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Obesity in China: its characteristics, diagnostic criteria, and implications

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 129-133 doi: 10.1007/s11684-015-0387-x

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Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

《医学前沿（英文）》 2012年 第6卷 第3期   页码 243-247 doi: 10.1007/s11684-012-0201-y

摘要： Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

关键词： LADA     diagnostic criteria     autoantibodies     insulin independence     age of diagnosis    

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临床诊断标准实施和全城症状排查对武汉新冠病毒肺炎疫情防控的效果评价 Article

魏永越, 魏良敏, 姜玥, 沈思鹏, 赵杨, 郝元涛, 杜志成, 唐金陵, 张志杰, 姜庆五, 李立明, 陈峰, 沈洪兵

《工程（英文）》 2020年 第6卷 第10期   页码 1141-1146 doi: 10.1016/j.eng.2020.04.008

摘要：

自新型冠状病毒肺炎（coronavirus disease 2019, COVID-19）疫情发生以来，中国大多数的病例集中在武汉市。虽然早期病例数和死亡人数迅速增加，但通过采取多种防控措施，疫情得以快速遏制。纵观全球，疫情已蔓延至全球六大洲的187个国家，确诊病例数已超过300万，这一数字仍在快速增长。在此特殊背景下，有必要对我国疫情防控措施开展科学的、定量的评估，为全球疫情防控提供决策依据。为此，本研究评估了临床诊断标准实施和全城症状排查对武汉市疫情控制的贡献。考虑COVID-19的传播机理、隔离措施等，建立SEIR+Q传播动力学模型。基于武汉市截至2020年2月14日官方公布的每日确诊病例数和未确诊的临床诊断病例数进行建模，并预测2月14日以后的疫情态势。基于实际疫情数据，与模型预测趋势相比较，评价防控措施效果。结果显示，若维持2月14日以前防控措施不变，那么预测将于3月25日和4月29日，每日新增病例数分别降至100例和10例以下，将于5月31日首次现零。而事实上，截至3月6日，武汉市每日新增病例数降至100例以下，截至3月11日降至10例以下，3月18日首次实现零增长，较之模型预测结果分别提前了19 d、49 d和74 d。截至3月30日，实际累计病例数为50 006例，比模型预测值减少19 951例。有效再生数[effective reproductive number, R(t)]分析显示，2月6−10日的第一次全城症状排查后，R(t)显现出下降趋势，2月12−14日的临床诊断标准实施和2月17−19日的第二次全城症状排查后，R(t)显现出较大的降幅，与实际情况较为一致。综上所述，武汉市临床诊断标准的实施和全城症状排查等综合防控措施成效显著，可为世界各国的疫情防控决策提供科学依据。

关键词： COVID-19     SEIR+Q传染病动力学模型     临床诊断标准     全城症状排查     干预效果评价    

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Trapezoidal Intuitionistic Fuzzy Aggregation Operator Based on Choquet Integral and Its Application to Multi-Criteria

Xi-hua Li,Xiao-hong Chen

《工程管理前沿（英文）》 2015年 第2卷 第3期   页码 266-276 doi: 10.15302/J-FEM-2015048

摘要： The Choquet integral can serve as a useful tool to aggregate interacting criteria in an uncertain environment. In this paper, a trapezoidal intuitionistic fuzzy aggregation operator based on the Choquet integral is proposed for multi-criteria decision-making problems. The decision information takes the form of trapezoidal intuitionistic fuzzy numbers and both the importance and the interaction information among decision-making criteria are considered. On the basis of the introduction of trapezoidal intuitionistic fuzzy numbers, its operational laws and expected value are defined. A trapezoidal intuitionistic fuzzy aggregation operator based on the Choquet integral is then defined and some of its properties are investigated. A new multi-criteria decision-making method based on a trapezoidal intuitionistic fuzzy Choquet integral operator is proposed. Finally, an illustrative example is used to show the feasibility and availability of the proposed method.

关键词： multi-criteria decision making     trapezoidal intuitionistic fuzzy numbers     Choquet integral     fuzzy measure     aggregation operator    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

《医学前沿（英文）》 2022年 第16卷 第5期   页码 723-735 doi: 10.1007/s11684-021-0905-y

摘要： Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. At present, no definite ALS biomarkers are available. In this study, exosomes from the plasma of patients with ALS and healthy controls were extracted, and differentially expressed exosomal proteins were compared. Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controls. CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice. CORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, and autophagic protein expression were evaluated. CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy, and hindered the formation of autolysosomes. Moreover, CORO1A activated Ca2+-dependent phosphatase calcineurin, thereby blocking the fusion of autophagosomes and lysosomes. The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes. In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

关键词： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Selection of digital fabrication technique in the construction industry—A multi-criteria decision-making

《结构与土木工程前沿（英文）》 doi: 10.1007/s11709-024-1075-1

摘要： Digital fabrication techniques, in recent decades, have provided the basis of a sustainable revolution in the construction industry. However, selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex problem. This paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making technique. The alternatives considered in the study are concrete three-dimensional (3D) printing, shotcrete, smart dynamic casting, material intrusion, mesh molding, injection concrete 3D printing, and thin forming techniques. The criteria include formwork utilization, reinforcement incorporation, geometrical complexity, material enhancement, assembly complexity, surface finish, and build area. It demonstrates different multi-criteria decision-making techniques, with both subjective and objective weighting methods. The given ranking is based on the current condition of digital fabrication in the construction industry. The study reveals that in the selection of digital fabrication techniques, the criteria including reinforcement incorporation, build area, and geometrical complexity play a pivotal role, collectively accounting for nearly 70% of the overall weighting. Among the evaluated techniques, concrete 3D printing emerged as the best performer, however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication     multicriteria decision-making     concrete 3D printing    

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Finite element analysis of stress concentrations and failure criteria in composite plates with circular

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 281-294 doi: 10.1007/s11465-014-0307-9

摘要：

In this study, the stress concentration factors (SCF) in cross-and-angle-ply laminated composite plates as well as in isotropic plates with single circular holes subjected to uniaxial loading is studied. A quadrilateral finite element of four-node with 32 degrees of freedom at each node, previously developed for the bending and mechanical buckling of laminated composite plates, is used to evaluate the stress distribution in laminated composite plates with central circular holes. Based up on the classical plate theory, the present finite element is a combination of a linear isoparametric membrane element and a high precision rectangular Hermitian element. The numerical results obtained by the present element compare favorably with those obtained by the analytic approaches published in literature. It is observed that the obtained results are very close to the reference results, which demonstrates the accuracy of the present element. Additionally, to determine the first ply failure (FPF) of laminated plate, several failure criterions are employed. Finally, to show the effect of ratio on the failure of plates, a number of figures are given for different fiber orientation angles.

关键词： laminated composite plates     stress concentration     geometric singularity     anisotropic effect    

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Concepts and implementation of strain-based criteria in design codes for steel structures

Reidar BJORHOVDE

《结构与土木工程前沿（英文）》 2012年 第6卷 第3期   页码 210-216 doi: 10.1007/s11709-012-0165-7

摘要： A uniaxial tension test is commonly used to determine the mechanical properties of steel, but it has no meaning for the response of the material in a structure. The test was developed as a consensus solution by producers, fabricators, designers and code writers, to have a standard by which similar materials could be compared to a common base. It does not represent the actual behavior of the steel in a structure, and was never intended to do so. To study the true behavior of the structure and how the material responds it would be better to determine the strains and deformations that will take place during actual service condition. Such characteristics reflect the real behavior, whether in the elastic or inelastic range. If stresses or forces are needed, these are easily determined by the value of the strain and the relevant material modulus, along with the type of cross section, whether elastic or inelastic. The paper addresses the properties of a range of structural steels, how these are incorporated into design standards and how the standards define deformation characteristics and demands for bolted and welded connections.

关键词： steel     stress-strain characteristics     tension test     strain design     actual behavior     improved design codes    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

《结构与土木工程前沿（英文）》 2022年 第16卷 第7期   页码 871-881 doi: 10.1007/s11709-022-0863-8

摘要： The failure criteria of practical soil mass are very complex, and have significant influence on the safety factor of slope stability. The Coulomb strength criterion and the power-law failure criterion are classically simplified. Each one has limited applicability owing to the noticeable difference between calculated predictions and actual results in some cases. In the work reported here, an analysis method based on the least square support vector machine (LSSVM), a machine learning model, is purposefully provided to establish a complex nonlinear failure criterion via iteration computation based on strength test data of the soil, which is of more extensive applicability to many problems of slope stability. In particular, three evaluation indexes including coefficient of determination, mean absolute percentage error, and mean square error indicate that fitting precision of the machine learning-based failure criterion is better than those of the linear Coulomb criterion and nonlinear power-law criterion. Based on the proposed LSSVM approach to determine the failure criterion, the limit equilibrium method can be used to calculate the safety factor of three-dimensional slope stability. Analysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum relative errors between the proposed approach and the linear failure criterion-based method and the power-law failure criterion-based method are about 12% and 7%, respectively.

关键词： slope stability     safety factor     failure criterion     least square support vector machine    

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Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

《医学前沿（英文）》 2007年 第1卷 第1期   页码 109-114 doi: 10.1007/s11684-007-0021-7

摘要： The overall diagnostic capabilities and utility of frequency-doubling technology (FDT) in patients with primary glaucoma, which was diagnosed by standard automated perimetry (SAP) and/or optic disc appearance as the gold standard, were assessed. A comprehensive electric retrieval in MEDLINE, EMBASE, Cochrane Library, BIOSIS, Previews, HMIC, IPA, OVID, CNKI, CBMdisc, VIP information, CMCC, CCPD, SSreader, 21dmedia and manual retrieval in related textbooks, journals, congress articles and their references at home and abroad were performed to identify relevant articles in English or Chinese. The corresponding references were retrieved by means of electric retrieval and manual retrieval from different databases or materials. Criteria for inclusion or exclusion were established according to validity criteria for diagnostic studies published by the Cochrane Methods Group on Screening and Diagnostic Tests. The quality of the included articles was then assessed and characteristics were extracted. Statistical analysis was performed with Meta Test version 0.6 software to test the heterogeneity of the included articles. The appropriate effects model was selected to calculate pooled weighted sensitivity and specificity. Summary receiver operating characteristic (SROC) curve was drawn and the area under the curve (AUC) was calculated. Finally, sensitivity analysis was performed. Twenty-one studies out of 206 retrieved articles were included, with a total of 3172 patients. The reported sensitivity of FDT ranged from 0.51 to 1.00, and specificity from 0.58 to 1.00. The pooled weighted sensitivity and specificity of FDT with 95% confidence intervals (95% CI) after correction for standard error were 0.86 (0.80 0.90) and 0.87 (0.81 0.91), respectively. The AUC of SROC was 93.01%. Sensitivity analysis demonstrated no disproportionate influences of individual studies. The included articles are of good quality and FDT can be a highly efficient diagnostic test for primary glaucoma based on Meta-analysis.

关键词： inclusion     sensitivity analysis     correction     specificity     appropriate    

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海堤设防标准探讨

卢永金,,何友声,刘桦

《中国工程科学》 2005年 第7卷 第12期   页码 17-23

摘要：

调查分析了国内外海堤设防标准，把海堤破坏归结为6种模式，并分析风浪与潮位（流）对各种模式的影响，提出风浪与高潮遭遇概率粗略算法；根据海堤结构特点及其破坏模式，提出一种基于风浪与高潮遭遇概率，综合反映结构功能、使用要求与潜在风险，三层次设防的海堤设计标准，在此基础上提供了一种基于风险理论的海堤优化设计方法。

关键词： 海堤     设计标准     风浪     高潮     遭遇概率     破坏模式     风险     优化设计    

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面向机床的可重构监测诊断系统开发与应用

景敏卿,李猛,刘恒

《中国工程科学》 2013年 第15卷 第1期   页码 34-38

摘要：

提出了一种基于“系统引擎+功能组件”的监测诊断系统平台架构，并针对机床4大功能部件模块，设计了3类（振动、功率和声发射）嵌入式监测单元，以强化底层监测信息获取的实时性和灵活性。笔者还开发了一系列机床常规监测诊断组件，并针对具有特殊监测诊断需求的数控机床功能部件，开发了相应的特殊功能组件，通过对功能组件的封装和加载实现具有特定需求的机床监测诊断系统，并在秦川磨床厂和大连机床厂进行实际应用。

关键词： 机床监测诊断系统     可重构     系统引擎     功能组件    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 506-509 doi: 10.1007/s11684-013-0294-y

摘要：

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in the city of Lhasa, China. Seven out of the twenty-six hospitals registered with the Lhasa Health Bureau were included in the investigation. The entrance surface air Kerma (ESAK) of seven conventional screen-film radiology X-ray equipment in these hospitals was measured with a QA dosimeter in September 2012. The X-ray examinations were divided into three categories: PA (posterior-anterior) chest, upper/lower limb, and AP (anterior-posterior) lumbar spine. For each category, ESAKs were calculated and analyzed. The mean ESAK was 0.6 mGy for PA chest, 0.3 mGy for upper/lower limb, and 1.8 mGy for AP lumbar spine. In addition, the mean ESAK value recorded for PA chest X-ray examinations exceeded the corresponding value recommended by the International Atomic Energy Agency (0.4 mGy).

关键词： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

《医学前沿（英文）》 2022年 第16卷 第6期   页码 827-858 doi: 10.1007/s11684-022-0948-8

摘要： Infertility is experienced by 8%–12% of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable progress has been made in understanding the biology and purpose of stem cells. The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertility induced by premature ovarian insufficiency and azoospermia. Accordingly, this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs. These methods have been used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility.

关键词： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

《环境科学与工程前沿（英文）》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1475-6

摘要：

• The concentrations of 13 heavy metals in Taihu Lake were analyzed.

关键词： Heavy metals     Human health ambient water quality criteria     Taihu Lake     Health risk assessment     Contribution rate    

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标题 作者 时间 类型 操作

Obesity in China: its characteristics, diagnostic criteria, and implications

null

期刊论文

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

期刊论文

临床诊断标准实施和全城症状排查对武汉新冠病毒肺炎疫情防控的效果评价

魏永越, 魏良敏, 姜玥, 沈思鹏, 赵杨, 郝元涛, 杜志成, 唐金陵, 张志杰, 姜庆五, 李立明, 陈峰, 沈洪兵

期刊论文

Trapezoidal Intuitionistic Fuzzy Aggregation Operator Based on Choquet Integral and Its Application to Multi-Criteria

Xi-hua Li,Xiao-hong Chen

期刊论文

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

期刊论文

Selection of digital fabrication technique in the construction industry—A multi-criteria decision-making

期刊论文

Finite element analysis of stress concentrations and failure criteria in composite plates with circular

null

期刊论文

Concepts and implementation of strain-based criteria in design codes for steel structures

Reidar BJORHOVDE

期刊论文

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

期刊论文

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

期刊论文

海堤设防标准探讨

卢永金,,何友声,刘桦

期刊论文

面向机床的可重构监测诊断系统开发与应用

景敏卿,李猛,刘恒

期刊论文

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

null

期刊论文

treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

期刊论文

Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

期刊论文