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2007, Volume 1, Issue 4

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Frontiers of Medicine >> 2007, Volume 1, Issue 4 doi: 10.1007/s11684-007-0083-6

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter baumannii

1.Nosocomial Infection Control Office of Ruijin Hospital, College of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China; 2.Department of Clinical Microbiology, Ruijin Hospital, College of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China; 3.Department of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310002, China;

Available online: 2007-12-05
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Abstract

This paper reported the epidemiology of the colistin-only-sensitive (COS-AB) in a tertiary teaching hospital in China. We analyzed the clinical data of 136 COS-AB isolates from June 2004 to May 2005 and collected 66 . isolates in which 33 strains were COS-AB, and the rest were non-COS-AB. Random amplified polymorphic DNA (RAPD) analysis (primer ERIC2 and 272) showed that all COS-AB were identical, while pulsed-field gel electrophotesis (PFGE) analysis showed two separate genotypes of these COS-AB which were distinctly different from that of non-COS-AB. The COS-AB from burn wards showed the identical PFGE pattern which was distinguished from the genotype of COS-AB in other departments, mainly surgical systems. The cross-infection was severe and strict methods of disinfection and sterilization should be implemented. Meanwhile, the epidemiology of COS-AB in environment and patients should be closely monitored. The PFGE analysis is a reliable method of . typing.

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