2012, Volume 6, Issue 1
Frontiers of Medicine >> 2012, Volume 6, Issue 1 doi: 10.1007/s11684-012-0171-0
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
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Abstract
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
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