Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

2012, Volume 6, Issue 3

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Frontiers of Medicine >> 2012, Volume 6, Issue 3 doi: 10.1007/s11684-012-0201-y

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Diabetes Center, 2nd Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha 410011, China

Available online: 2012-09-05

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Abstract

Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

Keywords

LADA ; diagnostic criteria ; autoantibodies ; insulin independence ; age of diagnosis

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