Frontiers of Medicine
>> 2008,
Volume 2,
Issue 2
doi:
10.1007/s11684-008-0038-6
Expression of heat shock protein gp96 in osteosarcoma
and its clinical significance
1.Department of Orthopaedics, Tongji Medical College, Huazhong University of Science & Technology；Department of Orthopaedics, Renmin Hospital of Wuhan University; 2.Department of Orthopaedics, Tongji Medical College, Huazhong University of Science & Technology;
Available online: 2008-06-05
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Abstract
This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and explore its role in anti-tumor immunity. Expression of HSPgp96 in 45 cases of osteosarcoma, including 24 cases of the osteoblast type, 21 cases of chondroblast type and 5 cases of normal bone tissue were detected by immunohistochemistry (IHC). The expression rate of HSPgp96 was 100% (45/45) in osteosarcoma, compared with 20% (1/5) in normal bone tissue. The average positive cell rates were 97.23% and 0.48% in osteosarcoma and normal bone tissue, respectively, and the difference between them was significant ( < 0.01). The positive cell rates in osteoblast type and chondroblast type were 97.78% and 96.56%, respectively, and the difference had no statistical significance ( > 0.05). The expression degree of HSPgp96 in osteosarcoma had a clear correlation with the pathologic degree ( < 0.05), while it had no relationship with the clinical stage ( > 0.05). The expression of HSPgp96 is high in osteosarcoma and it may be a significant index for judgment of malignancy degree and an important target site of anti-tumor immunity.
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