Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

2008, Volume 2, Issue 3

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Frontiers of Medicine >> 2008, Volume 2, Issue 3 doi: 10.1007/s11684-008-0060-8

Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

1.Department of Respiratory Diseases, Dongfang Hospital, Beijing University of Chinese Medicine; 2.Department of Internal Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine; 3.Department of Traditional Chinese Medicine, Beijing Royal Integrative Medicine Hospital; 4.Department of Pathology, Dongzhimen Hospital, Beijing University of Chinese Medicine

Available online: 2008-09-05

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Abstract

The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats. A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin. On days 14, 28 and 45, the contents of laminin, collagen I and collagen III in lung tissue homogenate in the model group, the sham operated group, the Feixian group and the prednisone group were measured. The contents of laminin and collagen I and III were decreased significantly by the Feixian Recipe. Feixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.

Keywords

bleomycin ; intratracheal injection ; prednisone ; collagen ; bleomycin-induced pulmonary

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