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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

《医学前沿(英文)》 2023年 第17卷 第3期   页码 549-561 doi: 10.1007/s11684-022-0965-7

摘要: Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

关键词: pregnancy     IgG glycome     type I interferon     systemic lupus erythematosus    

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

null

《医学前沿(英文)》 2017年 第11卷 第4期   页码 480-489 doi: 10.1007/s11684-017-0594-8

摘要:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

关键词: human immunodeficiency virus type I     superinfection     incidence     immune response    

High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

《化学科学与工程前沿(英文)》 2007年 第1卷 第4期   页码 399-403 doi: 10.1007/s11705-007-0073-x

摘要: The present work focused on the high expression of recombinant human consensus interferon- (cIFN) by Pichia pastoris. The cycle of glycerol feeding, the strategy of methanol feeding and the optimum pH for protein induction were studied. The optimized strategies were a 4-h glycerol-feeding period, induction pH being kept at 5.0 and methanol concentration being kept under 5 g/L. The maximum dry cell weight, cIFN production and bioactivity obtained were 168, 1.24 g/L and 5.4×10 U/mL, respectively.

关键词: bioactivity     pastoris     maximum     induction     optimized    

通过<i> B i>位Ta置换对<i> AB i> O4型EuNbO4的热学和力学性质进行优化 Article

陈琳, 冯晶

《工程(英文)》 2020年 第6卷 第2期   页码 177-184 doi: 10.1016/j.eng.2019.12.006

摘要:

铁弹性的ABO4型RETaO4陶瓷和RENbO4陶瓷(RE表示稀土)是具有潜在应用价值的热障涂层(TBC)材料,研究人员正在对其进行大量研究。结果显示, RETaO4陶瓷的力学性质优于RENbO4陶瓷的力学性质。在本研究中,我们通过B位钽(Ta)置换对利用固相法(SSR)制备的EuNbO4陶瓷的热学和力学性质进行优化。我们使用X射线衍射(XRD)法和拉曼光谱技术对所制备的晶体结构进行确认,并利用扫描电子显微镜(SEM)对结构表面的微观形貌进行观察。结果表明,通过B位Ta置换可以有效提高EuNbO4陶瓷的杨氏模量和热膨胀系数(TEC),且其最大值分别为169 GPa和1.12×10−5 K−1(1200 ℃); EuNbO4陶瓷的热导率被降低至1.52 W·K–1·m–1(700 ℃),且材料的抗热辐射能力得到了改善。我们建立了声子热扩散系数与温度之间的关系,用以通过消除热辐射效应来确定声子本征热导率。研究结果表明,通过B位Ta置换能够有效优化EuNbO4的热学和力学性质,从而使得此种材料在将来可成为一种高温结构陶瓷材料。

关键词: 热障涂层,稀土铌酸盐,置换,热导率,热膨胀系数,杨氏模量    

Phase separation in cGAS-STING signaling

《医学前沿(英文)》 2023年 第17卷 第5期   页码 855-866 doi: 10.1007/s11684-023-1026-6

摘要: Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.

关键词: biomolecular condensates     phase separation     cGAS-STING pathway     cGAS     STING     cGAMP     interferon    

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

《医学前沿(英文)》 2022年 第16卷 第1期   页码 17-24 doi: 10.1007/s11684-021-0873-2

摘要: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is a kind of human glucagon-like peptide-1 (GLP-1) analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism. GLP-1 can also delay stomach emptying and suppress appetite to help lose weight. This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.

关键词: semaglutide     type 2 diabetes     obesity    

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿(英文)》 2019年 第13卷 第2期   页码 238-249 doi: 10.1007/s11684-017-0599-3

摘要: The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) ( =24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.

关键词: interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

Personalized medicine of type 2 diabetes

null

《医学前沿(英文)》 2013年 第7卷 第1期   页码 1-3 doi: 10.1007/s11684-013-0241-y

Metabolomics in human type 2 diabetes research

null

《医学前沿(英文)》 2013年 第7卷 第1期   页码 4-13 doi: 10.1007/s11684-013-0248-4

摘要:

The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.

关键词: metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

《医学前沿(英文)》 2019年 第13卷 第4期   页码 427-437 doi: 10.1007/s11684-018-0672-6

摘要: Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized by locally infiltrative but rarely metastatic lesions. Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF. The use of these drugs, however, is mainly based on the recommendations of retrospective studies with small sample sizes. Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF were reviewed to provide references for clinical applications and research. The efficacy and safety of targeted therapy were compared with those of other systemic therapy options. Targeted therapy does not provide considerable advantages in efficacy and safety over other medical treatments and is usually applied after the failure of antihormonal therapies, nonsteroidal anti-inflammatory drugs, and chemotherapy. Further studies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy of DF.

关键词: targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

The mechanisms linking adiposopathy to type 2 diabetes

null

《医学前沿(英文)》 2013年 第7卷 第4期   页码 433-444 doi: 10.1007/s11684-013-0288-9

摘要:

Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.

关键词: obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

《能源前沿(英文)》 2009年 第3卷 第4期   页码 414-422 doi: 10.1007/s11708-009-0038-5

摘要: An axial-type fan that operates at a relative total pressure of 671Pa and a static pressure of 560Pa with a flowrate of 416.6m/min is developed using an optimization technique based on the gradient method. Prior to the optimization of the fan blade, a three-dimensional axial-type fan blade is designed based on the free-vortex method along the radial direction. Twelve design variables are applied to the optimization of the rotor blade, and one design variable is selected for optimizing a stator which is located behind the rotor to support a fan-driving motor. The total and static pressure are applied to the restriction condition with the operating flowrate on the design point, and the efficiency is chosen as the response variable to be maximized. Through these procedures, an initial axial-fan blade designed by the free vortex method is modified to increase the efficiency with a satisfactory operating condition. The optimized fan is tested and compared with the performance obtained with the same class fan to figure out the optimization effect. The test results show that the optimized fan not only satisfies the restriction conditions but also operates at the same efficiency even though the tip clearance of the optimized fan is greater than 30%. The experimental and numerical tests show that this optimization method can improve the efficiency and operating pressures on axial-type fans.

关键词: axial-type fan     gradient method     free-vortex method     design variable     total pressure     static pressure     operating flowrate    

Mechanical performance analysis and stiffness test of a new type of suspension bridge

《结构与土木工程前沿(英文)》 2021年 第15卷 第5期   页码 1160-1180 doi: 10.1007/s11709-021-0760-6

摘要: A new type of suspension bridge is proposed based on the gravity stiffness principle. Compared with a conventional suspension bridge, the proposed bridge adds rigid webs and cross braces. The rigid webs connect the main cable and main girder to form a truss that can improve the bending stiffness of the bridge. The cross braces connect the main cables to form a closed space truss structure that can improve the torsional stiffness of the bridge. The rigid webs and cross braces are installed after the construction of a conventional suspension bridge is completed to resist different loads with different structural forms. A new type of railway suspension bridge with a span of 340 m and a highway suspension bridge with a span of 1020 m were designed and analysed using the finite element method. The stress, deflection of the girders, unbalanced forces of the main towers, and natural frequencies were compared with those of conventional suspension bridges. A stiffness test was carried out on the new type of suspension bridge with a small span, and the results were compared with those for a conventional bridge. The results showed that the new suspension bridge had a better performance than the conventional suspension bridge.

关键词: new type of suspension bridge     stiffness test     mechanical performance     railway bridge     space truss    

Influences of spinel type and polymeric surfactants on the size evolution of colloidal magnetic nanocrystals

Tahereh R. BASTAMI,Mohammad H. ENTEZARI,Chiwai KWONG,Shizhang QIAO

《化学科学与工程前沿(英文)》 2014年 第8卷 第3期   页码 378-385 doi: 10.1007/s11705-014-1441-y

摘要: Two types of polymeric surfactants, PEG and PVP , were used for the preparation of magnetic ferrite MFe O (M= Mn, Fe) colloidal nanocrystals using a solvothermal reaction method. The effect of spinel type effect on the size evolution of various nanoparticles was investigated. It was found that Fe O nanoparticles exhibited higher crystalinity and size evolution than MnFe O nanoparticles with use of the two surfactants. It is proposed that this observation is due to fewer tendencies of surfactants on the surface of Fe O building blocks nanoparticles than MnFe O . Less amounts of surfactant or capping agent on the surface of nanoparticles lead to the higher crystalibity and larger size. It is also suggested that the type of spinel (normal or inverted spinel) plays a key role on the affinity of the polymeric surfactant on the surface of building blocks.

关键词: spinel type     polymeric surfactant     size evolution     mangnetic ferrite nanoparticle    

Coulomb-type solutions for passive earth pressure with steady seepage

WANG Junjie, CHAI Hejun, LIN Xin, XU Jiamei

《结构与土木工程前沿(英文)》 2008年 第2卷 第1期   页码 56-66 doi: 10.1007/s11709-008-0001-2

摘要: Present paper deals with the computing of passive earth pressure acting on the vertical rigid retaining wall supporting the soil mass subjected to water seepage. The basic assumptions of Coulomb’s theory and the 2-dimensional steady flow function are used. Three Coulomb-type solutions for the passive earth pressures are presented for the walls provided with three different drainage systems respectively. Based on the general solutions, the variations of the critical inclination of the failure surface and the coefficient of passive earth pressure with increasing the effective friction angle of the soil mass, the soil/structure friction angle, and the water/soil unit weight ratio are discussed. Two tables with values of the coefficients of passive earth pressure for Cases 1 and 3 respectively are also presented.

关键词: function     coefficient     Coulomb-type     effective friction     different drainage    

标题 作者 时间 类型 操作

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

期刊论文

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

null

期刊论文

High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

期刊论文

通过<i> B i>位Ta置换对<i> AB i> O4型EuNbO4的热学和力学性质进行优化

陈琳, 冯晶

期刊论文

Phase separation in cGAS-STING signaling

期刊论文

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

期刊论文

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

期刊论文

Personalized medicine of type 2 diabetes

null

期刊论文

Metabolomics in human type 2 diabetes research

null

期刊论文

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

期刊论文

The mechanisms linking adiposopathy to type 2 diabetes

null

期刊论文

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

期刊论文

Mechanical performance analysis and stiffness test of a new type of suspension bridge

期刊论文

Influences of spinel type and polymeric surfactants on the size evolution of colloidal magnetic nanocrystals

Tahereh R. BASTAMI,Mohammad H. ENTEZARI,Chiwai KWONG,Shizhang QIAO

期刊论文

Coulomb-type solutions for passive earth pressure with steady seepage

WANG Junjie, CHAI Hejun, LIN Xin, XU Jiamei

期刊论文