2016, Volume 10, Issue 1
Frontiers of Medicine >> 2016, Volume 10, Issue 1 doi: 10.1007/s11684-016-0433-3
Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
1. Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
2. Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
3. Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
4. Department of General Surgery, Nantong Tumor Hospital, Nantong 226361, China.
5. Department of Pathology, Nantong Tumor Hospital, Nantong 226361, China.
6. Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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Abstract
Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.
Keywords
PPM1D ; hepatocellular carcinoma ; prognosis ; target therapy
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