1.State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou 510060, China；Experimental Research Department, Sun Yat-sen University, Guangzhou, Guangdong 510060, China; 2.State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou 510060, China；Cancer Biotherapy Center, Sun Yat-sen University, Guangzhou 510060, China; 3.State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou 510060, China；Experimental Research Department, Sun Yat-sen University, Guangzhou, Guangdong 510060, China；Cancer Biotherapy Center, Sun Yat-sen University, Guangzhou 510060, China;