Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

Outline

Abstract
Keywords

Frontiers of Medicine

2007, Volume 1, Issue 4, Pages 398-400

PDF
collect

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

10.1007/s11684-007-0077-4

Cite this article

Abstract

The aim of this paper was to investigate the relationship between the expression of adrenomedullin (ADM) and microvessel density (MVD) and prognosis in smooth muscle tumor of uterus. The expression of ADM was detected using immunohistochemical staining in specimens from 15 normal controls, 28 cases of uterine leiomyoma (LE) and 19 cases of uterine leiomyosarcoma (LES). The MVD was assayed by immunostainting with CD. There was a positive correlation between the ADM expression and MVD in LE and LES respectively ( = 0.823, <0.01; = 0.793, <0.01). The expression of ADM in LE was statistically lower than that in LES (<0.05). There was a positive correlation between the ADM expression and mitotic figures in LES (<0.05): the more mitotic figures, the higher levels of the ADM expression and poor prognosis. The ADM is an important angiogenic factor in smooth muscle tumor of uterus. The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the pro gnosis of LES, and as a novel molecular target of anti-angiogenic and anticarcinogenic strategies.

Keywords

anticarcinogenic ; microvessel density ; malignant potency ; muscle ; uterine leiomyosarcoma

Previous article in issue

article in issue Next

Read

131

Download

Outline

Figures(5)

标签(1)

其他(2)

Frontiers of Medicine

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

Abstract

Keywords

评论

Outline

Figures(5)

标签(1)

其他(2)

Frontiers of Medicine

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

Abstract

Keywords

评论

Related Research