentration around opening in a spider system. Most design does not consider the flexibility of supports from finite stiffness of supporting steel or reinforced concrete beams. The resistance of lateral wind pressure of the system makes use of high tension force coupled with the large deflection effect, both of which are affected by many parameters not generally considered in conventional structures. In the design, one must therefore give a careful consideration on various effects, such as support settlement due to live loads and material creep, temperature change, pre-tension force, and wind pressure. It is not uncommon to see many similar glass wall systems fail in the wind load test chambers under a design wind speed. This paper presents a rigorous analysis and design of this type of structural systems used in a project in Hong Kong, China. The stability function with initial curvature is used in place of the cubic function, which is only accurate for linear analysis. The considerations and analysis techniques are believed to be of value to engineers involved in the design of the structural systems behaving nonlinearly.

关键词： tension system     glass wall     nonlinear analysis     pre-tensioning     second-order analysis    

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Assessment of temporal and spatial variations in water quality using multivariate statistical methods

Xue LI,Pengjing LI,Dong WANG,Yuqiu WANG

《环境科学与工程前沿（英文）》 2014年 第8卷 第6期   页码 895-904 doi: 10.1007/s11783-014-0736-z

摘要： This study evaluated the temporal and spatial variations of water quality data sets for the Xin'anjiang River through the use of multivariate statistical techniques, including cluster analysis (CA), discriminant analysis (DA), correlation analysis, and principal component analysis (PCA). The water samples, measured by ten parameters, were collected every month for three years (2008–2010) from eight sampling stations located along the river. The hierarchical CA classified the 12 months into three periods (First, Second and Third Period) and the eight sampling sites into three groups (Groups 1, 2 and 3) based on seasonal differences and various pollution levels caused by physicochemical properties and anthropogenic activities. DA identified three significant parameters (temperature, pH and ) to distinguish temporal groups with close to 76% correct assignment. The DA also discovered five parameters (temperature, electricity conductivity, total nitrogen, chemical oxygen demand and total phosphorus) for spatial variation analysis, with 80.56% correct assignment. The non–parametric correlation coefficient (Spearman R) explained the relationship between the water quality parameters and the basin characteristics, and the GIS made the results visual and direct. The PCA identified four PCs for Groups 1 and 2, and three PCs for Group 3. These PCs captured 68.94%, 67.48% and 70.35% of the total variance of Groups 1, 2 and 3, respectively. Although natural pollution affects the Xin'anjiang River, the main sources of pollution included agricultural activities, industrial waste, and domestic wastewater.

关键词： Xin'anjiang River     multivariable statistical analysis     temporal variation     spatial variation     water quality    

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Slope stability analysis based on big data and convolutional neural network

Yangpan FU; Mansheng LIN; You ZHANG; Gongfa CHEN; Yongjian LIU

《结构与土木工程前沿（英文）》 2022年 第16卷 第7期   页码 882-895 doi: 10.1007/s11709-022-0859-4

摘要： The Limit Equilibrium Method (LEM) is commonly used in traditional slope stability analyses, but it is time-consuming and complicated. Due to its complexity and nonlinearity involved in the evaluation process, it cannot provide a quick stability estimation when facing a large number of slopes. In this case, the convolutional neural network (CNN) provides a better alternative. A CNN model can process data quickly and complete a large amount of data analysis in a specific situation, while it needs a large number of training samples. It is difficult to get enough slope data samples in practical engineering. This study proposes a slope database generation method based on the LEM. Samples were amplified from 40 typical slopes, and a sample database consisting of 20000 slope samples was established. The sample database for slopes covered a wide range of slope geometries and soil layers’ physical and mechanical properties. The CNN trained with this sample database was then applied to the stability prediction of 15 real slopes to test the accuracy of the CNN model. The results show that the slope stability prediction method based on the CNN does not need complex calculation but only needs to provide the slope coordinate information and physical and mechanical parameters of the soil layers, and it can quickly obtain the safety factor and stability state of the slopes. Moreover, the prediction accuracy of the CNN trained by the sample database for slope stability analysis reaches more than 99%, and the comparisons with the BP neural network show that the CNN has significant superiority in slope stability evaluation. Therefore, the CNN can predict the safety factor of real slopes. In particular, the combination of typical actual slopes and generated slope data provides enough training and testing samples for the CNN, which improves the prediction speed and practicability of the CNN-based evaluation method in engineering practice.

关键词： slope stability     limit equilibrium method     convolutional neural network     database for slopes     big data    

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Surficial stability analysis of soil slope under seepage based on a novel failure mode

《结构与土木工程前沿（英文）》 2021年 第15卷 第3期   页码 712-726 doi: 10.1007/s11709-021-0729-5

摘要： Normally, the edge effects of surficial landslides are not considered in the infinite slope method for surficial stability analysis of soil slopes. In this study, the limit stress state and discrimination equation of an infinite slope under saturated seepage flow were analyzed based on the Mohr-Coulomb strength criterion. Therefore, a novel failure mode involving three sliding zones (upper tension zone, middle shear sliding zone, and lower compression zone) was proposed. Accordingly, based on the limit equilibrium analysis, a semi-analytical framework considering the edge effect for the surficial stability of a soil slope under downslope seepage was established. Subsequently, the new failure mode was verified via a numerical finite element analysis based on the reduced strength theory with ABAQUS and some simplified methods using SLIDE software. The results obtained by the new failure mode agree well with those obtained by the numerical analysis and traditional simplified methods, and can be efficiently used to assess the surficial stability of soil slopes under rainwater seepage. Finally, an evaluation of the infinite slope method was performed using the semi-analytical method proposed in this study. The results show that the infinite slope tends to be conservative because the edge effect is neglected, particularly when the ratio of surficial slope length to depth is relatively small.

关键词： soil slope     seepage     surficial failure mode     stress state     edge effects    

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On the seismic stability analysis of reinforced rock slope and optimization of prestressed cables

Wenbo ZHENG, Xiaoying ZHUANG, Yongchang CAI

《结构与土木工程前沿（英文）》 2012年 第6卷 第2期   页码 132-146 doi: 10.1007/s11709-012-0152-z

摘要： The evaluation of the seismic stability of high rock slopes is of vital importance to ensure the safe operation of the hydropower stations. In this paper, an equivalent pseudo-static force analysis based on the finite element method is developed to evaluate the seismic stability of reinforced rock slopes where the prestressed cables are modeled by the bar elements applied with nodal forces and bounded only at the anchored parts. The method is applied to analyze a high rock slope in south-west China and the optimization of cables. The stabilization effects of prestressed cables on the seismic stability of the slope are studied, the simulations of the concrete heading are discussed and the potential failure modes of the shear concrete plug are compared. Based on this, the optimization of cables is studied including the anchor spacing and inclined angles.

关键词： high rock slope     reinforced system     optimization     prestressed cable     seismicity    

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标题 作者 时间 类型 操作

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

期刊论文

Modified Bishop method for stability analysis of weakly sloped subgrade under centrifuge model test

期刊论文

CLIMATE-CHANGE-INDUCED TEMPORAL VARIATION IN PRECIPITATION INCREASES NITROGEN LOSSES FROM INTENSIVE CROPPINGSYSTEMS: ANALYSIS WITH A TOY MODEL

期刊论文

Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns and gravel lenses

Hiruy ABDU, David A. ROBINSON, Janis BOETTINGER, Scott B. JONES

期刊论文

Spatio-temporal variations of water quality in Yuqiao Reservoir Basin, North China

Yuan XU,Ruqin XIE,Yuqiu WANG,Jian SHA

期刊论文

Allocation of grassland, livestock and arable based on the spatial and temporal analysis for food demand

Huilong LIN, Ruichao LI, Yifan LIU, Jingrong ZHANG, Jizhou REN

期刊论文

Three-dimensional stability analysis of the dam foundation at Baise

XU Qianjun, LI Xu, CHEN Zuyu

期刊论文

Design and stability analysis of continuous skew tied-arch bridge over Bin Jiang River

YU Jiancheng, TONG Hao, HUANG Wei

期刊论文

Industrial eco-efficiency and its spatial-temporal differentiation in China

Wei YANG, Fengjun JIN, Chengjin WANG, Chen LV

期刊论文

Stability analysis of layered slopes in unsaturated soils

Guangyu DAI; Fei ZHANG; Yuke WANG

期刊论文

Nonlinear analysis of pre-tensioned glass wall facade by stability function with initial imperfection

Siu-Lai CHAN, Yaopeng LIU, Andy LEE,

期刊论文

Assessment of temporal and spatial variations in water quality using multivariate statistical methods

Xue LI,Pengjing LI,Dong WANG,Yuqiu WANG

期刊论文

Slope stability analysis based on big data and convolutional neural network

Yangpan FU; Mansheng LIN; You ZHANG; Gongfa CHEN; Yongjian LIU

期刊论文

Surficial stability analysis of soil slope under seepage based on a novel failure mode

期刊论文

On the seismic stability analysis of reinforced rock slope and optimization of prestressed cables

Wenbo ZHENG, Xiaoying ZHUANG, Yongchang CAI

期刊论文