资源类型

期刊论文 46

年份

2022 2

2021 1

2020 4

2019 3

2018 4

2017 1

2016 1

2015 2

2014 2

2013 6

2012 3

2011 1

2010 3

2009 4

2007 1

2006 1

2004 2

2003 2

展开 ︾

关键词

力常数 2

大规格 2

无应力长度 2

键能 2

键长 2

1860 MPa等级 1

4250 m 1

ANSYS二次开发 1

S-N曲线 1

cDNA克隆 1

不对称双连拱隧道 1

主缆索股 1

优化 1

促黄体激素（LH） 1

分阶段施工桥梁 1

剪切应力 1

半滑舌鳎 1

单元索股 1

可见光通信；游程长度受限码；有限状态机；最小汉明距离 1

展开 ︾

检索范围：

排序： 展示方式：

Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

null

《医学前沿（英文）》 2016年 第10卷 第2期   页码 191-203 doi: 10.1007/s11684-016-0450-2

摘要：

The relationship between telomere length and cancer survival has been widely studied. To gain a deeper insight, we reviewed the published studies. A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomere length in the tumor tissue. First, in the peripheral blood studies, for solid tumor patients with shortened telomere length, the combined hazard ratios (HRs) for mortality and tumor progression were 1.21 (95%CI, 1.10–1.32) and 1.71 (95%CI, 1.37–2.13), respectively. Meanwhile, in hematology malignancy, the combined HRs for mortality and tumor progression were 2.83 (95%CI, 2.14–3.74) and 2.65 (95%CI, 2.18–3.22), respectively. Second, in the studies that use tumor tissue, for patients with shortened telomeres, the combined HRs for mortality and tumor progression were 1.26 (95%CI, 0.95–1.66) and 1.65 (95%CI, 1.26–2.15), respectively. In the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, for patients with lower telomere length ratios, the combined HRs were 0.66 (95%CI, 0.53–0.83) and 0.74 (95%CI, 0.41–1.32) for mortality and tumor progression, respectively. In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival for cancer patients. However, by calculating the telomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival.

关键词： telomere     survival     cancer     meta-analysis    

HTML PDF 收藏
分享

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

null

《医学前沿（英文）》 2015年 第9卷 第4期   页码 478-486 doi: 10.1007/s11684-015-0420-0

摘要：

Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P<0.001). More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk (P<0.001), with odds ratios (95% confidence interval) equal to 2.40 (1.84–3.14), 1.36 (1.03–1.79), 1.01 (0.76–1.35), and 1.37 (1.03–1.82) for individuals in the 1st (the shortest), 2nd, 3rd, and 5th (the longest) quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.

关键词： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association study    

HTML PDF 收藏
分享

Effects of slip length and hydraulic diameter on hydraulic entrance length of microchannels with superhydrophobic

Wenchi GONG, Jun SHEN, Wei DAI, Zeng DENG, Xueqiang DONG, Maoqiong GONG

《能源前沿（英文）》 2020年 第14卷 第1期   页码 127-138 doi: 10.1007/s11708-020-0661-8

摘要： This paper investigated effects of slip length and hydraulic diameter on the hydraulic entrance length of laminar flow in superhydrophobic microchannels. Numerical investigations were performed for square microchannels with Re ranging between 0.1 and 1000. It is found that superhydrophobic microchannels have a longer hydraulic entrance length than that of conventional ones by nearly 26.62% at a low Re. The dimensionless hydraulic entrance length slightly increases with the increasing slip length at approximately Re<10, and does not vary with the hydraulic diameter. A new correlation to predict the entrance length in square microchannels with different slip lengths was developed, which has a satisfying predictive performance with a mean absolute relative deviation of 5.69%. The results not only ascertain the flow characteristics of superhydrophobic microchannels, but also suggest that super hydrophobic microchannels have more significant advantages for heat transfer enhancement at a low Re.

关键词： laminar flow     hydraulic entrance length     super hydrophobic surface     slip length     hydraulic diameter    

HTML PDF 收藏
分享

Telomeric impact of conventional chemotherapy

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 411-417 doi: 10.1007/s11684-013-0293-z

摘要：

The increased level of chromosome instability in cancer cells, leading to aneuploidy and gross chromosomal rearrangements, is not only a driving force for oncogenesis but also can be the Achille’s heel of the disease since many chemotherapies (CT) kill cells by inducing a non-tolerable rate of DNA damage. A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs. These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres. In agreement with this view, accelerated shortening of telomere length has been described in blood lineage cells following high-dose CT (stem cell transplantation) or non-myeloablative CT. However, almost nothing is known on the consequences of this shortening in terms of telomere stability, senescence and on the development of second cancers or post-treatment aging-like syndromes in cancer survivors (cognitive defect, fertility impairment, etc.). In this article, we propose: (1) telomeres of cancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance; (2) telomere functional parameters can be a surrogate marker of chemotherapy sensitivity and toxicity; (3) the use of anti-telomere molecule could greatly enhance the sensitivity to standards chemotherapies.

关键词： telomere     antineoplasic drugs     conventional chemotherapies    

HTML PDF 收藏
分享

Structural behavior of intermediate length cold-formed steel rack columns with C-stitches

M. ANBARASU, Mahmud ASHRAF

《结构与土木工程前沿（英文）》 2019年 第13卷 第4期   页码 937-949 doi: 10.1007/s11709-019-0528-4

摘要： This article presents an experimental and numerical investigation on the strength and performance of intermediate length rack column sections with C-stitches under axial compression. The test program consisted of 10 axial concentric compression tests on columns with and without C-stitches under pin end conditions for two different geometric lengths. Finite element (FE) models were developed using commercial FE package ABAQUS considering material and geometric nonlinearities as well as initial geometric imperfections. The elastic buckling properties of the section were calculated using readily available linear elastic buckling analysis tools based on Generalized Beam Theory (GBT) and Finite Strip Method (FSM). Obtained FE results were compared with those obtained experimentally, and once verified the developed FE modeling technique was used to carry out a parametric study to examine changes in structural response due to variations in length, depth and spacing of C-stitches. Observed influences of C-stitches on the behavior and resistance of the considered columns were carefully analyzed, and key design aspects are presented herein.

关键词： cold-formed steel columns     C-stitches     intermediate length columns     distortional buckling    

HTML PDF 收藏
分享

Secondary transfer length and residual prestress of fractured strand in post-tensioned concrete beams

《结构与土木工程前沿（英文）》   页码 388-400 doi: 10.1007/s11709-022-0809-1

摘要： An experimental study is performed on five post-tensioned concrete beams to explore the effects of different fracture positions on secondary transfer length and residual prestress of fractured strand. A numerical model is developed and used to predict the secondary transfer length and residual prestress of fractured strand in post-tensioned concrete beams. The model change interaction, which can deactivate and reactivate the elements for simulating the removal and reproduction of parts of the model, is used to reproduce the secondary anchorage of fractured strand. The numerical model is verified by experimental results. Results shows that the fractured strand can be re-anchored in concrete through the secondary anchorage, and the secondary transfer length of fractured strand with the diameter of 15.2 mm is 1133 mm. The residual prestress of fractured strand increases gradually in the secondary transfer length, and tends to be a constant beyond it. When the fractured strand is fully anchored in concrete, a minor prestress loss will appear, and the average prestress loss is 2.28% in the present study.

关键词： post-tensioned concrete beams     strand fracture     secondary transfer length     residual prestress    

HTML PDF 收藏
分享

Modelling of dynamic contact length in rail grinding process

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 242-248 doi: 10.1007/s11465-014-0305-y

摘要：

Rails endure frequent dynamic loads from the passing trains for supporting trains and guiding wheels. The accumulated stress concentrations will cause the plastic deformation of rail towards generating corrugations, contact fatigue cracks and also other defects, resulting in more dangerous status even the derailment risks. So the rail grinding technology has been invented with rotating grinding stones pressed on the rail with defects removal. Such rail grinding works are directed by experiences rather than scientifically guidance, lacking of flexible and scientific operating methods. With grinding control unit holding the grinding stones, the rail grinding process has the characteristics not only the surface grinding but also the running railway vehicles. First of all, it’s important to analyze the contact length between the grinding stone and the rail, because the contact length is a critical parameter to measure the grinding capabilities of stones. Moreover, it’s needed to build up models of railway vehicle unit bonded with the grinding stone to represent the rail grinding car. Therefore the theoretical model for contact length is developed based on the geometrical analysis. And the calculating models are improved considering the grinding car’s dynamic behaviors during the grinding process. Eventually, results are obtained based on the models by taking both the operation parameters and the structure parameters into the calculation, which are suitable for revealing the process of rail grinding by combining the grinding mechanism and the railway vehicle systems.

关键词： rail grinding     contact length     dynamic model     Hamiltonian system     grinding stone     rail grinding car    

HTML PDF 收藏
分享

The defect-length effect in corrosion detection with magnetic method for bridge cables

Qiwei ZHANG, Rongya XIN

《结构与土木工程前沿（英文）》 2018年 第12卷 第4期   页码 662-671 doi: 10.1007/s11709-018-0512-4

摘要：

Quantitative evaluation of the steel corrosion in cables is significant for the safe operation of cable-supported bridges. The magnetic flux (MF) examination shows great potential to detect the corrosion defect, or loss of metallic cross-sectional area (LMA). An LMA defect in steel cables can be measured accurately when it is longer than a certain length. However, for defects in early stage, where the length of corrosion area is short, the MF examination may produce unacceptable error. In this study, the effect of defect length on the MF examination for corrosion detection of bridge cables is investigated through theoretical analysis and model experiments. An original analytical model to quantify the influence of defect length is proposed based on the equivalent magnetic circuit method. Then, MF examination experiments are performed on a series of cable models with different defect lengths and locations to verify the analytical model. Further, parameter study is conducted based on the proposed analytical model to clarify the mechanism of the defect-length effect. The results show that the area loss caused by short corrosion damage will be underestimated if the defect-length effect is neglected, and this effect can be quantified efficiently with the proposed analytical model.

关键词： bridge cable     corrosion detection     defect length     MF examination     quantitative evaluation    

HTML PDF 收藏
分享

Optimization of aero-engine pipeline for avoiding vibration based on length adjustment of straight-line

《机械工程前沿（英文）》 2022年 第17卷 第1期   页码 11-11 doi: 10.1007/s11465-021-0667-x

摘要： In the design and troubleshooting of aero-engine pipeline, the vibration reduction of the pipeline system is often achieved by adjusting the hoop layout, provided that the shape of pipeline remains unchanged. However, in reality, the pipeline system with the best antivibration performance may be obtained only by adjusting the pipeline shape. In this paper, a typical spatial pipeline is taken as the research object, the length of straight-line segment is taken as the design variable, and an innovative optimization method of avoiding vibration of aero-engine pipeline is proposed. The relationship between straight-line segment length and parameters that determine the geometric characteristics of the pipeline, such as the position of key reference points, bending angle, and hoop position, are derived in detail. Based on this, the parametric finite element model of the pipeline system is established. Taking the maximum first-order natural frequency of pipeline as the optimization objective and introducing process constraints and vibration avoidance constraints, the optimization model of the pipeline system is established. The genetic algorithm and the golden section algorithm are selected to solve the optimization model, and the relevant solution procedure is described in detail. Finally, two kinds of pipelines with different total lengths are selected to carry out a case study. Based on the analysis of the influence of straight-line segment length on the vibration characteristics of the pipeline system, the optimization methods developed in this paper are demonstrated. Results show that the developed optimization method can obtain the optimal single value or interval of the straight-line segment length while avoiding the excitation frequency. In addition, the optimization efficiency of the golden section algorithm is remarkably higher than that of the genetic algorithm for length optimization of a single straight-line segment.

关键词： length adjustment     spatial pipeline     aero-engine     vibration avoidance optimization     genetic algorithm     golden section algorithm    

HTML PDF 收藏
分享

New form of geodetic coordinate system taking two length quantity as coordinate parameters

Yimin SHI, Ziyang ZHU, Yeming FAN

《结构与土木工程前沿（英文）》 2009年 第3卷 第1期   页码 105-110 doi: 10.1007/s11709-009-0014-5

摘要： A new form of geodetic coordinate system based on geodesic coordinates instead of geodetic longitude and latitude was proposed. The vertical and horizontal geodesic coordinates measured with length were defined as coordinate parameters, but the two families of coordinate curves were still meridians and parallel circles. The first fundamental form on the ellipsoidal surface and its three coefficients were deduced by the geodesic coordinate. The formula for the latitudinal scale factor of length for geodetic parallel lines was derived, by which the obtained result conformed to that standard value calculated from geodetic latitude, and it is applicable in the range of 400 km from north to south. Therefore, it lays the foundation for establishing the differential equation and differential relationship based on this type of coordinate parameters; and consequently, it is convenient and accurate enough to operate on the ellipsoidal surface in this new form of geodetic coordinate system.

关键词： geodetic coordinate system     meridian and parallel circle     coordinate parameter     the first fundamental form on the ellipsoidal surface     latitudinal scale factor of length    

HTML PDF 收藏
分享

Aerodynamic challenges in span length of suspension bridges

XIANG Haifan, GE Yaojun

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 153-162 doi: 10.1007/s11709-007-0016-0

摘要： The potential requirement of extreme bridge spans is firstly discussed according to horizontal clearances for navigation and economical construction of deep-water foundation. To ensure the technological feasibility of suspension bridges with longer spans, the static estimation of feasible span length is then made based on current material strength and weight of cables and deck. After the performances of the countermeasures for raising the aerodynamic stability are reviewed, a trial design of a 5 000 m suspension bridge, which is estimated as a reasonable limitation of span length, is finally conducted to respond to the tomorrow s challenge in span length of suspension bridges with the particular aspects, including dynamic stiffness, aerodynamic flutter and aerostatic stability.

关键词： requirement     reasonable limitation     challenge     particular     economical construction    

HTML PDF 收藏
分享

Synthesis of Intermittent-Motion Linkages with Slight Difference in Length Between Links

CHEN Xin-bo, YU Zhen

《机械工程前沿（英文）》 2006年 第1卷 第1期   页码 76-79 doi: 10.1007/s11465-005-0007-6

摘要：

The design of intermittent-motion linkages using traditional methods is usually complicated. In this paper, (1) a new method for realizing intermittent motion, using linkages with a slight difference in length between links, is studied; (2) some new types of intermittent-motion linkages and their software for visual analysis and design are developed; and (3) influences of some design parameters on intermittent-motion characteristics are clarified. Results confirmed that the theory and the software are useful, making the synthesis of intermittent-motion linkages clear and easy.

关键词： synthesis     useful     intermittent     intermittent-motion     traditional    

HTML PDF 收藏
分享

Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

《化学科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 456-463 doi: 10.1007/s11705-013-1357-y

摘要： Hydrophobic charge induction chromatography (HCIC) is a mixed-mode chromatography which is advantageous for high adsorption capacity and facile elution. The effect of the ligand chain length on protein behavior in HCIC was studied. A coarse-grain adsorbent pore model established in an earlier work was modified to construct adsorbents with different chain lengths, including one with shorter ligands (CL2) and one with longer ligands (CL4). The adsorption, desorption, and conformational transition of the proteins with CL2 and CL4 were examined using molecular dynamics simulations. The ligand chain length has a significant effect on both the probability and the irreversibility of the adsorption/desorption. Longer ligands reduced the energy barrier of adsorption, leading to stronger and more irreversible adsorption, as well as a little more unfolding of the protein. The simulation results elucidated the effect of the ligand chain length, which is beneficial for the rational design of adsorbents and parameter optimization for high-performance HCIC.

关键词： adsorption     desorption     irreversibility     protein conformational transition     molecular dynamics simulation    

HTML PDF 收藏
分享

Effect of nonionic side chain length of polycarboxylate-ether-based high-range water-reducing admixture

Süleyman ÖZEN, Muhammet Gökhan ALTUN, Ali MARDANI-AGHABAGLOU, Kambiz RAMYAR

《结构与土木工程前沿（英文）》 2020年 第14卷 第6期   页码 1573-1582 doi: 10.1007/s11709-020-0680-x

摘要： Despite the large variations in the behaviors of water-reducing admixtures upon changes in their structures, most previous reports on the cement-admixture compatibility did not provide sufficient information on the structure of the admixture. Hence, the evaluation and generalization of the reports on the cement-admixture compatibility are challenging. In this study, three different polycarboxylate-ether-based water-reducing admixtures with the same free nonionic content, anionic/nonionic molar ratio, and main chain length and different side chain lengths were produced. The compatibility of these admixtures with a CEM I 42.5R-type cement was investigated. In addition, an analysis of variance was performed on the experiment results to evaluate the contributions of the admixture type, admixture/cement ratio, and elapsing time to the Marsh funnel flow time, mini-slump, slump flow, and compressive strength. The water-reducing admixtures having long or short side chains reduced the initial flow characteristics of the cementitious systems. However, the admixture having the shortest side chain was better with regard to flow retention. The side chain length of the admixture did not have significant effects on the compressive strength and water absorption capacity of the mortar mixtures and mini-slump performances of the cement paste mixtures. Regarding the behaviors of the admixtures in the cementitious systems, an optimal admixture side chain molecular weight is proposed.

关键词： water-reducing admixture     side chain length     cement paste     fluidity     compressive strength    

HTML PDF 收藏
分享

Effect of embedment length of untreated natural fibres on the bond behaviour in cement mortar

Gudimella RAMAKRISHNA, Sriraman PRIYADHARSHINI

《结构与土木工程前沿（英文）》 2018年 第12卷 第4期   页码 454-460 doi: 10.1007/s11709-017-0454-2

摘要： The present investigation is focused on studying the effects of various matrices with 1:3, 1:4 and 1:5 mortars and fibre types of sisal and coir on the bond behavior at various ages of curing, i.e., 24 h, 3 d, 7 d and 28 d. The other parameters included in the investigation are water/cement (w/c) ratio, sand gradation and embedment length of fibres. In addition, the type of failure of sisal and coir fibres for different mixes of mortars at various curing ages is also reported. From the results, it is seen that the bond strength is improving with respect to age of curing in case of sisal fibres, but decreases in case of coir fibres. The failure of fibres due to fibre fracture is observed in sisal fibres and fibre pullout is observed in coir fibres. The other varying parameters such as mortar mixes, sand gradation, w/c ratio and embedded length also showed significant effect on bond behaviour of sisal and coir fibre with the cement mortar mixes.

关键词： bond strength     cement mortar     natural fibre     pullout test     type of failure    

HTML PDF 收藏
分享

标题 作者 时间 类型 操作

Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

null

期刊论文

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

null

期刊论文

Effects of slip length and hydraulic diameter on hydraulic entrance length of microchannels with superhydrophobic

Wenchi GONG, Jun SHEN, Wei DAI, Zeng DENG, Xueqiang DONG, Maoqiong GONG

期刊论文

Telomeric impact of conventional chemotherapy

null

期刊论文

Structural behavior of intermediate length cold-formed steel rack columns with C-stitches

M. ANBARASU, Mahmud ASHRAF

期刊论文

Secondary transfer length and residual prestress of fractured strand in post-tensioned concrete beams

期刊论文

Modelling of dynamic contact length in rail grinding process

null

期刊论文

The defect-length effect in corrosion detection with magnetic method for bridge cables

Qiwei ZHANG, Rongya XIN

期刊论文

Optimization of aero-engine pipeline for avoiding vibration based on length adjustment of straight-line

期刊论文

New form of geodetic coordinate system taking two length quantity as coordinate parameters

Yimin SHI, Ziyang ZHU, Yeming FAN

期刊论文

Aerodynamic challenges in span length of suspension bridges

XIANG Haifan, GE Yaojun

期刊论文

Synthesis of Intermittent-Motion Linkages with Slight Difference in Length Between Links

CHEN Xin-bo, YU Zhen

期刊论文

Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

期刊论文

Effect of nonionic side chain length of polycarboxylate-ether-based high-range water-reducing admixture

Süleyman ÖZEN, Muhammet Gökhan ALTUN, Ali MARDANI-AGHABAGLOU, Kambiz RAMYAR

期刊论文

Effect of embedment length of untreated natural fibres on the bond behaviour in cement mortar

Gudimella RAMAKRISHNA, Sriraman PRIYADHARSHINI

期刊论文