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Frontiers of Medicine >> 2014, Volume 8, Issue 2 doi: 10.1007/s11684-014-0319-1

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

1. Division of Hematology and Oncology, Department of Medicine, Westchester Medical Center, 100 Woods Rd, Valhalla, NY 10595, USA.

2. Department of Hematology, Xiamen Zhongshan Hospital, Xiamen University, Xiamen 361004, China.

3. Department of Pathology, Westchester Medical Center, 100 Woods Rd, Valhalla, NY 10595, USA.

4. Division of Cardiology, Department of Medicine, Westchester Medical Center, 100 Woods Rd, Valhalla, NY 10595, USA

Available online: 2014-05-21

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Abstract

Mantle cell lymphoma is an aggressive subtype of B cell non-Hodgkin lymphoma. It can progress to leukemic phase but frank leukemic picture at initial presentation is not common. Leukemic phase indicates advance stage of the disease and generally associated with extensive extra-nodal involvement. Pericardial invasion has been reported, however we could not find a report of myocardial infiltration by this disease since the appraisal of the term “mantle cell lymphoma” in 1992. Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which complicates the treatment decisions.

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