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Nitrogen removal efficiencies and microbial communities in full-scale IFAS and MBBR municipal wastewater treatment plants at high COD:N ratio

Supaporn Phanwilai, Naluporn Kangwannarakul, Pongsak (Lek) Noophan, Tamao Kasahara, Akihiko Terada, Junko Munakata-Marr, Linda Ann Figueroa

《环境科学与工程前沿（英文）》 2020年第14卷第6期 doi: 10.1007/s11783-020-1374-2

摘要： Abstract • Two IFAS and two MBBR full-scale systems (high COD:N ratio 8:1) were characterized. • High specific surface area carriers grew and retained slow-growing nitrifiers. • High TN removal is related to high SRT and low DO concentration in anoxic tanks. The relative locations of AOB, NOB, and DNB were examined for three different kinds of carriers in two types of hybrid biofilm process configurations: integrated fixed-film activated sludge (IFAS) and moving bed biofilm reactor (MBBR) processes. IFAS water resource recovery facilities (WRRFs) used AnodkalnessTM K1 carriers (KC) at Broomfield, Colorado, USA and polypropylene resin carriers (RC) at Fukuoka, Japan, while MBBR WRRFs used KC carriers at South Adams County, Colorado, USA and sponge carriers (SC) at Saga, Japan. Influent COD to N ratios ranged from 8:1 to 15:1. The COD and BOD removal efficiencies were high (96%–98%); NH4+-N and TN removal efficiencies were more varied at 72%–98% and 64%–77%, respectively. The extent of TN removal was higher at high SRT, high COD:N ratio and low DO concentration in the anoxic tank. In IFAS, RC with high specific surface area (SSA) maintained higher AOB population than KC. Sponge carriers with high SSA maintained higher overall bacteria population than KC in MBBR systems. However, the DNB were not more abundant in high SSA carriers. The diversity of AOB, NOB, and DNB was fairly similar in different carriers. Nitrosomonas sp. dominated over Nitrosospira sp. while denitrifying bacteria included Rhodobacter sp., Sulfuritalea sp., Rubrivivax sp., Paracoccus sp., and Pseudomonas sp. The results from this work suggest that high SRT, high COD:N ratio, low DO concentration in anoxic tanks, and carriers with greater surface area may be recommended for high COD, BOD and TN removal in WRRFs with IFAS and MBBR systems.

关键词： IFAS MBBR Anodkalness^TM K1 carrier Polypropylene resin carrier Sponge carrier

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K+sup> and Na+sup> fluxes in roots of two Chinese Iris populations

Pinfang LI,Biao ZHANG

《农业科学与工程前沿（英文）》 2014年第1卷第2期页码 144-149 doi: 10.15302/J-FASE-2014016

摘要： Maintenance of ion homeostasis, particularly the regulation of K and Na uptake, is important for all plants to adapt to salinity. Observations on ionic response to salinity and net fluxes of K , Na in the root exhibited by plants during salt stress have highlighted the need for further investigation. The objectives of this study were to compare salt adaptation of two Chinese Iris ( Pall. var. (Fisch.) Koidz.) populations, and to improve understanding of adaptation to salinity exhibited by plants. Plants used in this study were grown from seeds collected in the Xinjiang Uygur Autonomous Region (Xj) and Beijing Municipality (Bj), China. Hydroponically-grown seedlings of the two populations were supplied with nutrient solutions containing 0.1 (control) and 140 mmol·L NaCl. After 12 days, plants were harvested for determination of relative growth rate and K , Na concentrations. Net fluxes of K , Na from the apex and along the root axis to 10.8 mm were measured using non-invasive micro-test technique. With 140 mmol·L NaCl treatment, shoots for population Xj had larger relative growth rate and higher K concentration than shoots for population Bj. However, the Na concentrations in both shoots and roots were lower for Xj than those for Bj. There was a lower net efflux of K found in population Xj than by Bj in the mature zone (approximately 2.4-10.8 mm from root tip). However, no difference in the efflux of Na between the populations was obtained. Population Xj of continued to grow normally under NaCl stress, and maintained a higher K /Na ratio in the shoots. These traits, which were associated with lower K leakage, help population Xj adapt to saline environments.

关键词： Iris lactea Pall. var. chinensis (Fisch.) Koidz population K⁺ and Na⁺ ion flux non-invasive micro-test technique

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Symbiotic performance, shoot biomass and water-use efficiency of three groundnut (

Sofiya K. MUHABA, Felix D. DAKORA

《农业科学与工程前沿（英文）》 2020年第7卷第4期页码 455-466 doi: 10.15302/J-FASE-2020354

摘要：

Phosphorus is a key nutrient element involved in energy transfer for cellular metabolism, respiration and photosynthesis and its supply at low levels can affect legume nodulation, N fixation, and C assimilation. A two-year field study was conducted in Ethiopia in 2012 and 2013 to evaluate the effects of P supply on growth, symbiotic N nutrition, grain yield and water-use efficiency of three groundnut genotypes. Supplying P to the genotypes significantly increased their shoot biomass, symbiotic performance, grain yield, and C accumulation. There was, however, no effect on shoot δ C values in either year. Compared to the zero-P control, supplying 40 kg·ha P markedly increased shoot biomass by 77% and 66% in 2012 and 2013, respectively. In both years, groundnut grain yields were much higher at 20 and 30 kg·ha P. Phosphorus supply markedly reduced shoot δ N values and increased the %Ndfa and amount of N-fixed, indicating the direct involvement of P in promoting N fixation in nodulated groundnut. The three genotypes differed significantly in δ N, %Ndfa, N-fixed, grain yield, C concentration, and δ C. The phosphorus × genotype interaction was also significant for shoot DM, N content, N-fixed and soil N uptake.

关键词： shoot yield N-fixed %Ndfa δ¹⁵N δ¹³C water-use efficiency

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Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation

HIXSON PhD, Chung-Shiuan CHEN MS8sup>, Paul K. WHELTON MD, MSc9sup>,

《医学前沿（英文）》 2010年第4卷第1期页码 59-66 doi: 10.1007/s11684-010-0015-8

摘要： Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes. However, blood pressure (BP) responses to potassium supplementation vary among individuals. This study was designed to examine the association between 12 single nucleotide polymorphisms (SNPs) in the adducin 1 alpha (ADD1) and guanine nucleotide binding protein (G protein) beta polypeptide 3 (GNB3) genes and systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) responses to potassium-supplementation. We conducted a 7-day high-sodium intervention (307.8 mmol sodium/day) followed by a 7-day high-sodium with potassium-supplementation (60 mmol potassium/day) among 1906 Han Chinese participants from rural north China. BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer. We identified significant associations between ADD1 variant rs17833172 and SBP, DBP, and MAP responses to potassium-supplementation (all <0.0001) that remained significant after adjustment for multiple comparisons. In participants that were heterozygous or homozygous for the G allele of this marker, SBP, DBP, and MAP response to potassium-supplementation were −3.52 (−3.82, −3.21), −1.41 (−1.66, −1.15) and −2.12 (−2.37, −1.87), respectively, as compared to the corresponding responses of 1.99 (0.25, 3.73), −0.65 (−0.10, −0.21), and −0.23 (−0.37, 0.83), respectively, for those who were homozygous for A allele. In addition, participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation ( = 0.0041 and 0.01, respectively), which was also significant after correction for multiple testing. DBP and MAP responses to potassium-supplementation were −1.36 (−1.63, −1.10) and −2.07 (−2.32, −1.82) for those with at least G allele compared to corresponding responses of 0.86 (−0.68, 2.40) and −0.45 (−1.74, 0.84) for those who were homozygous for A allele. In summary, our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation, which could have important clinical and public health implications. Future studies aimed at replicating these novel findings are warranted.

关键词： blood pressure genetics polymorphism die-tary potassium potassium sensitivity adducin 1 alpha (ADD1) guanine nucleotide binding protein beta polypeptide 3 (GNB3)

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动态二叉树表示环境的A*sup>算法及其在足球机器人路径规划中的实现

唐平,杨宜民

《中国工程科学》 2002年第4卷第9期页码 50-53

摘要：

提出采用二叉树表示二维空间的方法，对全局路径规划和局部路径规划进行综合考虑，设计移动机器人在复杂环境下对动态障碍物进行避障的A*sup>算法。

关键词：动态二叉树 A*sup>算法路径规划

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Clinical significance of CD34+sup>CD117dimsup>/CD34+sup>CD117brisup> myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

《医学前沿（英文）》 2021年第15卷第4期页码 608-620 doi: 10.1007/s11684-021-0836-7

摘要： t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy with a high relapse rate in China. Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21) AML, and CD34 CD117 cell proportion was determined as an independent factor for this disease outcome. Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21) AML clinical prognosis. In this study, 85 patients with t(8;21) AML were enrolled. The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genes ( , , and ) were measured using quantitative reverse transcription PCR. Associations between gene expression and clinical outcomes were determined using Cox regression models. Results showed that patients with high , , or expression had significantly inferior overall survival (OS), whereas those with high or expression showed relatively favorable prognosis. Univariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual disease (MRD), and expression levels of , , , and were associated with OS. Multivariate analysis indicated that mutation, MRD and and expression levels were independent prognostic variables for OS. Identifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21) AML.

关键词： t(8 21)(q22 q22) AML CD34⁺CD117^dim/ CD34⁺CD117^bri cell population gene expression prognosis

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新型400 km·h−1sup> 级架空接触网监测技术

Chul Jin Cho, Young Park

《工程（英文）》 2016年第2卷第3期页码 360-365 doi: 10.1016/J.ENG.2016.03.016

摘要：

近年来，高速铁路各项技术不断发展，列车运行速度从300 km•h–1 提高到400 km•h−1sup>。本文介绍了由韩国研究者开发和论证的技术，即400 km•h−1sup> 级集电性能评估方法。

关键词：高速铁路架空接触网状态监测基于图像处理的测量方式

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Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification

《环境科学与工程前沿（英文）》 2023年第17卷第6期 doi: 10.1007/s11783-023-1674-4

摘要：

● Simultaneous NH₄⁺/NO₃^– removal was achieved in the FeS denitrification system

关键词： Anammox Denitrification FeS NH₄⁺/NO₃⁻ Sulfammox

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High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

《化学科学与工程前沿（英文）》 2015年第9卷第3期页码 376-380 doi: 10.1007/s11705-015-1531-5

摘要： The Chinese Hamster Ovary (CHO K1) cell was used to express a targeted anti-cancer monoclonal antibody by optimizing the platform of the construction of production cell line in this study. The adherent CHO K1 was first adapted to suspension culture in chemical defined medium. Then the glutamine synthetase (GS) vector was applied to construct a single plasmid to overexpress a monoclonal antibody IgG1. Post transfection, the production of cell pool was optimized by glutamine-free selection and amplification using various concentrations of methionine sulfoximine. The best cell pool of CHO K1/IgG1 was used to screen the top single clone using the limiting dilution cloning. Finally, a high IgG1 production of 780 mg/L was obtained from a batch culture. This study demonstrated that the construction of high producing cell line, from gene to clone, could be completed within six month and the gene amplification improved protein production greatly.

关键词： Chinese hamster ovary (CHO) monoclonal antibody IgG1 amplification cell line development

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Advances of 12thsup> CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

《化学科学与工程前沿（英文）》 2021年第15卷第3期页码 461-463 doi: 10.1007/s11705-020-2026-6

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RNA m6sup>A modification and its function in diseases

null

《医学前沿（英文）》 2018年第12卷第4期页码 481-489 doi: 10.1007/s11684-018-0654-8

摘要：

N⁶-methyladenosine (m⁶A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m⁶A modification could be installed by m⁶A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m⁶A “erasers” (FTO and ALKBH5). The function of m⁶A is executed by m⁶A “readers” that bind to m⁶A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m⁶A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m⁶A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m⁶A are still largely unknown. Moreover, investigations of the m⁶A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m⁶A research and highlight the functional relevance and importance of m⁶A modification in in vitro cell lines, in physiological contexts, and in cancers.

关键词： RNA modification m⁶A immunity cancer epigenetics

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Impact of H₂S on Hg0sup> capture performance over nitrogen-doped carbon microsphere

《化学科学与工程前沿（英文）》 2024年第18卷第3期 doi: 10.1007/s11705-024-2396-2

摘要： A nitrogen-doped carbon microsphere sorbent with a hierarchical porous structure was synthesized via aggregation-hydrothermal carbonization. The Hg⁰ adsorption performance of the nitrogen-doped carbon microsphere sorbent was tested and compared with that of the coconut shell activated carbon prepared in the laboratory. The effect of H₂S on Hg⁰ adsorption was also investigated. The nitrogen-doped carbon microsphere sorbent exhibited superior mercury removal performance compared with that of coconut shell activated carbon. In the absence of H₂S at a low temperature (≤ 100 °C), the Hg⁰ removal efficiency of the nitrogen-doped carbon microsphere sorbent exceeded 90%. This value is significantly higher than that of coconut shell activated carbon, which is approximately 45%. H₂S significantly enhanced the Hg⁰ removal performance of the nitrogen-doped carbon microsphere sorbent at higher temperatures (100–180 °C). The hierarchical porous structure facilitated the diffusion and adsorption of H₂S and Hg⁰, while the nitrogen-containing active sites significantly improved the adsorption and dissociation capabilities of H₂S, contributing to the generation of more active sulfur species on the surface of the nitrogen-doped carbon microsphere sorbent. The formation of active sulfur species and HgS on the sorbent surface was further confirmed using X-ray photoelectron spectroscopy and Hg⁰ temperature-programmed desorption tests. Density functional theory was employed to elucidate the adsorption and transformation of Hg⁰ on the sorbent surface. H₂S adsorbed and dissociated on the sorbent surface, generating active sulfur species that reacted with gaseous Hg⁰ to form HgS.

关键词： nitrogen-doped carbon microsphere H₂S Hg⁰ removal adsorption mechanism

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Enhanced photocatalytic performance by regulating the Ce/Ce ratio in cerium dioxide

《化学科学与工程前沿（英文）》 2024年第18卷第3期 doi: 10.1007/s11705-024-2394-4

摘要： Cerium dioxide (CeO₂) photocatalysts are used in treating environmental pollution and addressing the energy crisis due to their excellent oxygen storage capacities and abundant oxygen vacancies. In this paper, CeO₂ precursors were synthesized with different water-alcohol ratios via a solvothermal method, and CeO₂ photocatalysts with different Ce³⁺/Ce⁴⁺ ratios were obtained by changing the precursor calcination atmospheres (air, Ar) as well as the calcination time. The effects of CeO₂ with different Ce³⁺/Ce⁴⁺ ratios in photocatalytic degradations of methylene blue under visible light were investigated. X-ray photoelectron spectroscopy results showed that the surfaces of the samples calcined under Ar had higher Ce³⁺/Ce⁴⁺ ratios and oxygen vacancy concentrations, which reduced the band gaps of the catalysts and improved their utilization of visible light. In addition, the many Ce³⁺/Ce⁴⁺ redox centers and oxygen vacancies on the sample surfaces improved the separation and transfer efficiencies of the photogenerated carriers. The sample C2-Ar calcined under Ar showed a high adsorption capacity and excellent photocatalytic activity by removing 96% of the methylene blue within 120 min, which was more than twice the degradation rate of the sample (C2-air) prepared via calcination under air. Trapping experiments showed that photogenerated holes played a key role in the photocatalytic process. In addition, a synergistic photocatalytic mechanism for the Ce³⁺/Ce⁴⁺ redox centers and oxygen vacancies was elucidated in detail, and the sensitization of cerium dioxide by dyes aided the degradation of methylene blue.

关键词： CeO₂ oxygen vacancies Ce³⁺/Ce⁴⁺ ratios photocatalytic dye-sensitization

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Selective recovery of Cu

Haiping LUO,Bangyu QIN,Guangli LIU,Renduo ZHANG,Yabo TANG,Yanping HOU

《环境科学与工程前沿（英文）》 2015年第9卷第3期页码 522-527 doi: 10.1007/s11783-014-0633-5

摘要： As the bioelectrochemical system, the microbial fuel cell (MFC) and the microbial electrolysis cell (MEC) were developed to selectively recover Cu and Ni ions from wastewater. The wastewater was treated in the cathode chambers of the system, in which Cu and Ni ions were removed by using the MFC and the MEC, respectively. At an initial Cu concentration of 500 mg·L , removal efficiencies of Cu increased from 97.0%±1.8% to 99.0%±0.3% with the initial Ni concentrations from 250 to 1000 mg·L , and maximum power densities increased from 3.1±0.5 to 5.4±0.6 W·m . The Ni removal mass in the MEC increased from 6.8±0.2 to 20.5±1.5 mg with the increase of Ni concentrations. At an initial Ni concentration of 500 mg·L , Cu removal efficiencies decreased from 99.1%±0.3% to 74.2%±3.8% with the initial Cu concentrations from 250 to 1000 mg·L , and maximum power densities increased from 3.0±0.1 to 6.3±1.2 W·m . Subsequently, the Ni removal efficiencies decreased from 96.9%±3.1% to 73.3%±5.4%. The results clearly demonstrated the feasibility of selective recovery of Cu and Ni from the wastewater using the bioelectrochemical system.

关键词： bioelectrochemical system Cu²⁺ Ni²⁺ selective recovery

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Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

《医学前沿（英文）》 2024年第18卷第2期页码 285-302 doi: 10.1007/s11684-023-1035-5

摘要： Amyotrophic lateral sclerosis (ALS) is a progressive neurogenerative disorder with uncertain origins. Emerging evidence implicates N6-methyladenosine (m⁶A) modification in ALS pathogenesis. Methylated RNA immunoprecipitation sequencing (MeRIP-seq) and liquid chromatography–mass spectrometry were utilized for m⁶A profiling in peripheral immune cells and serum proteome analysis, respectively, in patients with ALS (n = 16) and controls (n = 6). The single-cell transcriptomic dataset (GSE174332) of primary motor cortex was further analyzed to illuminate the biological implications of differentially methylated genes and cell communication changes. Analysis of peripheral immune cells revealed extensive RNA hypermethylation, highlighting candidate genes with differential m⁶A modification and expression, including C-X3-C motif chemokine receptor 1 (CX3CR1). In RAW264.7 macrophages, disrupted CX3CR1 signaling affected chemotaxis, potentially influencing immune cell migration in ALS. Serum proteome analysis demonstrated the role of dysregulated immune cell migration in ALS. Cell type-specific expression variations of these genes in the central nervous system (CNS), particularly microglia, were observed. Intercellular communication between neurons and glial cells was selectively altered in ALS CNS. This integrated approach underscores m⁶A dysregulation in immune cells as a potential ALS contributor.

关键词： amyotrophic lateral sclerosis N⁶-methyladenosine epi-transcriptome proteome single cell RNA sequencing analysis CX3CR1

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标题作者时间类型操作

Nitrogen removal efficiencies and microbial communities in full-scale IFAS and MBBR municipal wastewater treatment plants at high COD:N ratio

Supaporn Phanwilai, Naluporn Kangwannarakul, Pongsak (Lek) Noophan, Tamao Kasahara, Akihiko Terada, Junko Munakata-Marr, Linda Ann Figueroa

期刊论文

K+sup> and Na+sup> fluxes in roots of two Chinese Iris populations

Pinfang LI,Biao ZHANG

期刊论文

Symbiotic performance, shoot biomass and water-use efficiency of three groundnut (

Sofiya K. MUHABA, Felix D. DAKORA

期刊论文

Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation

HIXSON PhD, Chung-Shiuan CHEN MS8sup>, Paul K. WHELTON MD, MSc9sup>,

期刊论文

动态二叉树表示环境的A*sup>算法及其在足球机器人路径规划中的实现

唐平,杨宜民

期刊论文

Clinical significance of CD34+sup>CD117dimsup>/CD34+sup>CD117brisup> myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

期刊论文

新型400 km·h−1sup> 级架空接触网监测技术

Chul Jin Cho, Young Park

期刊论文

Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification

期刊论文

High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

期刊论文

Advances of 12thsup> CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

期刊论文

RNA m6sup>A modification and its function in diseases

null

期刊论文

Impact of H₂S on Hg0sup> capture performance over nitrogen-doped carbon microsphere

期刊论文

Enhanced photocatalytic performance by regulating the Ce/Ce ratio in cerium dioxide

期刊论文

Selective recovery of Cu

Haiping LUO,Bangyu QIN,Guangli LIU,Renduo ZHANG,Yabo TANG,Yanping HOU

期刊论文

Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

期刊论文

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