2012, Volume 6, Issue 3
Frontiers of Medicine >> 2012, Volume 6, Issue 3 doi: 10.1007/s11684-012-0216-4
Dual faces of SH2-containing protein-tyrosine phosphatase
1. Department of Pathology, and Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0864, USA;
2. Laboratory of Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, 225 Changhai Road, Shanghai 200438; State Key Laboratory of Oncogenes and Related Genes, Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China
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Abstract
PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.
Keywords
PTPN11/Shp2 ; leukemia ; hepatocellular carcinoma ; mutation
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