摘要: The dorsal part of the hippocampus is involved in spatial learning and memory processes, while the ventral is implicated in motivational and emotional behavior. These functions change during the night and day cycle, and they are altered in epilepsy. Here, we show that energy production (glycolysis versus oxidative phosphorylation) varies along the dorsoventral axis in a circadian manner ex vivo in control mice. These rules are altered in experimental epilepsy. Thus, energy production may be tailored to the function performed by hippocampal subdivisions and to the time of the day. Alterations in epilepsy may contribute to seizure generation and cognitive deficits. All study data are included in the article and/or [ SI Appendix ][1]. [1]: https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.2013972118/-/DCSupplemental