Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

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Frontiers of Medicine

2016, Volume 10, Issue 4, Pages 410-419

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Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

10.1007/s11684-016-0489-0

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Abstract

NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) in a myeloid/T lymphoid bi-phenoleukemia patient with t(3;11) and confirmed its leukemogenic ability. Herein, we demonstrated the association of NUP98-IQCG with CRM1, and found that NUP98-IQCG expression inhibits the CRM1-mediated nuclear export of p65 and enhances the transcriptional activity of nuclear factor-κB. Moreover, IQCG could be entrapped in the nucleus by NUP98-IQCG, and the fusion protein interacts with calmodulin via the IQ motif in a calcium-independent manner. Therefore, the inhibition of nuclear exports of p65 and IQCG might contribute to the leukemogenesis of NUP98-IQCG.

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NUP98-IQCG ; nuclear export ; NF-κB ; CRM1

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Frontiers of Medicine

Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Abstract

Keywords

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Outline

Figures(5)

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其他(2)

Frontiers of Medicine

Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Abstract

Keywords

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