2018, Volume 12, Issue 4
Frontiers of Medicine >> 2018, Volume 12, Issue 4 doi: 10.1007/s11684-018-0668-2
Regulation of T cell immunity by cellular metabolism
Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Next Previous
Abstract
T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.
Keywords
T cell immunity ; metabolic pathways ; nutrient uptake ; metabolic checkpoints
京公网安备 11010502051620号
