2014, Volume 8, Issue 1
Frontiers of Medicine >> 2014, Volume 8, Issue 1 doi: 10.1007/s11684-014-0317-3
Talin and kindlin: the one-two punch in integrin activation
Next Previous
Abstract
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.
Keywords
signal transduction ; transmembrane domain ; nanodisc ; integrin ; talin ; kindling ; cell adhesion
京公网安备 11010502051620号
