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Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

《机械工程前沿（英文）》 2011年 第6卷 第4期   页码 409-418 doi: 10.1007/s11465-011-0245-8

摘要：

The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order shear deformation theory (TSDT) is studied. The beam is made of laminated composite, and located on a Pasternak viscoelastic foundation. By using the principle of total minimum potential energy, the governing partial differential equations of motion are obtained. The solution is directed to compute the deflection and bending moment distribution along the length of the beam. Also, the effects of two types of composite materials, stiffness and shear layer viscosity coefficients of foundation, velocity and frequency of the moving load over the beam response are studied. In order to demonstrate the accuracy of the present method, the results TSDT are compared with the previously obtained results based on first-order shear deformation theory, with which good agreements are observed.

关键词： timoshenko composite beam     pasternak viscoelastic foundation     third-order shear deformation theory (TSDT)     harmonic moving load    

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Numerical simulation of three-dimensional turbulent flow in multistage axial compressor blade row

JIANG Jian, LIU Bo, WANG Yangang, NAN Xiangyi

《能源前沿（英文）》 2008年 第2卷 第3期   页码 320-325 doi: 10.1007/s11708-008-0041-2

摘要： Numerical simulation of three-dimensional turbulent flow in a multistage axial compressor blade row is conducted. A high resolution, third-order ENN scheme is adopted to catch the shockwave and simulate the turbulent flow correctly,

关键词： simulation     compressor     multistage     third-order     three-dimensional turbulent    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 383-388 doi: 10.1007/s11684-016-0488-1

摘要：

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.

关键词： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

《医学前沿（英文）》 2022年 第16卷 第5期   页码 701-713 doi: 10.1007/s11684-022-0951-0

摘要： A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), such as osimertinib, which have shown remarkable success in the treatment of advanced NSCLC with EGFR activating mutations, in order to achieve maximal response duration or treatment remission. Apoptosis is a major type of programmed cell death tightly associated with cancer development and treatment. Evasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquired resistance in cancer therapy. It has been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIs, particularly osimertinib, to exert their therapeutic efficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquired resistance. Hence, restoration of cell sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs.

关键词： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

《医学前沿（英文）》 2022年 第16卷 第1期   页码 93-101 doi: 10.1007/s11684-021-0914-x

摘要： Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via vaccination is essential to combat the current pandemic of coronavirus disease 2019 (COVID-19). It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time, which calls for an additional vaccination regime, as known as booster immunization, to restore immunity among previously vaccinated populations. Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccine (Vero cell), on 136 participants aged between 18 to 63 years. Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28. While systemic reactogenicity was either absent or mild, SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks, surpassing the peak antibody titers elicited by the initial two-dose immunization regime. Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination. Furthermore, in an exploratory study, a newly developed recombinant protein vaccine, NVSI-06-08 (CHO Cells), was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals. Together, these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity, providing support for further trials of booster vaccination in larger populations.

关键词： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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High-order phase-field model with the local and second-order max-entropy approximants

Fatemeh AMIRI

《结构与土木工程前沿（英文）》 2019年 第13卷 第2期   页码 406-416 doi: 10.1007/s11709-018-0475-5

摘要： We approximate the fracture surface energy functional based on phase-field method with smooth local maximum entropy (LME) and second-order maximum entropy (SME) approximants. The higher-order continuity of the meshfree methods such as LME and SME approximants allows to directly solve the fourth-order phase-field equations without splitting the fourth-order differential equation into two second-order differential equations. We will first show that the crack surface functional can be captured more accurately in the fourth-order model with smooth approximants such as LME, SME and B-spline. Furthermore, smaller length scale parameter is needed for the fourth-order model to approximate the energy functional. We also study SME approximants and drive the formulations. The proposed meshfree fourth-order phase-field formulation show more stable results for SME compared to LME meshfree methods.

关键词： second-order maximum entropy     local maximum entropy     second- and fourth-order phase-field models     B-spline    

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An assemble-to-order production planning with the integration of order scheduling and mixed-model sequencing

Baoxi WANG, Zailin GUAN, Yarong CHEN, Xinyu SHAO, Ming JIN, Chaoyong ZHANG

《机械工程前沿（英文）》 2013年 第8卷 第2期   页码 137-145 doi: 10.1007/s11465-013-0251-0

摘要：

For assemble-to-order enterprises, both order scheduling and mixed-model sequencing need to be taken into consideration in the formulation of order-oriented assembly plan. First, determining production priority for the received orders, and then conducting assembly sequence to the mixed-model products in each order. Order scheduling is aimed to ensure order delivery with the optimization goal of minimal total overdue time, while product sequencing is aimed to minimize the makespan so as to meet the requirement on completion time of the order. In the end, the paper establishes a mixed integer programming model based on an industrial case, and makes programming calculation with Xpress-MP to accomplish an order-oriented assembly plan conforming to actual production.

关键词： mixed-model assembly line     assemble-to-order     order scheduling     sequencing    

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Split-order consolidation optimization for online supermarkets: Process analysis and optimization models

《工程管理前沿（英文）》   页码 499-516 doi: 10.1007/s42524-022-0221-5

摘要： The large-scale online supermarket is a newly emerging online retailing mode which brings great convenience to people. Online supermarkets are characterized by having large amounts of daily orders with potentially multiple items, diverse delivery times, and a high order-split rate. Multiple shipments for one order caused by order splitting result in high cost and disturbance and a large number of discarded consumable packages at online retailers and customers, causing severe damage to the environment. Accordingly, research on split-order consolidation fulfilment is critical for the advancement of the practice and theory in the context of highly complex online retailing. This paper first analyzes the characteristics and the challenges associated with the split-order consolidation problem that online supermarket is confronting and summarizes the new operational process of split-order consolidation fulfilment. Then, a time–space network optimization model is built, and its corresponding solution algorithm is presented to solve the questions of where and when to consolidate the split orders. Finally, the computation results of the numerical experiments are provided to verify the effectiveness of the algorithm, and a sensitivity analysis of the relevant parameters is performed. This work highlights the effect of order consolidation processes and fulfilment methods on the order fulfilment decision-making for online supermarkets. The purpose of this article is to help pave the way for more effective online supermarket management and order implementation.

关键词： online supermarkets     split-order consolidation     time–space network     genetic algorithm    

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Comparison between linear and non-linear forms of pseudo-first-order and pseudo-second-order adsorption

Junxiong LIN , Lan WANG ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 320-324 doi: 10.1007/s11783-009-0030-7

摘要： The best-fit equations of linear and non-linear forms of the two widely used kinetic models, namely pseudo-first-order and pseudo-second-order equations, were compared in this study. The experimental kinetics of methylene blue adsorption on activated carbon was used for this research. Both the correlation coefficient () and the normalized standard deviation Δ(%) were employed as error analysis methods to determine the best-fitting equations. The results show that the non-linear forms of pseudo-first-order and pseudo-second-order models were more suitable than the linear forms for fitting the experimental data. The experimental kinetics may have been distorted by linearization of the linear kinetic equations, and thus, the non-linear forms of kinetic equations should be primarily used to obtain the adsorption parameters. In addition, the Δ(%) method for error analysis may be better to determine the best-fitting model in this case.

关键词： adsorption     pseudo-first order     pseudo-second order     kinetic model     linear method     non-linear method    

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Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

《结构与土木工程前沿（英文）》 2011年 第5卷 第3期   页码 315-322 doi: 10.1007/s11709-011-0117-7

摘要： Load and resistance factors are generally obtained using the first order reliability method (FORM) in which the design point should be determined and derivative-based iterations used. In this article, the third-moment reliability index, based on the three-parameter lognormal (3P-lognormal) distribution, is investigated. A simple method based on the third-moment method for estimating load and resistance factors is then proposed, and a simple formula for the target mean resistance is also presented to avoid iterative computations. Unlike the currently used method, the proposed method can be used to determine load and resistance factors, even when the probability density functions (PDFs) of the basic random variables are not available. Moreover, the proposed method does not require the iterative computation of derivatives or any design points. Thus, the method provides a more convenient and effective way to estimate load and resistance factors in practical engineering applications. Numerical examples are presented to demonstrate the advantages of the proposed third moment method for determining load and resistance factors.

关键词： load and resistance factors     third-moment method     three-parameter lognormal (3P-lognormal) distribution     target mean resistance     simple formula    

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Higher-order mode effects on the seismic performance of tall piers

Zhongguo GUAN, Jianzhong LI, Yan XU, Hao LU

《结构与土木工程前沿（英文）》 2011年 第5卷 第4期   页码 496-502 doi: 10.1007/s11709-011-0131-9

摘要： A comprehensive analysis was conducted to investigate the seismic performance of a typical tall bridge pier through incremental dynamical analysis (IDA). The effect of higher-order modes was studied specifically. The results showed that higher-order modes significantly contributed to the structural seismic response and should not be neglected. Including these modes resulted in an additional hinge midway up the pier. No plastic hinge would occur at this location for conventional bridge piers. Higher-order modes also led to an out-of-phase response between the hinge rotation at the pier bottom and the displacement at the top. This means that the displacement-based seismic design method cannot correctly predict the mechanical state of the critical hinge and therefore is not suitable for use in the seismic design of tall piers. Mistakenly using the displacement-based seismic design method for tall piers may result in a seriously unsafe condition.

关键词： tall bridges     higher-order mode effects     incremental dynamic analysis    

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第三届全球重大挑战峰会

Bartolomeo Maggie

《工程（英文）》 2017年 第3卷 第4期   页码 434-435 doi: 10.1016/J.ENG.2017.04.018

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Numerical simulation of sudden-expansion two-phase flows with two-scale second-order moment particle

ZENG Zhuoxiong, HAN Shoulei, ZHOU Lixing

《能源前沿（英文）》 2007年 第1卷 第2期   页码 202-206 doi: 10.1007/s11708-007-0026-6

摘要： A two-scale second-order moment particle turbulence model is developed, based on the concept of particle large-scale fluctuation due to turbulence and particle small-scale fluctuation due to collision. The model is employed to simulate gas-particle flows in a sudden-expansion chamber. Simulation results are compared with the experimental results and with those obtained by the single-scale second-order moment two-phase turbulence model. It is shown that the two-scale model is with higher calculating accuracy than the single-scale model.

关键词： gas-particle     single-scale second-order     large-scale fluctuation     second-order     sudden-expansion    

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Tacholess order-tracking approach for wind turbine gearbox fault detection

Yi WANG, Yong XIE, Guanghua XU, Sicong ZHANG, Chenggang HOU

《机械工程前沿（英文）》 2017年 第12卷 第3期   页码 427-439 doi: 10.1007/s11465-017-0452-z

摘要：

Monitoring of wind turbines under variable-speed operating conditions has become an important issue in recent years. The gearbox of a wind turbine is the most important transmission unit; it generally exhibits complex vibration signatures due to random variations in operating conditions. Spectral analysis is one of the main approaches in vibration signal processing. However, spectral analysis is based on a stationary assumption and thus inapplicable to the fault diagnosis of wind turbines under variable-speed operating conditions. This constraint limits the application of spectral analysis to wind turbine diagnosis in industrial applications. Although order-tracking methods have been proposed for wind turbine fault detection in recent years, current methods are only applicable to cases in which the instantaneous shaft phase is available. For wind turbines with limited structural spaces, collecting phase signals with tachometers or encoders is difficult. In this study, a tacholess order-tracking method for wind turbines is proposed to overcome the limitations of traditional techniques. The proposed method extracts the instantaneous phase from the vibration signal, resamples the signal at equiangular increments, and calculates the order spectrum for wind turbine fault identification. The effectiveness of the proposed method is experimentally validated with the vibration signals of wind turbines.

关键词： wind turbine     variable-speed operating conditions     Vold-Kalman filtering     tacholess order tracking    

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Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

《化学科学与工程前沿（英文）》 2021年 第15卷 第1期   页码 127-137 doi: 10.1007/s11705-020-1936-7

摘要： Effects of a benzotriazole (BTA)-based small molecule, BTA2, as the third component on the charge carrier generation and recombination behavior of poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl]] (PTB7):[6,6]-phenyl-C -butyric acid methyl ester (PC BM) organic solar cells (OSCs) were investigated by optical simulation of a transfer matrix model (TMM), photo-induced charge extraction by linearly increasing voltage (photo-CELIV) technique, atomic force microscope (AFM), and the Onsager–Braun model analysis. BTA2 is an A A D A A -type non-fullerene small molecule with thiazolidine-2,4-dione, BTA, and indacenodithiophene as the terminal acceptor (A ), bridge acceptor (A ), and central donor (D), respectively. The short-circuit current density of the OSCs with BTA2 can be enhanced significantly owing to a complementary absorption spectrum. The optical simulation of TMM shows that the ternary OSCs exhibit higher internal absorption than the traditional binary OSCs without BTA2, resulting in more photogenerated excitons in the ternary OSCs. The photo-CELIV investigation indicates that the ternary OSCs suffer higher charge trap-limited bimolecular recombination than the binary OSCs. AFM images show that BTA2 aggravates the phase separation between the donor and the acceptor, which is disadvantageous to charge carrier transport. The Onsager-Braun model analysis confirms that despite the charge collection efficiency of the ternary OSCs being lower than that of the binary OSCs, the optimized photon absorption and exciton generation processes of the ternary OSCs achieve an increase in photogenerated current and thus improve power conversion efficiency.

关键词： third component     organic solar cells     charge carrier generation     charge carrier recombination     bimolecular recombination    

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标题 作者 时间 类型 操作

Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

期刊论文

Numerical simulation of three-dimensional turbulent flow in multistage axial compressor blade row

JIANG Jian, LIU Bo, WANG Yangang, NAN Xiangyi

期刊论文

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

期刊论文

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

期刊论文

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

期刊论文

High-order phase-field model with the local and second-order max-entropy approximants

Fatemeh AMIRI

期刊论文

An assemble-to-order production planning with the integration of order scheduling and mixed-model sequencing

Baoxi WANG, Zailin GUAN, Yarong CHEN, Xinyu SHAO, Ming JIN, Chaoyong ZHANG

期刊论文

Split-order consolidation optimization for online supermarkets: Process analysis and optimization models

期刊论文

Comparison between linear and non-linear forms of pseudo-first-order and pseudo-second-order adsorption

Junxiong LIN , Lan WANG ,

期刊论文

Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

期刊论文

Higher-order mode effects on the seismic performance of tall piers

Zhongguo GUAN, Jianzhong LI, Yan XU, Hao LU

期刊论文

第三届全球重大挑战峰会

Bartolomeo Maggie

期刊论文

Numerical simulation of sudden-expansion two-phase flows with two-scale second-order moment particle

ZENG Zhuoxiong, HAN Shoulei, ZHOU Lixing

期刊论文

Tacholess order-tracking approach for wind turbine gearbox fault detection

Yi WANG, Yong XIE, Guanghua XU, Sicong ZHANG, Chenggang HOU

期刊论文

Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

期刊论文