2011, Volume 5, Issue 1
Frontiers of Medicine >> 2011, Volume 5, Issue 1 doi: 10.1007/s11684-011-0119-9
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
Neurobiology Research Center, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, China
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Abstract
Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.
Keywords
protein kinase C ? ; signal transduction ; neurogenic disease
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